Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
Volume 1822, Issue 4, Pages 600-606Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbadis.2012.01.006
Keywords
S100 protein; Cartilage; Chondrocyte; Arthritis; Osteoarthritis (OA)
Funding
- National Institutes of Health (NIH) [R03 AR061050]
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S100 proteins are low molecular weight calcium binding proteins expressed in vertebrates. The family constitutes 21 known members that are expressed in several tissues and cell types and play a major role in various cellular functions. Uniquely, members of the S100 family have both intracellular and extracellular functions. Several members of the S100 family (S100A1, S100A2, S100A4, S1008, S100A9, S100A11, and S100B) have been identified in human articular cartilage, and their expression is upregulated in diseased tissue. These 5100 proteins elicit a catabolic signaling pathway via receptor for advanced glycation end products (RAGE) in cartilage and may promote progression of arthritis. This review summarizes our current understanding of the role of S100 proteins in cartilage biology and in the development of arthritis. (C) 2012 Elsevier B.V. All rights reserved.
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