Nutraceuticals: Potential for Chondroprotection and Molecular Targeting of Osteoarthritis

The clinical effectiveness of glucosamine and chondroitin supplements in slowing or arresting progression of osteoarthritis of the knee: a systematic review and economic evaluation

(2014) C Black et al.   HEALTH TECHNOLOGY ASSESSMENT

Edible Bird’s nest extract as a chondro-protective agent for human chondrocytes isolated from osteoarthritic knee: in vitro study

(2013) Kien-Hui Chua et al.   BMC Complementary and Alternative Medicine

Does Vitamin D Improve Osteoarthritis of the Knee: A Randomized Controlled Pilot Trial

(2013) Divya Sanghi et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Effect of Vitamin D Supplementation on Progression of Knee Pain and Cartilage Volume Loss in Patients With Symptomatic Osteoarthritis

(2013) Timothy McAlindon et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Willow bark extract STW 33-I in the long-term treatment of outpatients with rheumatic pain mainly osteoarthritis or back pain

(2013) B. Uehleke et al.   PHYTOMEDICINE

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Aging processes and the development of osteoarthritis

(2012) Richard F. Loeser   CURRENT OPINION IN RHEUMATOLOGY

Dietary polyphenols and mechanisms of osteoarthritis

(2012) Chwan-Li Shen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice

(2012) Francisca Helvira Cavalcante Melo et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Age-related OA—a concept emerging from infancy?

(2012) Thomas Aigner et al.   Nature Reviews Rheumatology

Metabolic syndrome meets osteoarthritis

(2012) Qi Zhuo et al.   Nature Reviews Rheumatology

Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review

(2012) J.P.J. Van Vijven et al.   OSTEOARTHRITIS AND CARTILAGE

Rebamipide attenuates pain severity and cartilage degeneration in a rat model of osteoarthritis by downregulating oxidative damage and catabolic activity in chondrocytes

(2012) S.-J. Moon et al.   OSTEOARTHRITIS AND CARTILAGE

Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study

(2012) K.R. Baker et al.   OSTEOARTHRITIS AND CARTILAGE

Epidemiology of Osteoarthritis and Associated Comorbidities

(2012) Pradeep Suri et al.   PM&R

Pharmaceutical Therapy for Osteoarthritis

(2012) David S. Cheng et al.   PM&R

Intersection of Inflammation and Herbal Medicine in the Treatment of Osteoarthritis

(2012) Ali Mobasheri   Current Rheumatology Reports

Green-lipped mussel (Perna canaliculus) extract efficacy in knee osteoarthritis and improvement in gastrointestinal dysfunction: a pilot study

(2012) Samantha Coulson et al.   INFLAMMOPHARMACOLOGY

Current nutraceuticals in the management of osteoarthritis: a review

(2012) Nahid Akhtar et al.   Therapeutic Advances in Musculoskeletal Disease

Levels of reactive oxygen metabolites in patients with knee osteoarthritis

(2011) Kazuhiko Kotani et al.   AUSTRALASIAN JOURNAL ON AGEING

Calcium Fructoborate—Potential Anti-inflammatory Agent

(2011) Romulus Ion Scorei et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis

(2011) Yun Ju Woo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Caesalpinia sappan extract inhibits IL1β-mediated overexpression of matrix metalloproteinases in human chondrocytes

(2011) Stefan Toegel et al.   Genes and Nutrition

Curcumin Modulates Nuclear Factor κB (NF-κB)-mediated Inflammation in Human Tenocytesin Vitro

(2011) Constanze Buhrmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages

(2011) Shengqian Q. Wu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract

(2011) Krishanu Sengupta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Carvacrol attenuates mechanical hypernociception and inflammatory response

(2011) Adriana G. Guimarães et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Regulation of osteoarthritis by omega-3 (n-3) polyunsaturated fatty acids in a naturally occurring model of disease

(2011) L. Knott et al.   OSTEOARTHRITIS AND CARTILAGE

Molecular Targets of the Antiinflammatory Harpagophytum procumbens (Devil's claw): Inhibition of TNFα and COX-2 Gene Expression by Preventing Activation of AP-1

(2011) Bernd L. Fiebich et al.   PHYTOTHERAPY RESEARCH

Managing the adverse effects of nonsteroidal anti-inflammatory drugs

(2011) Paola Patrignani et al.   Expert Review of Clinical Pharmacology

Mechanical loading, cartilage degradation, and arthritis

(2010) Hui B. Sun   Annals of the New York Academy of Sciences

Clinical efficacy and safety of glucosamine, chondroitin sulphate, their combination, celecoxib or placebo taken to treat osteoarthritis of the knee: 2-year results from GAIT

(2010) A. D. Sawitzke et al.   ANNALS OF THE RHEUMATIC DISEASES

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Bioassay-guided Evaluation of Antioxidant and Antinociceptive Activities of Carvacrol

(2010) Adriana G. Guimarães et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Phase 1, placebo-controlled, dose escalation trial of chicory root extract in patients with osteoarthritis of the hip or knee

(2010) Nancy J Olsen et al.   BMC MUSCULOSKELETAL DISORDERS

Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: An 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients

(2010) Jinhyun Kim et al.   CLINICAL THERAPEUTICS

Disease Modifying Osteoarthritis Drugs: Facing Development Challenges and Choosing Molecular Targets

(2010) Marie-Pierre Hellio Le Graverand-Gastineau   CURRENT DRUG TARGETS

Oxidant conditioning protects cartilage from mechanically induced damage

(2010) Prem Ramakrishnan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Lactobacillus casei enhances type II collagen/glucosamine-mediated suppression of inflammatory responses in experimental osteoarthritis

(2010) Jae-Seon So et al.   LIFE SCIENCES

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Getting arthritis gene therapy into the clinic

(2010) Christopher H. Evans et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Nutraceuticals: do they represent a new era in the management of osteoarthritis? – a narrative review from the lessons taken with five products

(2010) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Safety and toxicological evaluation of Aflapin®: A novel Boswellia-derived anti-inflammatory product

(2010) A. V. Krishnaraju et al.   TOXICOLOGY MECHANISMS AND METHODS

Pomegranate extract inhibits the interleukin-1β-induced activation of MKK-3, p38α-MAPK and transcription factor RUNX-2 in human osteoarthritis chondrocytes

(2010) Zafar Rasheed et al.   ARTHRITIS RESEARCH & THERAPY

Interleukin-1β-Induced Extracellular Matrix Degradation and Glycosaminoglycan Release Is Inhibited by Curcumin in an Explant Model of Cartilage Inflammation

(2009) Abigail L. Clutterbuck et al.   Annals of the New York Academy of Sciences

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Intraarticular injection of anakinra in osteoarthritis of the knee: A multicenter, randomized, double-blind, placebo-controlled study

(2009) X. Chevalier et al.   ARTHRITIS AND RHEUMATISM

Insurer and out-of-pocket costs of osteoarthritis in the US: Evidence from national survey data

(2009) Harry Kotlarz et al.   ARTHRITIS AND RHEUMATISM

Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes

(2009) M. Mathy-Hartert et al.   INFLAMMATION RESEARCH

OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?

(2009) M.-P. Hellio Le Graverand-Gastineau   OSTEOARTHRITIS AND CARTILAGE

Biological actions of curcumin on articular chondrocytes

(2009) Y. Henrotin et al.   OSTEOARTHRITIS AND CARTILAGE

Green tea extract inhibits chemokine production, but up-regulates chemokine receptor expression, in rheumatoid arthritis synovial fibroblasts and rat adjuvant-induced arthritis

(2009) H. Marotte et al.   RHEUMATOLOGY

Treatment of erosive osteoarthritis of the hands by intra-articular infliximab injections: a pilot study

(2009) Antonella Fioravanti et al.   RHEUMATOLOGY INTERNATIONAL

Protective effects of total fraction of avocado/soybean unsaponifiables on the structural changes in experimental dog osteoarthritis: inhibition of nitric oxide synthase and matrix metalloproteinase-13

(2009) Christelle Boileau et al.   ARTHRITIS RESEARCH & THERAPY

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

(2009) Constanze Csaki et al.   ARTHRITIS RESEARCH & THERAPY

The effect of glucosamine and/or chondroitin sulfate on the progression of knee osteoarthritis: A report from the glucosamine/chondroitin arthritis intervention trial

(2008) Allen D. Sawitzke et al.   ARTHRITIS AND RHEUMATISM

Resveratrol suppresses interleukin-1β-induced inflammatory signaling and apoptosis in human articular chondrocytes: Potential for use as a novel nutraceutical for the treatment of osteoarthritis

(2008) Mehdi Shakibaei et al.   BIOCHEMICAL PHARMACOLOGY

Oral Administration of Highly Oligomeric Procyanidins of Jatoba Reduces the Severity of Collagen-Induced Arthritis

(2008) Mika MIYAKE et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast

(2008) Qingying Meng et al.   FREE RADICAL BIOLOGY AND MEDICINE

6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages

(2008) Min-Hsiung Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients? – a meta-analysis of randomized controlled trials

(2008) R. Christensen et al.   OSTEOARTHRITIS AND CARTILAGE

Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury

(2008) E.A. Regan et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of cyclooxygenase 2 expression by diallyl sulfide on joint inflammation induced by urate crystal and IL-1β

(2008) H.-S. Lee et al.   OSTEOARTHRITIS AND CARTILAGE

Epigallocatechin-3-gallate suppresses TNF-α -induced production of MMP-1 and -3 in rheumatoid arthritis synovial fibroblasts

(2008) Hee-Jin Yun et al.   RHEUMATOLOGY INTERNATIONAL

Nitric oxide in inflammation and pain associated with osteoarthritis

(2008) Steven B Abramson   ARTHRITIS RESEARCH & THERAPY

Regulation of inflammation signalling by resveratrol in human chondrocytes in vitro

(2007) Constanze Csaki et al.   BIOCHEMICAL PHARMACOLOGY

Chondroprotective Potential of Fruit Extracts ofPhyllanthus emblicain Osteoarthritis

(2007) Venil N. Sumantran et al.   Evidence-based Complementary and Alternative Medicine

Molecular network of cartilage homeostasis and osteoarthritis

(2007) Megumi Hashimoto et al.   MEDICINAL RESEARCH REVIEWS

Symptomatic efficacy of avocado–soybean unsaponifiables (ASU) in osteoarthritis (OA) patients: a meta-analysis of randomized controlled trials

(2007) R. Christensen et al.   OSTEOARTHRITIS AND CARTILAGE