Trabecular bone organoids: a micron-scale ‘humanised’ prototype designed to study the effects of microgravity and degeneration

An Organoid for Woven Bone

(2021) Anat Akiva et al.   ADVANCED FUNCTIONAL MATERIALS

Gravity sensing in plant and animal cells

(2021) Ken Takahashi et al.   NPJ Microgravity

A Comparison of Osteoblast and Osteoclast In Vitro Co-Culture Models and Their Translation for Preclinical Drug Testing Applications

(2020) Alexander Sieberath et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Chemically Defined Hydrogel for Human Liver Organoid Culture

(2020) Shicheng Ye et al.   ADVANCED FUNCTIONAL MATERIALS

Hair-bearing human skin generated entirely from pluripotent stem cells

(2020) Jiyoon Lee et al.   NATURE

Sclerostin expression in trabecular bone is downregulated by osteoclasts

(2020) Masanori Koide et al.   Scientific Reports

Injectable pre-cultured tissue modules catalyze the formation of extensive functional microvasculature in vivo

(2020) Nicole E. Friend et al.   Scientific Reports

Disease modelling in human organoids

(2019) Madeline A. Lancaster et al.   Disease Models & Mechanisms

Mediation of the Acute Stress Response by the Skeleton

(2019) Julian Meyer Berger et al.   Cell Metabolism

Developmentally Engineered Callus Organoid Bioassemblies Exhibit Predictive In Vivo Long Bone Healing

(2019) Gabriella Nilsson Hall et al.   Advanced Science

A novel method for the collection of nanoscopic vesicles from an organotypic culture model

(2018) Alexandra Iordachescu et al.   RSC Advances

Journey into Bone Models: A Review

(2018) Julia Scheinpflug et al.   Genes

Adiponectin Reduces Bone Stiffness: Verified in a Three-Dimensional Artificial Human Bone Model In Vitro

(2018) Sigrid Haugen et al.   Frontiers in Endocrinology

From the Clinical Problem to the Basic Research—Co-Culture Models of Osteoblasts and Osteoclasts

(2018) Sheng Zhu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids

(2018) Huili Hu et al.   CELL

Human Intestinal Organoids Maintain Self-Renewal Capacity and Cellular Diversity in Niche-Inspired Culture Condition

(2018) Masayuki Fujii et al.   Cell Stem Cell

Osteoblast-derived Laminin-332 is a novel negative regulator of osteoclastogenesis in bone microenvironments

(2017) Norihisa Uehara et al.   LABORATORY INVESTIGATION

Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium

(2017) Margherita Y. Turco et al.   NATURE CELL BIOLOGY

How to prevent the detrimental effects of two months of bed-rest on muscle, bone and cardiovascular system: an RCT

(2017) Andreas Kramer et al.   Scientific Reports

Optimising reliability of mouse performance in behavioural testing: the major role of non-aversive handling

(2017) Kelly Gouveia et al.   Scientific Reports

Irisin prevents and restores bone loss and muscle atrophy in hind-limb suspended mice

(2017) Graziana Colaianni et al.   Scientific Reports

Calcium and vitamin-D deficiency marginally impairs fracture healing but aggravates posttraumatic bone loss in osteoporotic mice

(2017) Verena Fischer et al.   Scientific Reports

Establishment of a 3D-dynamic osteoblasts–osteoclasts co-culture model to simulate the jawbone microenvironment in vitro

(2016) Letizia Penolazzi et al.   LIFE SCIENCES

Disrupted Bone Metabolism in Long-Term Bedridden Patients

(2016) Keiko Eimori et al.   PLoS One

Alterations of the cytoskeleton in human cells in space proved by life-cell imaging

(2016) Thomas J. Corydon et al.   Scientific Reports

The 3D structure of the collagen fibril network in human trabecular bone: Relation to trabecular organization

(2015) Natalie Reznikov et al.   BONE

Parathyroid hormone: anabolic and catabolic actions on the skeleton

(2015) Barbara C Silva et al.   CURRENT OPINION IN PHARMACOLOGY

A mesoscale study of the degradation of bone structural properties in modeled microgravity conditions

(2015) Francesca Cosmi et al.   Journal of the Mechanical Behavior of Biomedical Materials

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2015) Minoru Takasato et al.   NATURE

Impact of hip fracture on hospital care costs: a population-based study

(2015) J. Leal et al.   OSTEOPOROSIS INTERNATIONAL

Attenuation of hind-limb suspension-induced bone loss by curcumin is associated with reduced oxidative stress and increased vitamin D receptor expression

(2015) M. Xin et al.   OSTEOPOROSIS INTERNATIONAL

Ovariectomy shortens the life span of female mice

(2015) Valeria Benedusi et al.   Oncotarget

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Gradual adaptation of bone structure to aquatic lifestyle in extinct sloths from Peru

(2014) E. Amson et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization

(2013) Kuniaki Ota et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Microtubule Dynamic Instability Controls Podosome Patterning in Osteoclasts through EB1, Cortactin, and Src

(2013) M. Biosse Duplan et al.   MOLECULAR AND CELLULAR BIOLOGY

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Microgravity Induces Pelvic Bone Loss through Osteoclastic Activity, Osteocytic Osteolysis, and Osteoblastic Cell Cycle Inhibition by CDKN1a/p21

(2013) Elizabeth A. Blaber et al.   PLoS One

Osteoporosis in the European Union: medical management, epidemiology and economic burden

(2013) E. Hernlund et al.   Archives of Osteoporosis

Effects of PTH on osteocyte function

(2012) Teresita Bellido et al.   BONE

The Insulin-Like Growth Factor System in Bone

(2012) Masanobu Kawai et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Fracture healing under healthy and inflammatory conditions

(2012) Lutz Claes et al.   Nature Reviews Rheumatology

Mechanical stress-activated integrin  5 1 induces opening of connexin 43 hemichannels

(2012) N. Batra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Sclerostin Stimulates Osteocyte Support of Osteoclast Activity by a RANKL-Dependent Pathway

(2011) Asiri R. Wijenayaka et al.   PLoS One

A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

(2011) Ramsey Foty   Jove-Journal of Visualized Experiments

Aging and bone loss: new insights for the clinician

(2011) Oddom Demontiero et al.   Therapeutic Advances in Musculoskeletal Disease

The use of fibrin glue in surgery of the knee

(2010) S. Patel et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

Indomethacin inhibition of tenotomy-induced bone resorption in rats

(2010) D.D. Thompson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Growth factors to stimulate bone formation

(2010) David J. Baylink et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Ovariectomy, a model of menopause in rodents, causes a premature aging of the nervous and immune systems

(2010) I. Baeza et al.   JOURNAL OF NEUROIMMUNOLOGY

Bone density and the lightweight skeletons of birds

(2010) E. R. Dumont   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Microgravity during spaceflight directly affects in vitro osteoclastogenesis and bone resorption

(2009) Roberto Tamma et al.   FASEB JOURNAL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Transcriptional Analysis of Fracture Healing and the Induction of Embryonic Stem Cell–Related Genes

(2009) Manish Bais et al.   PLoS One

Osteocytes, mechanosensing and Wnt signaling

(2008) Lynda F. Bonewald et al.   BONE

The Effects of Twelve Weeks of Bed Rest on Bone Histology, Biochemical Markers of Bone Turnover, and Calcium Homeostasis in Eleven Normal Subjects

(2006) Joseph E. Zerwekh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone-Resorbing Osteoclasts Contain Gap-Junctional Connexin-43

(2006) Joanna Ilvesaro et al.   JOURNAL OF BONE AND MINERAL RESEARCH