Inflammation in osteoarthritis: is it time to dampen the alarm(in) in this debilitating disease?

Running does not increase symptoms or structural progression in people with knee osteoarthritis: data from the osteoarthritis initiative

(2018) Grace H. Lo et al.   CLINICAL RHEUMATOLOGY

Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile inflammation

(2018) Thomas Vogl et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

(2018) Sujun Li et al.   MOLECULAR MEDICINE

A predominant Th1 polarization is present in synovial fluid of end-stage osteoarthritic knee joints - analysis of peripheral blood, synovial fluid & synovial membrane

(2018) Nils Rosshirt et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

S100-alarmins: potential therapeutic targets for arthritis

(2017) Judith Austermann et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Alarmins and immunity

(2017) De Yang et al.   IMMUNOLOGICAL REVIEWS

Unconventional Pathways of Secretion Contribute to Inflammation

(2017) Michael Daniels et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis

(2017) S.C.M. van Dalen et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

HMGB1, IL-1α, IL-33 and S100 proteins: dual-function alarmins

(2016) Damien Bertheloot et al.   Cellular & Molecular Immunology

Sensitization and Serological Biomarkers in Knee Osteoarthritis Patients With Different Degrees of Synovitis

(2016) Kristian K. Petersen et al.   CLINICAL JOURNAL OF PAIN

HMGB1: A critical mediator for oxidized-low density lipoproteins induced atherosclerosis

(2016) Qin Zhou et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Alarmin S100A9 Induces Proinflammatory and Catabolic Effects Predominantly in the M1 Macrophages of Human Osteoarthritic Synovium

(2016) M. H. van den Bosch et al.   JOURNAL OF RHEUMATOLOGY

P2X3 and P2X2/3 Receptors Play a Crucial Role in Articular Hyperalgesia Development Through Inflammatory Mechanisms in the Knee Joint Experimental Synovitis

(2016) Juliana Maia Teixeira et al.   MOLECULAR NEUROBIOLOGY

S100A8/A9: From basic science to clinical application

(2016) Monika Pruenster et al.   PHARMACOLOGY & THERAPEUTICS

Brief Report: Association of Inflammation With Development of Erosions in Patients With Hand Osteoarthritis: A Prospective Ultrasonography Study

(2016) Marion C. Kortekaas et al.   Arthritis & Rheumatology

Association of Joint Inflammation With Pain Sensitization in Knee Osteoarthritis: The Multicenter Osteoarthritis Study

(2016) Tuhina Neogi et al.   Arthritis & Rheumatology

Prophylactic treatment with S100A9 inhibitor paquinimod reduces pathology in experimental collagenase-induced osteoarthritis

(2015) R F Schelbergen et al.   ANNALS OF THE RHEUMATIC DISEASES

A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma

(2015) Aurora De Ponti et al.   CANCER LETTERS

Synovial Fluid HMGB-1 Levels are Associated with Osteoarthritis Severity

(2015) Xueru Ke et al.   Clinical Laboratory

The role of adipocytokines in the pathogenesis of knee joint osteoarthritis

(2015) Magdalena Richter et al.   INTERNATIONAL ORTHOPAEDICS

The Role of Innate Immunity in Osteoarthritis: When Our First Line of Defense Goes On the Offensive

(2015) E. W. Orlowsky et al.   JOURNAL OF RHEUMATOLOGY

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013

(2015) Theo Vos et al.   LANCET

Aging-related inflammation in osteoarthritis

(2015) M.A. Greene et al.   OSTEOARTHRITIS AND CARTILAGE

Fibronectin fragment-induced expression of matrix metalloproteinases is mediated by MyD88-dependent TLR-2 signaling pathway in human chondrocytes

(2015) Hyun Sook Hwang et al.   ARTHRITIS RESEARCH & THERAPY

Bioactivity in an Aggrecan 32-mer Fragment Is Mediated via Toll-like Receptor 2

(2015) Sophie Lees et al.   Arthritis & Rheumatology

Damage-Associated Molecular Patterns Generated in Osteoarthritis Directly Excite Murine Nociceptive Neurons Through Toll-like Receptor 4

(2015) Rachel E. Miller et al.   Arthritis & Rheumatology

Induction of Canonical Wnt Signaling by the Alarmins S100A8/A9 in Murine Knee Joints: Implications for Osteoarthritis

(2015) Martijn H. van den Bosch et al.   Arthritis & Rheumatology

Genomic Analysis and Differential Expression of HMG and S100A Family in Human Arthritis: Upregulated Expression of Chemokines, IL-8 and Nitric Oxide by HMGB1

(2014) Ashok R. Amin et al.   DNA AND CELL BIOLOGY

Blockade of Antimicrobial Proteins S100A8 and S100A9 Inhibits Phagocyte Migration to the Alveoli in Streptococcal Pneumonia

(2014) M.-A. Raquil et al.   JOURNAL OF IMMUNOLOGY

HMGB1 Develops Enhanced Proinflammatory Activity by Binding to Cytokines

(2014) Y. Sha et al.   JOURNAL OF IMMUNOLOGY

Proinflammatory S100 Proteins Regulate the Accumulation of Myeloid-Derived Suppressor Cells

(2014) P. Sinha et al.   JOURNAL OF IMMUNOLOGY

Heat Shock Protein 70, Released from Heat-Stressed Tumor Cells, Initiates Antitumor Immunity by Inducing Tumor Cell Chemokine Production and Activating Dendritic Cells via TLR4 Pathway

(2014) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

(2014) Selina K. Fassl et al.   JOURNAL OF IMMUNOLOGY

HMGB1–LPS complex promotes transformation of osteoarthritis synovial fibroblasts to a rheumatoid arthritis synovial fibroblast-like phenotype

