Syndecans in cartilage breakdown and synovial inflammation

Early structural changes in cartilage and bone are required for the attachment and invasion of inflamed synovial tissue during destructive inflammatory arthritis

(2012) Adelheid Korb-Pap et al.   ANNALS OF THE RHEUMATIC DISEASES

Species-specific biological effects of FGF-2 in articular cartilage: Implication for distinct roles within the FGF receptor family

(2012) Xin Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

αvβ5 Integrin promotes dedifferentiation of monolayer-cultured articular chondrocytes

(2011) Naoshi Fukui et al.   ARTHRITIS AND RHEUMATISM

CXCL12γ isoform is expressed on endothelial and dendritic cells in rheumatoid arthritis synovium and regulates T cell activation

(2011) Begoña Santiago et al.   ARTHRITIS AND RHEUMATISM

The matrix metalloproteinase-7 regulates the extracellular shedding of syndecan-2 from colon cancer cells

(2011) Sojoong Choi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Syndecan-4 Hair Trigger Initiates Wound Healing through Caveolin- and RhoG-Regulated Integrin Endocytosis

(2011) Mark D. Bass et al.   DEVELOPMENTAL CELL

Rspo3 Binds Syndecan 4 and Induces Wnt/PCP Signaling via Clathrin-Mediated Endocytosis to Promote Morphogenesis

(2011) Bisei Ohkawara et al.   DEVELOPMENTAL CELL

IsN-sulfation just a gateway modification during heparan sulfate biosynthesis?

(2011) Karthik Raman et al.   FEBS LETTERS

TNF-α and IL-1β Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc

(2011) Jianru Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Two Distinct Sites in Sonic Hedgehog Combine for Heparan Sulfate Interactions and Cell Signaling Functions

(2011) Shu-Chun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP

(2011) Karoliina Vuoriluoto et al.   MATRIX BIOLOGY

Novel duplication in glypican-4 as an apparent cause of Simpson-Golabi-Behmel syndrome

(2010) John Waterson et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

Molecular Interactions of MMP-13 C-Terminal Domain with Chondrocyte Proteins

(2010) Liang Zhang et al.   CONNECTIVE TISSUE RESEARCH

Inhibition of pulmonary fibrosis in mice by CXCL10 requires glycosaminoglycan binding and syndecan-4

(2010) Dianhua Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

A novel homozygous MMP2 mutation in a patient with Torg–Winchester syndrome

(2010) Seon-Yong Jeong et al.   JOURNAL OF HUMAN GENETICS

Fibronectin fragment activation of ERK increasing integrin α5 and β1 subunit expression to degenerate nucleus pulposus cells

(2010) Maosheng Xia et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Cartilage ultrastructure in proteoglycan-deficient zebrafish mutants brings to light new candidate genes for human skeletal disorders

(2010) Malgorzata I Wiweger et al.   JOURNAL OF PATHOLOGY

Syndecans as cell surface receptors: Unique structure equates with functional diversity

(2010) Youngsil Choi et al.   MATRIX BIOLOGY

Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells

(2010) M. Endres et al.   OSTEOARTHRITIS AND CARTILAGE

Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways

(2010) S. Otsuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syndecan-2 and Decorin: Proteoglycans With a Difference—Implications in Keloid Pathogenesis

(2010) Anandaroop Mukhopadhyay et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Glycosaminoglycans and syndecan-4 are involved in SDF-1/CXCL12-mediated invasion of human epitheloid carcinoma HeLa cells

(2009) Severine Brule et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Differential roles for membrane-bound and soluble syndecan-1 (CD138) in breast cancer progression

(2009) Viktoriya Nikolova et al.   CARCINOGENESIS

A role for Syndecan-4 in neural induction involving ERK- and PKC-dependent pathways

(2009) S. Kuriyama et al.   DEVELOPMENT

Extra-embryonic syndecan 2 regulates organ primordia migration and fibrillogenesis throughout the zebrafish embryo

(2009) C. B. Arrington et al.   DEVELOPMENT

Craniofacial skeletal defects of adult zebrafishGlypican 4 (knypek)mutants

(2009) Elizabeth E. LeClair et al.   DEVELOPMENTAL DYNAMICS

Syndecan-2 Functions as a Docking Receptor for Pro-matrix Metalloproteinase-7 in Human Colon Cancer Cells

(2009) Heui-Young Ryu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Heparan Sulfate Proteoglycan Modulation of Wnt5A Signal Transduction in Metastatic Melanoma Cells

(2009) Michael P. O'Connell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Disintegrin and Metalloproteinase 17 (ADAM17) Mediates Inflammation-induced Shedding of Syndecan-1 and -4 by Lung Epithelial Cells

(2009) Jessica Pruessmeyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 regulates αvβ3and αvβ5integrin activation during angiogenesis and is blocked by synstatin, a novel peptide inhibitor

(2009) DeannaLee M. Beauvais et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Membrane Type 1 Matrix Metalloproteinase-Mediated Stromal Syndecan-1 Shedding Stimulates Breast Carcinoma Cell Proliferation

(2008) G. Su et al.   CANCER RESEARCH

Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion

(2008) Juan Carlos Rodríguez-Manzaneque et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Postsynaptic Density 95/Disc-Large/Zona Occludens Protein Syntenin Directly Interacts with Frizzled 7 and Supports Noncanonical Wnt Signaling

(2008) Annouck Luyten et al.   MOLECULAR BIOLOGY OF THE CELL

Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage

(2008) Shuhei Otsuki et al.   ARTHRITIS RESEARCH & THERAPY