Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

(2012) Anjali Nair et al.   ARTHRITIS AND RHEUMATISM

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Osteoarthritis-associated basic calcium phosphate crystals induce pro-inflammatory cytokines and damage-associated molecules via activation of Syk and PI3 kinase

(2012) Clare C. Cunningham et al.   CLINICAL IMMUNOLOGY

Induction of the chemokine IL-8/Kc by the articular cartilage: Possible influence on osteoarthritis

(2012) Karine Chauffier et al.   JOINT BONE SPINE

2012 Update of the 2008 American College of Rheumatology recommendations for the use of disease-modifying antirheumatic drugs and biologic agents in the treatment of rheumatoid arthritis

(2012) Jasvinder A. Singh et al.   ARTHRITIS CARE & RESEARCH

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Oral Inflammatory Diseases and Systemic Inflammation: Role of the Macrophage

(2012) Hatice Hasturk et al.   Frontiers in Immunology

Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study

(2011) F. W. Roemer et al.   ANNALS OF THE RHEUMATIC DISEASES

Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases

(2011) Wang Hui et al.   ANNALS OF THE RHEUMATIC DISEASES

Correlation of Plasma and Synovial Fluid Adiponectin with Knee Osteoarthritis Severity

(2011) Sittisak Honsawek et al.   ARCHIVES OF MEDICAL RESEARCH

Quantitative magnetic resonance imaging evidence of synovial proliferation is associated with radiographic severity of knee osteoarthritis

(2011) Svetlana Krasnokutsky et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Serum resistin level is associated with radiographic changes in hand osteoarthritis: Cross-sectional study

(2011) Jung-Yoon Choe et al.   JOINT BONE SPINE

Basic Calcium Phosphate Crystals Induce Monocyte/Macrophage IL-1  Secretion through the NLRP3 Inflammasome In Vitro

(2011) B. Pazar et al.   JOURNAL OF IMMUNOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis

(2011) C. Pauli et al.   OSTEOARTHRITIS AND CARTILAGE

Comparing non-enhanced and enhanced sequences in the assessment of effusion and synovitis in knee OA: associations with clinical, macroscopic and microscopic features

(2011) D. Loeuille et al.   OSTEOARTHRITIS AND CARTILAGE

Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation

(2011) Anna E. Denoble et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Age-Related Macular Degeneration (AMD)

(2011) David G. Telander   Seminars in Ophthalmology

Expression of Toll-like receptors 2 and 4 in stifle joint synovial tissues of dogs with or without osteoarthritis

(2010) Keiichi Kuroki et al.   AMERICAN JOURNAL OF VETERINARY RESEARCH

Current evidence for a strategic approach to the management of rheumatoid arthritis with disease-modifying antirheumatic drugs: a systematic literature review informing the EULAR recommendations for the management of rheumatoid arthritis

(2010) R. Knevel et al.   ANNALS OF THE RHEUMATIC DISEASES

Synovial tissue-infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation

(2010) Ryan S. Huss et al.   ARTHRITIS AND RHEUMATISM

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

The role of synovial macrophages and macrophage-produced mediators in driving inflammatory and destructive responses in osteoarthritis

(2010) Jan Bondeson et al.   ARTHRITIS AND RHEUMATISM

Synovial inflammation in patients undergoing arthroscopic meniscectomy: Molecular characterization and relationship to symptoms

(2010) Carla R. Scanzello et al.   ARTHRITIS AND RHEUMATISM

Increased serum concentrations of visfatin and its production by different joint tissues in patients with osteoarthritis

(2010) Wei-ping Chen et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Crystals, inflammation, and osteoarthritis

(2010) Ann K Rosenthal   CURRENT OPINION IN RHEUMATOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Clinical and ultrasonographic predictors of joint replacement for knee osteoarthritis: results from a large, 3-year, prospective EULAR study

(2009) P. G. Conaghan et al.   ANNALS OF THE RHEUMATIC DISEASES

Comparison of tocilizumab monotherapy versus methotrexate monotherapy in patients with moderate to severe rheumatoid arthritis: the AMBITION study

(2009) G. Jones et al.   ANNALS OF THE RHEUMATIC DISEASES

Increased serum adiponectin levels in female patients with erosive compared with non-erosive osteoarthritis

(2009) M Filkova et al.   ANNALS OF THE RHEUMATIC DISEASES

Correlation of synovial fluid leptin concentrations with the severity of osteoarthritis

(2009) Jung Hoei Ku et al.   CLINICAL RHEUMATOLOGY

Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors

(2009) Andrea Babelova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage-derived human resistin exacerbates adipose tissue inflammation and insulin resistance in mice

(2009) Mohammed Qatanani et al.   JOURNAL OF CLINICAL INVESTIGATION

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease

(2009) C.R. Scanzello et al.   OSTEOARTHRITIS AND CARTILAGE

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized

(2009) David J Hunter et al.   ARTHRITIS RESEARCH & THERAPY

Premorbid knee osteoarthritis is not characterised by diffuse thinness: the Framingham Osteoarthritis Study

(2008) D J Hunter et al.   ANNALS OF THE RHEUMATIC DISEASES

Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI

(2008) J-P Raynauld et al.   ANNALS OF THE RHEUMATIC DISEASES

Crystals of monosodium urate monohydrate enhance lipopolysaccharide-induced release of interleukin 1  by mononuclear cells through a caspase 1-mediated process

(2008) E J Giamarellos-Bourboulis et al.   ANNALS OF THE RHEUMATIC DISEASES

Crucial role of visfatin/pre–B cell colony-enhancing factor in matrix degradation and prostaglandin E2 synthesis in chondrocytes: Possible influence on osteoarthritis

(2008) Marjolaine Gosset et al.   ARTHRITIS AND RHEUMATISM

Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound?

(2008) Carla R Scanzello et al.   CURRENT OPINION IN RHEUMATOLOGY

Short leucine-rich glycoproteins of the extracellular matrix display diverse patterns of complement interaction and activation

(2008) Andreas P. Sjöberg et al.   MOLECULAR IMMUNOLOGY

Incidental Meniscal Findings on Knee MRI in Middle-Aged and Elderly Persons

(2008) Martin Englund et al.   NEW ENGLAND JOURNAL OF MEDICINE

A new non-invasive method to assess synovitis severity in relation to symptoms and cartilage volume loss in knee osteoarthritis patients using MRI

(2008) J.-P. Pelletier et al.   OSTEOARTHRITIS AND CARTILAGE

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

(2008) James Melrose et al.   ARTHRITIS RESEARCH & THERAPY

Are there promising biologic therapies for osteoarthritis?

(2008) David J. Hunter   Current Rheumatology Reports

Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging

(2007) I H Song et al.   ANNALS OF THE RHEUMATIC DISEASES