(2014) Y Qin et al.   Cell Death & Disease

Alarmins MRP8 and MRP14 Induce Stress Tolerance in Phagocytes under Sterile Inflammatory Conditions

(2014) Judith Austermann et al.   Cell Reports

Hsp90 Inhibition Protects Against Biomechanically Induced Osteoarthritis in Rats

(2013) Michiel Siebelt et al.   ARTHRITIS AND RHEUMATISM

S100A12 levels in synovial fluid may reflect clinical severity in patients with primary knee osteoarthritis

(2013) Li-chun Wang et al.   BIOMARKERS

Effects of Intensive Diet and Exercise on Knee Joint Loads, Inflammation, and Clinical Outcomes Among Overweight and Obese Adults With Knee Osteoarthritis

(2013) Stephen P. Messier et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Identification of Osteoarthritis Biomarkers by Proteomic Analysis of Synovial Fluid

(2013) My Han et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation

(2013) Amy L. McNulty et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Effects of Running and Walking on Osteoarthritis and Hip Replacement Risk

(2013) PAUL T. WILLIAMS   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Biologic agents in osteoarthritis: hopes and disappointments

(2013) Xavier Chevalier et al.   Nature Reviews Rheumatology

Increased thymosin β4 levels in the serum and SF of knee osteoarthritis patients correlate with disease severity

(2013) Min Wei et al.   REGULATORY PEPTIDES

Robust shifts in S100a9 expression with aging: A novel mechanism for chronic inflammation

(2013) William R. Swindell et al.   Scientific Reports

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study

(2012) Leena Sharma et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Role of S100A12 in the pathogenesis of osteoarthritis

(2012) Motoshige Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

S100 proteins in cartilage: Role in arthritis

(2012) Raghunatha R. Yammani   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis

(2012) Beatrix Petersen et al.   EMBO JOURNAL

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Placebo-Controlled Trial of Oral Laquinimod for Multiple Sclerosis

(2012) Giancarlo Comi et al.   NEW ENGLAND JOURNAL OF MEDICINE

An Inflammation Loop Orchestrated by S100A9 and Calprotectin Is Critical for Development of Arthritis

(2012) Annabelle Cesaro et al.   PLoS One

Fecal HMGB1 Is a Novel Marker of Intestinal Mucosal Inflammation in Pediatric Inflammatory Bowel Disease

(2011) Roberta Vitali et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

HMGB1 and Microparticles as Mediators of the Immune Response to Cell Death

(2011) David S. Pisetsky et al.   ANTIOXIDANTS & REDOX SIGNALING

The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: A nested case-control study

(2011) Alex S. Nicholls et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Emergence of autoantibodies to HMGB1 is associated with survival in patients with septic shock

(2011) Stéphanie Barnay-Verdier et al.   INTENSIVE CARE MEDICINE

Identification of a Panel of Novel Serum Osteoarthritis Biomarkers

(2011) Patricia Fernández-Puente et al.   JOURNAL OF PROTEOME RESEARCH

Expression of β-defensin-4 in “an in vivo and ex vivo model” of human osteoarthritic knee meniscus

(2011) Giuseppe Musumeci et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

S100A8/A9 Activate Key Genes and Pathways in Colon Tumor Progression

(2011) M. Ichikawa et al.   MOLECULAR CANCER RESEARCH

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

(2011) Anna E. Denoble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin

(2010) P. Tewary et al.   BLOOD

Crystals, inflammation, and osteoarthritis

(2010) Ann K Rosenthal   CURRENT OPINION IN RHEUMATOLOGY

Correlation of changes in pain intensity with synovial fluid adenosine triphosphate levels after treatment of patients with osteoarthritis of the knee with high-molecular-weight hyaluronic acid

(2010) Nobuyuki Kumahashi et al.   KNEE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Prevalence of cam-type deformity on hip magnetic resonance imaging in young males: A cross-sectional study

(2010) Stephan Reichenbach et al.   ARTHRITIS CARE & RESEARCH

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes

(2010) Isabel García-Arnandis et al.   ARTHRITIS RESEARCH & THERAPY

Association between weight or body mass index and hand osteoarthritis: a systematic review

(2009) E. Yusuf et al.   ANNALS OF THE RHEUMATIC DISEASES

Interleukin-7 stimulates secretion of S100A4 by activating the JAK/STAT signaling pathway in human articular chondrocytes

(2009) Raghunatha R. Yammani et al.   ARTHRITIS AND RHEUMATISM

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis

(2009) Shaival H. Davé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO

(2009) Marieke A.D. van Zoelen et al.   SHOCK

Identification of Human S100A9 as a Novel Target for Treatment of Autoimmune Disease via Binding to Quinoline-3-Carboxamides

(2009) Per Björk et al.   PLOS BIOLOGY

Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis

(2008) Takashi Hamada et al.   ARTHRITIS AND RHEUMATISM

A neutralizing antibody against receptor for advanced glycation end products (RAGE) reduces atherosclerosis in uremic mice

(2008) Susanne Bro et al.   ATHEROSCLEROSIS

HMGB1: a two-headed signal regulating tumor progression and immunity

(2008) Lara Campana et al.   CURRENT OPINION IN IMMUNOLOGY

Phagocyte-specific S100 proteins are released from affected mucosa and promote immune responses during inflammatory bowel disease

(2008) D Foell et al.   JOURNAL OF PATHOLOGY

Is HMGB1 an osteocyte alarmin?

(2007) Joseph P. Bidwell et al.   JOURNAL OF CELLULAR BIOCHEMISTRY