A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan

Cardiovascular safety and efficacy of metformin-SGLT2i versus metformin-sulfonylureas in type 2 diabetes: systematic review and meta-analysis of randomized controlled trials

(2021) Desye Gebrie et al.   Scientific Reports

Metformin restores hippocampal neurogenesis and learning and memory via regulating gut microbiota in the obese mouse model

(2021) Xiaoyi Ma et al.   BRAIN BEHAVIOR AND IMMUNITY

Opinion: A better approach for dealing with reproducibility and replicability in science

(2021) James D. Nichols et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucose-Lowering Drugs to Reduce Cardiovascular Risk in Type 2 Diabetes

(2021) Rita R. Kalyani   NEW ENGLAND JOURNAL OF MEDICINE

Therapeutic Potential of Metformin in COVID-19: Reasoning for Its Protective Role

(2021) Samson Mathews Samuel et al.   TRENDS IN MICROBIOLOGY

The Hormetic Effect of Metformin: “Less Is More”?

(2021) Isabella Panfoli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Longitudinal analysis of blood markers reveals progressive loss of resilience and predicts human lifespan limit

(2021) Timothy V. Pyrkov et al.   Nature Communications

Pan-mammalian analysis of molecular constraints underlying extended lifespan

(2020) Amanda Kowalczyk et al.   eLife

Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease.’

(2020) Christopher R. Triggle et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Benefits of Metformin in Attenuating the Hallmarks of Aging

(2020) Ameya S. Kulkarni et al.   Cell Metabolism

Growth/Differentiation Factor-15 (GDF-15): From Biomarker to Novel Targetable Immune Checkpoint

(2020) Jörg Wischhusen et al.   Frontiers in Immunology

ACE2, Metformin, and COVID-19

(2020) Atul Malhotra et al.   iScience

Metformin Use and Risk of All-Cause Mortality and Cardiovascular Events in Patients With Chronic Kidney Disease—A Systematic Review and Meta-Analysis

(2020) Yao Hu et al.   Frontiers in Endocrinology

Use of Metformin and Cardiovascular Effects of New Classes of Glucose-Lowering Agents: A Meta-analysis of Cardiovascular Outcome Trials in Type 2 Diabetes

(2020) Francesco Zaccardi et al.   DIABETES CARE

GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin

(2020) Jing Ouyang et al.   Frontiers in Endocrinology

Can Metformin Exert as an Active Drug on Endothelial Dysfunction in Diabetic Subjects?

(2020) Teresa Salvatore et al.   Biomedicines

Does metformin therapy influence the effects of intensive lifestyle intervention? Exploring the interaction between first line therapies in the look AHEAD trial

(2019) Tasuku Terada et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

ROLE of IGF-1 System in the Modulation of Longevity: Controversies and New Insights From a Centenarians' Perspective

(2019) Giovanni Vitale et al.   Frontiers in Endocrinology

Metformin and gut microbiota: their interactions and their impact on diabetes

(2019) Natalia G. Vallianou et al.   Hormones-International Journal of Endocrinology and Metabolism

Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

(2019) Thomas Bryrup et al.   DIABETOLOGIA

Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet

(2019) Domenico Sergi et al.   Frontiers in Physiology

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

Metformin inhibits metastatic breast cancer progression and improves chemosensitivity by inducing vessel normalization via PDGF-B downregulation

(2019) Ji-Chang Wang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Metformin blunts muscle hypertrophy in response to progressive resistance exercise training in older adults: A randomized, double‐blind, placebo‐controlled, multicenter trial: The MASTERS trial

(2019) R. Grace Walton et al.   AGING CELL

Metformin and Aging: A Review

(2019) Hartmut H. Glossmann et al.   GERONTOLOGY

Metformin as Anti-Aging Therapy: Is It for Everyone?

(2019) Alexander A. Soukas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK

(2019) Yu Wang et al.   Cell Reports

Treatment with a Combination of Metformin and 2-Deoxyglucose Upregulates Thrombospondin-1 in Microvascular Endothelial Cells: Implications in Anti-Angiogenic Cancer Therapy

(2019) Samson Mathews Samuel et al.   Cancers

Pharmacology of metformin – An update

(2019) Hartmut H. Glossmann et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

GDF15 mediates the effects of metformin on body weight and energy balance

(2019) Anthony P. Coll et al.   NATURE

The influence of metformin on IGF-1 levels in humans: A systematic review and meta-analysis

(2019) Xiaodong Yang et al.   PHARMACOLOGICAL RESEARCH

Metformin: The Answer to Cancer in a Flower? Current Knowledge and Future Prospects of Metformin as an Anti-Cancer Agent in Breast Cancer

(2019) Samson Mathews Samuel et al.   Biomolecules

Metformin regulates metabolic and nonmetabolic pathways in skeletal muscle and subcutaneous adipose tissues of older adults

(2018) Ameya S Kulkarni et al.   AGING CELL

Plasma proteomic signature of age in healthy humans

(2018) Toshiko Tanaka et al.   AGING CELL

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress

(2018) Mahmoud El-Daly et al.   VASCULAR PHARMACOLOGY

Moderate Exercise Suppresses NF-κB Signaling and Activates the SIRT1-AMPK-PGC1α Axis to Attenuate Muscle Loss in Diabetic db/db Mice

(2018) Hung-Wen Liu et al.   Frontiers in Physiology

Metformin Use Is Not Associated With B12 Deficiency or Neuropathy in Patients With Type 2 Diabetes Mellitus in Qatar

(2018) Tarik Elhadd et al.   Frontiers in Endocrinology

Association of Body Mass Index With Lifetime Risk of Cardiovascular Disease and Compression of Morbidity

(2018) Sadiya S. Khan et al.   JAMA Cardiology

Challenges and perspectives in the treatment of diabetes associated breast cancer

(2018) Samson Mathews Samuel et al.   CANCER TREATMENT REVIEWS

Long-Term Metformin Usage and Cognitive Function among Older Adults with Diabetes

(2018) Tze Pin Ng et al.   JOURNAL OF ALZHEIMERS DISEASE

Metformin Use Associated with Reduced Risk of Dementia in Patients with Diabetes: A Systematic Review and Meta-Analysis

(2018) Jared M. Campbell et al.   JOURNAL OF ALZHEIMERS DISEASE

Endothelial function and dysfunction: Impact of metformin

(2018) Asma Nafisa et al.   PHARMACOLOGY & THERAPEUTICS

Metformin as an Anticancer Agent

(2018) Ales Vancura et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

How healthy is the healthspan concept?

(2018) Matt Kaeberlein   GeroScience

Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults

(2018) Adam R. Konopka et al.   AGING CELL

Metformin-Induced Mitochondrial Complex I Inhibition: Facts, Uncertainties, and Consequences

(2018) Eric Fontaine   Frontiers in Endocrinology

Metformin Is a Direct SIRT1-Activating Compound: Computational Modeling and Experimental Validation

(2018) Elisabet Cuyàs et al.   Frontiers in Endocrinology

High Levels of SIRT1 Expression as a Protective Mechanism Against Disease-Related Conditions

(2018) Birsen Elibol et al.   Frontiers in Endocrinology

Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15

(2017) Jer-Yuan Hsu et al.   NATURE

Metformin effects on the heart and the cardiovascular system: A review of experimental and clinical data

(2017) L. Nesti et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Metformin – its potential anti-cancer and anti-aging effects

(2017) Monika Podhorecka et al.   Postepy Higieny I Medycyny Doswiadczalnej

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer

(2016) Randy Strong et al.   AGING CELL

Effects of dietary restriction on adipose mass and biomarkers of healthy aging in human

(2016) Daniele Lettieri-Barbato et al.   Aging-US

Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice

(2016) Paul J. Gasser et al.   Brain Structure & Function

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

(2016) Lianfeng Wu et al.   CELL

Metformin as a Tool to Target Aging

(2016) Nir Barzilai et al.   Cell Metabolism

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

(2016) Navdeep S. Chandel et al.   Cell Metabolism

AMPK Activation by Metformin Suppresses Abnormal Extracellular Matrix Remodeling in Adipose Tissue and Ameliorates Insulin Resistance in Obesity

(2016) Ting Luo et al.   DIABETES

Metformin Suppresses Diabetes-Accelerated Atherosclerosis via the Inhibition of Drp1-Mediated Mitochondrial Fission

(2016) Qilong Wang et al.   DIABETES

Metformin Effect on Nontargeted Metabolite Profiles in Patients With Type 2 Diabetes and in Multiple Murine Tissues

(2016) Jonathan Adam et al.   DIABETES

Growth Differentiation Factor 15 as a Novel Biomarker for Metformin

(2016) Hertzel C. Gerstein et al.   DIABETES CARE

Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? Yes, They Should Be Relaxed! What’s the Fuss?: Table 1

(2016) George L. Bakris et al.   DIABETES CARE

Should Restrictions Be Relaxed for Metformin Use in Chronic Kidney Disease? No, We Should Never Again Compromise Safety!

(2016) Kamyar Kalantar-Zadeh et al.   DIABETES CARE

Metformin and the gastrointestinal tract

(2016) Laura J. McCreight et al.   DIABETOLOGIA

Impact of Metformin on Exercise-Induced Metabolic Adaptations to Lower Type 2 Diabetes Risk

(2016) Steven K. Malin et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells

(2016) Hao Cai et al.   INTERNATIONAL JOURNAL OF CANCER

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

(2016) Vanita R. Aroda et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The role of sirtuins in cellular homeostasis

(2016) Wioleta Kupis et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

(2016) Aiyun Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

1,500 scientists lift the lid on reproducibility

(2016) Monya Baker   NATURE

Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling

(2016) Chunying Li et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Exercise Modulates Oxidative Stress and Inflammation in Aging and Cardiovascular Diseases

(2016) Nada Sallam et al.   Oxidative Medicine and Cellular Longevity

Activation of autophagy flux by metformin downregulates cellular FLICE–like inhibitory protein and enhances TRAIL- induced apoptosis

(2016) Uddin Nazim et al.   Oncotarget

New insights into the anti-diabetic actions of metformin: from the liver to the gut

(2016) Tongzhi Wu et al.   Expert Review of Gastroenterology & Hepatology

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice

(2016) Vladimir N. Anisimov et al.   Aging-US

MATE2 Expression Is Associated with Cancer Cell Response to Metformin

(2016) Sanjana Chowdhury et al.   PLoS One

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

Metformin improves endothelial function in aortic tissue and microvascular endothelial cells subjected to diabetic hyperglycaemic conditions

(2015) Suparna Ghosh et al.   BIOCHEMICAL PHARMACOLOGY

Targeting LKB1 in cancer – exposing and exploiting vulnerabilities

(2015) M Momcilovic et al.   BRITISH JOURNAL OF CANCER

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

Identifying Novel Biomarkers for Cardiovascular Events or Death in People With DysglycemiaClinical Perspective

(2015) Hertzel C. Gerstein et al.   CIRCULATION

The Primary Glucose-Lowering Effect of Metformin Resides in the Gut, Not the Circulation. Results From Short-term Pharmacokinetic and 12-Week Dose-Ranging Studies

(2015) John B. Buse et al.   DIABETES CARE

Steady-state pharmacokinetics of metformin is independent of the OCT1 genotype in healthy volunteers

(2015) Mette Marie Hougaard Christensen et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

(2015) Mustafa Kinaan et al.   MEDICAL PRINCIPLES AND PRACTICE

Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

(2015) Kristoffer Forslund et al.   NATURE

Metformin activates a duodenal Ampk–dependent pathway to lower hepatic glucose production in rats

(2015) Frank A Duca et al.   NATURE MEDICINE

Type 2 Diabetes and Breast Cancer: The Interplay between Impaired Glucose Metabolism and Oxidant Stress

(2015) Patrizia Ferroni et al.   Oxidative Medicine and Cellular Longevity

Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases

(2015) B. K. Pedersen et al.   SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS

GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective

(2015) Ramu Adela et al.   Journal of Diabetes Research

Metformin Use Reduction in Mild to Moderate Renal Impairment

(2015) James H. Flory et al.   JAMA Internal Medicine

Metformin Acts on Two Different Molecular Pathways to Enhance Adult Neural Precursor Proliferation/Self-Renewal and Differentiation

(2015) Michael Fatt et al.   Stem Cell Reports

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

(2015) Yoshifumi Saisho   Endocrine Metabolic & Immune Disorders-Drug Targets

Hypercholesterolemia Induces Angiogenesis and Accelerates Growth of Breast Tumors in Vivo

(2014) Kristine Pelton et al.   AMERICAN JOURNAL OF PATHOLOGY

Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

(2014) Young Mi Song et al.   Autophagy

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

The anti-proliferative effect of metformin in triple-negative MDA-MB-231 breast cancer cells is highly dependent on glucose concentration: Implications for cancer therapy and prevention

(2014) Beshay N.M. Zordoky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Metformin and Cancer Risk and Mortality: A Systematic Review and Meta-analysis Taking into Account Biases and Confounders

(2014) S. Gandini et al.   Cancer Prevention Research

The Search for Antiaging Interventions: From Elixirs to Fasting Regimens

(2014) Rafael de Cabo et al.   CELL

Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

(2014) Min Guo et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study

(2014) Tanja Dujic et al.   DIABETES

Metformin and Cancer: Mounting Evidence Against an Association: Figure 1

(2014) Samy Suissa et al.   DIABETES CARE

Incidence of Bladder Cancer in Patients With Type 2 Diabetes Treated With Metformin or Sulfonylureas

(2014) Ronac Mamtani et al.   DIABETES CARE

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

(2014) C. A. Bannister et al.   DIABETES OBESITY & METABOLISM

Diabetes and cancer: 5years into the recent controversy

(2014) Ellena Badrick et al.   EUROPEAN JOURNAL OF CANCER

Metformin in Patients With Type 2 Diabetes and Kidney Disease

(2014) Silvio E. Inzucchi et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex

(2014) Shumei Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer

(2014) Vijayalekshmi Nair et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type 2 Diabetes and Antidiabetic Medications in Relation to Dementia Diagnosis

(2014) Chin Cheng et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

(2014) W. De Haes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1 

(2014) B. Faubert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of GLP-1 on appetite and weight

(2014) Meera Shah et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Colorectal and Prostate Cancer Risk in Diabetes: Metformin, an Actor behind the Scene

(2014) M. Akhtar Anwar et al.   Journal of Cancer

Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

(2013) Olga Moiseeva et al.   AGING CELL

Epigenetic signatures and vascular risk in type 2 diabetes: A clinical perspective

(2013) Francesco Paneni et al.   ATHEROSCLEROSIS

Metformin modulates hyperglycaemia-induced endothelial senescence and apoptosis through SIRT1

(2013) Gnanapragasam Arunachalam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Glucose promotes breast cancer aggression and reduces metformin efficacy

(2013) Reema Wahdan-Alaswad et al.   CELL CYCLE

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Mitochondria and Endothelial Function

(2013) Matthew A. Kluge et al.   CIRCULATION RESEARCH

Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa

(2013) Bradley J. Willcox et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

SIRT1, p66Shc, and Set7/9 in Vascular Hyperglycemic Memory: Bringing All the Strands Together

(2013) F. Paneni et al.   DIABETES

AMPK: A Target for Drugs and Natural Products With Effects on Both Diabetes and Cancer

(2013) D. G. Hardie   DIABETES

The Role of Metformin in Metformin-Associated Lactic Acidosis (MALA): Case Series and Formulation of a Model of Pathogenesis

(2013) Janna K. Duong et al.   DRUG SAFETY

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term effects of metformin on endothelial function in type 2 diabetes: a randomized controlled trial

(2013) J. de Jager et al.   JOURNAL OF INTERNAL MEDICINE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth

(2013) H. A. Hirsch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overexpression of Atg5 in mice activates autophagy and extends lifespan

(2013) Jong-Ok Pyo et al.   Nature Communications

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Metformin: an old but still the best treatment for type 2 diabetes

(2013) Lilian Beatriz Aguayo Rojas et al.   Diabetology & Metabolic Syndrome

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

(2013) Hayley M. O'Neill   Diabetes & Metabolism Journal

Rapamycin-induced glucose intolerance: Hunger or starvation diabetes

(2012) Mikhail V Blagosklonny   CELL CYCLE

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

The Critical Role of Metabolic Pathways in Aging

(2012) N. Barzilai et al.   DIABETES

Long-Term Safety, Tolerability, and Weight Loss Associated With Metformin in the Diabetes Prevention Program Outcomes Study

(2012)   DIABETES CARE

The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK

(2012) Yan-yan Zhan et al.   Nature Chemical Biology

Metformin pathways

(2012) Li Gong et al.   Pharmacogenetics and Genomics

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

(2012) D. W. Lamming et al.   SCIENCE

AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

(2011) Antero Salminen et al.   AGEING RESEARCH REVIEWS

Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer

(2011) Soley Bayraktar et al.   CANCER

Autophagy and Aging

(2011) David C. Rubinsztein et al.   CELL

Metformin slows down aging and extends life span of female SHR mice

(2011) Vladimir N. Anisimov et al.   CELL CYCLE

TOR-driven aging: Speeding car without brakes

(2011) Mikhail V Blagosklonny   CELL CYCLE

Clinical Pharmacokinetics of Metformin

(2011) Garry G. Graham et al.   CLINICAL PHARMACOKINETICS

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

Sirtuin 1-Mediated Cellular Metabolic Memory of High Glucose Via the LKB1/AMPK/ROS Pathway and Therapeutic Effects of Metformin

(2011) Z. Zheng et al.   DIABETES

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Association of Biochemical B12 Deficiency With Metformin Therapy and Vitamin B12 Supplements: The National Health and Nutrition Examination Survey, 1999-2006

(2011) L. Reinstatler et al.   DIABETES CARE

Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration

(2011) S. Larsen et al.   DIABETOLOGIA

Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status

(2011) X. Stephenne et al.   DIABETOLOGIA

Effect of Metformin Therapy on Vitamin D and Vitamin B12Levels in Patients with Type 2 Diabetes Mellitus

(2011) Elizabeth Kos et al.   Endocrine Practice

Gait Speed and Survival in Older Adults

(2011) Stephanie Studenski   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Calorie Restriction: Is AMPK a Key Sensor and Effector?

(2011) Carles Cantó et al.   PHYSIOLOGY

Prolonged Hemodialysis for Severe Metformin Intoxication

(2011) Stephen I. Rifkin et al.   RENAL FAILURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

(2010) Yi Zu et al.   CIRCULATION RESEARCH

Diabetes and Cancer: A consensus report

(2010) E. Giovannucci et al.   DIABETES CARE

Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer

(2010) Murielle Mimeault et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin Supplementation and Life Span in Fischer-344 Rats

(2010) D. L. Smith et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Metformin Induces a Dietary Restriction–Like State and the Oxidative Stress Response to Extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

(2010) Brian Onken et al.   PLoS One

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity

(2009) Vladimir B. Ritov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities

(2009) William I. Sivitz et al.   ANTIOXIDANTS & REDOX SIGNALING

Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells

(2009) Beate Fisslthaler et al.   CIRCULATION RESEARCH

High glucose increases expression of cyclooxygenase-2, increases oxidative stress and decreases the generation of nitric oxide in mouse microvessel endothelial cells

(2009) Mohamad Aljofan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

(2008) Randy  Strong et al.   AGING CELL

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Phosphorylation of LKB1 at Serine 428 by Protein Kinase C-ζ Is Required for Metformin-Enhanced Activation of the AMP-Activated Protein Kinase in Endothelial Cells

(2008) Zhonglin Xie et al.   CIRCULATION

Metformin and the intestine

(2008) C. J. Bailey et al.   DIABETOLOGIA

10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY

Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro

(2008) James A. Dykens et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY