On-chip 3D neuromuscular model for drug screening and precision medicine in neuromuscular disease

A 3D culture model of innervated human skeletal muscle enables studies of the adult neuromuscular junction

(2019) Mohsen Afshar Bakooshli et al.   eLife

Mouse models of ALS: Past, present and future

(2018) Cathleen Lutz   BRAIN RESEARCH

Three-Dimensional Human iPSC-Derived Artificial Skeletal Muscles Model Muscular Dystrophies and Enable Multilineage Tissue Engineering

(2018) Sara Martina Maffioletti et al.   Cell Reports

Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent

(2018) Koki Fujimori et al.   NATURE MEDICINE

The relationship between four GWAS-identified loci in Alzheimer’s disease and the risk of Parkinson's disease, amyotrophic lateral sclerosis, and multiple system atrophy

(2018) Yongping Chen et al.   NEUROSCIENCE LETTERS

Harnessing cellular aging in human stem cell models of amyotrophic lateral sclerosis

(2018) Oliver J. Ziff et al.   AGING CELL

Microphysiological 3D model of amyotrophic lateral sclerosis (ALS) from human iPS-derived muscle cells and optogenetic motor neurons

(2018) Tatsuya Osaki et al.   Science Advances

Distinct roles for motor neuron autophagy early and late in the SOD1G93Amouse model of ALS

(2017) Noam D. Rudnick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Compartmental microfluidic system for studying muscle–neuron communication and neuromuscular junction maintenance

(2016) Ariel Ionescu et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Microfluidic device for the formation of optically excitable, three-dimensional, compartmentalized motor units

(2016) S. G. M. Uzel et al.   Science Advances

Wireless Optofluidic Systems for Programmable In Vivo Pharmacology and Optogenetics

(2015) Jae-Woong Jeong et al.   CELL

All-optical electrophysiology in mammalian neurons using engineered microbial rhodopsins

(2014) Daniel R Hochbaum et al.   NATURE METHODS

Motor neurone disease

(2014) S. Nageshwaran et al.   BMJ-British Medical Journal

Origin-Dependent Neural Cell Identities in Differentiated Human iPSCs In Vitro and after Transplantation into the Mouse Brain

(2014) Gunnar Hargus et al.   Cell Reports

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Pathophysiological insights into ALS with C9ORF72 expansions

(2013) K. L. Williams et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Microfluidic primary culture model of the lower motor neuron–neuromuscular junction circuit

(2013) Katherine A. Southam et al.   JOURNAL OF NEUROSCIENCE METHODS

Multi-electrode array technologies for neuroscience and cardiology

(2013) Micha E. Spira et al.   Nature Nanotechnology

Genome engineering using the CRISPR-Cas9 system

(2013) F Ann Ran et al.   Nature Protocols

Genetics of neuromuscular disorders

(2012) Nigel G. Laing   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Formation and optogenetic control of engineered 3D skeletal muscle bioactuators

(2012) Mahmut Selman Sakar et al.   LAB ON A CHIP

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Video tracking and analysis of sleep in Drosophila melanogaster

(2012) Giorgio F Gilestro   Nature Protocols

Drug Screening for ALS Using Patient-Specific Induced Pluripotent Stem Cells

(2012) N. Egawa et al.   Science Translational Medicine

Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex

(2011) Tianyi Mao et al.   NEURON

Optogenetics in Neural Systems

(2011) Ofer Yizhar et al.   NEURON

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

Soft lithography for micro- and nanoscale patterning

(2010) Dong Qin et al.   Nature Protocols

High-content screening of primary neurons: ready for prime time

(2009) Aaron Daub et al.   CURRENT OPINION IN NEUROBIOLOGY

Electrophysiology in the age of light

(2009) Massimo Scanziani et al.   NATURE

Sequencing technologies — the next generation

(2009) Michael L. Metzker   NATURE REVIEWS GENETICS

Spinal muscular atrophy

(2008) Mitchell R Lunn et al.   LANCET

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE