Senescent cells: A new Achilles’ heel to exploit for cancer medicine?

The SCN9A channel and plasma membrane depolarization promote cellular senescence through Rb pathway

(2018) Marine Warnier et al.   AGING CELL

Early results of lower dose dasatinib (50 mg daily) as frontline therapy for newly diagnosed chronic-phase chronic myeloid leukemia

(2018) Kiran Naqvi et al.   CANCER

PTBP1-Mediated Alternative Splicing Regulates the Inflammatory Secretome and the Pro-tumorigenic Effects of Senescent Cells

(2018) Athena Georgilis et al.   CANCER CELL

Oncogene-induced senescence mediated by c-Myc requires USP10 dependent deubiquitination and stabilization of p14ARF

(2018) Aram Ko et al.   CELL DEATH AND DIFFERENTIATION

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Two-Step Senescence-Focused Cancer Therapies

(2018) Cynthia J. Sieben et al.   TRENDS IN CELL BIOLOGY

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

(2018) Boyi Zhang et al.   Nature Communications

Chemical screen identifies a geroprotective role of quercetin in premature aging

(2018) Lingling Geng et al.   Protein & Cell

Targeting SPINK1 in the damaged tumour microenvironment alleviates therapeutic resistance

(2018) Fei Chen et al.   Nature Communications

The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration

(2017) Birgit Ritschka et al.   GENES & DEVELOPMENT

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

‘MCC’ protein interacts with E-cadherin and β-catenin strengthening cell–cell adhesion of HCT116 colon cancer cells

(2017) F A Benthani et al.   ONCOGENE

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial and Temporal Control of Senescence

(2017) Yoko Ito et al.   TRENDS IN CELL BIOLOGY

Senescent tumor cells lead the collective invasion in thyroid cancer

(2017) Young Hwa Kim et al.   Nature Communications

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Cellular senescence drives age-dependent hepatic steatosis

(2017) Mikolaj Ogrodnik et al.   Nature Communications

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses

(2016) Servet Özcan et al.   Aging-US

Conserved and novel functions of programmed cellular senescence during vertebrate development

(2016) Hongorzul Davaapil et al.   DEVELOPMENT

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment

(2016) Y Sun et al.   ONCOGENE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Non-Cell-Autonomous Regulation of Cellular Senescence in Cancer

(2016) Diletta Di Mitri et al.   TRENDS IN CELL BIOLOGY

Senescent peritoneal mesothelium creates a niche for ovarian cancer metastases

(2016) Justyna Mikuła-Pietrasik et al.   Cell Death & Disease

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

(2016) N. Tasdemir et al.   Cancer Discovery

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype

(2015) Nicolás Herranz et al.   NATURE CELL BIOLOGY

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation

(2015) Remi-Martin Laberge et al.   NATURE CELL BIOLOGY

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Identification of predictive factors of response to the BH3-mimetic molecule ABT-737: Anex vivoexperiment in human serous ovarian carcinoma

(2014) Stéphanie Lheureux et al.   INTERNATIONAL JOURNAL OF CANCER

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Programmed Cell Senescence during Mammalian Embryonic Development

(2013) Daniel Muñoz-Espín et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Treatment-induced damage to the tumor microenvironment promotes prostate cancer therapy resistance through WNT16B

(2012) Yu Sun et al.   NATURE MEDICINE

Senescence: a new weapon for cancer therapy

(2012) Juan Carlos Acosta et al.   TRENDS IN CELL BIOLOGY

p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype

(2011) Adam Freund et al.   EMBO JOURNAL

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

(2011) Tae-Won Kang et al.   NATURE

DNA Damage-Mediated Induction of a Chemoresistant Niche

(2010) Luke A. Gilbert et al.   CELL

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion

(2010) F. Rodier et al.   JOURNAL OF CELL SCIENCE

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

(2010) Joon-Il Jun et al.   NATURE CELL BIOLOGY

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

(2009) Francis Rodier et al.   NATURE CELL BIOLOGY

Oncogene-Induced Senescence Relayed by an Interleukin-Dependent Inflammatory Network

(2008) Thomas Kuilman et al.   CELL

Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence

(2008) Juan C. Acosta et al.   CELL

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY