Chemical screening identifies ATM as a target for alleviating senescence

A Synergistic Dysfunction of Mitochondrial Fission/Fusion Dynamics and Mitophagy in Alzheimer's Disease

(2017) Renato X. Santos et al.   JOURNAL OF ALZHEIMERS DISEASE

Defective DNA single-strand break repair is responsible for senescence and neoplastic escape of epithelial cells

(2016) Joe Nassour et al.   Nature Communications

DNA damaging agents and p53 do not cause senescence in quiescent cells, while consecutive re-activation of mTOR is associated with conversion to senescence

(2016) Olga V. Leontieva et al.   Aging-US

A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications

(2015) Sujuan Guo et al.   Autophagy

Mitochondrial Mechanisms in Septic Cardiomyopathy

(2015) María Cimolai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ATM and ATR signaling at a glance

(2015) P. Awasthi et al.   JOURNAL OF CELL SCIENCE

ATM and ATR as therapeutic targets in cancer

(2015) Anika Maria Weber et al.   PHARMACOLOGY & THERAPEUTICS

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

(2015) E. H. Blackburn et al.   SCIENCE

Construction of phosphorylation interaction networks by text mining of full-length articles using the eFIP system

(2015) Catalina O. Tudor et al.   Database-The Journal of Biological Databases and Curation

ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres

(2015) Adrian S. Tong et al.   Cell Reports

ATM Kinase Is Required for Telomere Elongation in Mouse and Human Cells

(2015) Stella Suyong Lee et al.   Cell Reports

Mitochondrial iron–sulfur protein biogenesis and human disease

(2014) Oliver Stehling et al.   BIOCHIMIE

Measurement of DNA Concentration as a Normalization Strategy for Metabolomic Data from Adherent Cell Lines

(2013) Leslie P. Silva et al.   ANALYTICAL CHEMISTRY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Mitochondria in ageing: there is metabolism beyond the ROS

(2013) Michael Breitenbach et al.   FEMS YEAST RESEARCH

RanBPM Protein Acts as a Negative Regulator of BLT2 Receptor to Attenuate BLT2-mediated Cell Motility

(2013) Jun-Dong Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Subunit Interactions at the V1-VoInterface in Yeast Vacuolar ATPase

(2012) Rebecca A. Oot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

(2012) Adam L. Hughes et al.   NATURE

Structure of the vacuolar-type ATPase from Saccharomyces cerevisiae at 11-Å resolution

(2012) Samir Benlekbir et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Conserved cysteine residues in the mammalian lamin A tail are essential for cellular responses to ROS generation

(2011) Vanja Pekovic et al.   AGING CELL

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Lysosomal pH and analysis of the counter ion pathways that support acidification

(2011) Jessica E. DiCiccio et al.   JOURNAL OF GENERAL PHYSIOLOGY

Autophagy Impairment Induces Premature Senescence in Primary Human Fibroblasts

(2011) Hyun Tae Kang et al.   PLoS One

Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells

(2011) K. Cao et al.   Science Translational Medicine

The metabolic footprint of aging in mice

(2011) Riekelt H. Houtkooper et al.   Scientific Reports

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Nicotinamide enhances mitochondria quality through autophagy activation in human cells

(2009) Hyun Tae Kang et al.   AGING CELL

A comparative analysis of the cell biology of senescence and aging

(2009) Eun Seong Hwang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Unimpaired Lysosomal Acidification in Respiratory Epithelial Cells in Cystic Fibrosis

(2009) Peter M. Haggie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion

(2009) S. E. Golding et al.   MOLECULAR CANCER THERAPEUTICS

Human Proline-Rich Nuclear Receptor Coregulatory Protein 2 Mediates an Interaction between mRNA Surveillance Machinery and Decapping Complex

(2009) Hana Cho et al.   MOLECULAR CELL

Lysosomes and oxidative stress in aging and apoptosis

(2008) Tino Kurz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Deferiprone targets aconitase: Implication for Friedreich's ataxia treatment

(2008) Sergio Goncalves et al.   BMC Neurology

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL