The Role of the BCL-2 Family of Proteins in HIV-1 Pathogenesis and Persistence

Modeling HIV-1 latency using primary CD4+ T cells from HIV-1 infected ART suppressed individuals

(2019) Hiroshi Takata et al.   JOURNAL OF VIROLOGY

Naïve CD4+ T Cells Harbor a Large Inducible Reservoir of Latent, Replication-Competent HIV-1

(2019) Jennifer M Zerbato et al.   CLINICAL INFECTIOUS DISEASES

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

(2018) Lorenzo Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Getting the “Kill” into “Shock and Kill”: Strategies to Eliminate Latent HIV

(2018) Youry Kim et al.   Cell Host & Microbe

Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents

(2018) Yichao Wan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The role of latency reversal agents in the cure of HIV: A review of current data

(2018) Kiandokht Bashiri et al.   IMMUNOLOGY LETTERS

Latent HIV reservoirs exhibit inherent resistance to elimination by CD8+ T cells

(2018) Szu-Han Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

HIV Protease-Generated Casp8p41, When Bound and Inactivated by Bcl2, Is Degraded by the Proteasome

(2018) Sekar Natesampillai et al.   JOURNAL OF VIROLOGY

Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection

(2017) Clovis S. Palmer et al.   FEBS LETTERS

CTLA-4 + PD-1 − Memory CD4 + T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques

(2017) Colleen S. McGary et al.   IMMUNITY

Caspase-8: regulating life and death

(2017) Bart Tummers et al.   IMMUNOLOGICAL REVIEWS

Interval dosing with the HDAC inhibitor vorinostat effectively reverses HIV latency

(2017) Nancie M. Archin et al.   JOURNAL OF CLINICAL INVESTIGATION

Clonal expansion of genome-intact HIV-1 in functionally polarized Th1 CD4+ T cells

(2017) Guinevere Q. Lee et al.   JOURNAL OF CLINICAL INVESTIGATION

Maintenance of the HIV Reservoir Is Antagonized by Selective BCL2 Inhibition

(2017) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

(2017) Avi Ashkenazi et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of Genetically Intact HIV-1 Proviruses in Specific CD4 + T Cells from Effectively Treated Participants

(2017) Bonnie Hiener et al.   Cell Reports

HIV-related proteins prolong macrophage survival through induction of Triggering receptor expressed on myeloid cells-1

(2017) Zhihong Yuan et al.   Scientific Reports

HIV-infected macrophages and microglia that survive acute infection become viral reservoirs by a mechanism involving Bim

(2017) Paul Castellano et al.   Scientific Reports

Inflammation Perturbs the IL-7 Axis, Promoting Senescence and Exhaustion that Broadly Characterize Immune Failure in Treated HIV Infection

(2016) Carey L. Shive et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

(2016) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cytokines and T-Cell Homeostasis in HIV Infection

(2016) Michael L. Freeman et al.   JOURNAL OF INFECTIOUS DISEASES

Prime, Shock, and Kill: Priming CD4 T Cells from HIV Patients with a BCL-2 Antagonist before HIV Reactivation Reduces HIV Reservoir Size

(2016) Nathan W. Cummins et al.   JOURNAL OF VIROLOGY

HIV Integration Site Analysis of Cellular Models of HIV Latency with a Probe-Enriched Next-Generation Sequencing Assay

(2016) Sara Sunshine et al.   JOURNAL OF VIROLOGY

PD-1+ and follicular helper T cells are responsible for persistent HIV-1 transcription in treated aviremic individuals

(2016) Riddhima Banga et al.   NATURE MEDICINE

Distinct Patterns of Bcl-2 Expression Occur in R5- and X4-Tropic HIV-1-Producing Lymphoid Tissue Cells Infected Ex Vivo

(2015) Michelle K. Haas et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer

(2015) Wataru Nakajima et al.   CANCER BIOLOGY & THERAPY

BCL-2 Antagonism to Target the Intrinsic Mitochondrial Pathway of Apoptosis

(2015) C. J. Gibson et al.   CLINICAL CANCER RESEARCH

A Subset of CD4/CD8 Double-Negative T Cells Expresses HIV Proteins in Patients on Antiretroviral Therapy

(2015) Laura K. DeMaster et al.   JOURNAL OF VIROLOGY

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

T Memory Stem Cells and HIV: a Long-Term Relationship

(2015) Ann Chahroudi et al.   Current HIV/AIDS Reports

HIV-1 Tat affects the programming and functionality of human CD8+ T cells by modulating the expression of T-box transcription factors

(2014) Fabio Sforza et al.   AIDS

Triggering Receptor Expressed on Myeloid Cells 1 (TREM-1)-mediated Bcl-2 Induction Prolongs Macrophage Survival

(2014) Zhihong Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation

(2014) Amy M. Sainski et al.   JOURNAL OF CELL BIOLOGY

An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency

(2014) A. Marini et al.   JOURNAL OF IMMUNOLOGY

Tat-Induced FOXO3a Is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T Lymphocytes

(2014) A. Dabrowska et al.   JOURNAL OF IMMUNOLOGY

Inflammatory Cytokines Drive CD4+ T-Cell Cycling and Impaired Responsiveness to Interleukin 7: Implications for Immune Failure in HIV Disease

(2014) Carey L. Shive et al.   JOURNAL OF INFECTIOUS DISEASES

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

(2014) Netanya G. Sandler et al.   NATURE

HIV-1 persistence in CD4+ T cells with stem cell–like properties

(2014) Maria J Buzon et al.   NATURE MEDICINE

A primary CD4+ T cell model of HIV-1 latency established after activation through the T cell receptor and subsequent return to quiescence

(2014) Michelle Kim et al.   Nature Protocols

Necroptosis Takes Place in Human Immunodeficiency Virus Type-1 (HIV-1)-Infected CD4+ T Lymphocytes

(2014) Ting Pan et al.   PLoS One

Progressive contraction of the latent HIV reservoir around a core of less-differentiated CD4+ memory T Cells

(2014) S. Jaafoura et al.   Nature Communications

Apoptosis and Molecular Targeting Therapy in Cancer

(2014) Mohamed Hassan et al.   Biomed Research International

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

Replication-Competent Noninduced Proviruses in the Latent Reservoir Increase Barrier to HIV-1 Cure

(2013) Ya-Chi Ho et al.   CELL

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Cancer therapeutics: Targeting the apoptotic pathway

(2013) Khurum H. Khan et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Presence of HIV-1 Tat Protein Second Exon Delays Fas Protein-mediated Apoptosis in CD4+T Lymphocytes

(2013) María Rosa López-Huertas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Programmed Death-1 Is a Marker for Abnormal Distribution of Naive/Memory T Cell Subsets in HIV-1 Infection

(2013) G. Breton et al.   JOURNAL OF IMMUNOLOGY

HIV-Specific CD8+ T Cells from Elite Controllers Are Primed for Survival

(2013) J. Yan et al.   JOURNAL OF VIROLOGY

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Interferon-α Is the Primary Plasma Type-I IFN in HIV-1 Infection and Correlates with Immune Activation and Disease Markers

(2013) Gareth A. D. Hardy et al.   PLoS One

Proteasome inhibitors act as bifunctional antagonists of human immunodeficiency virus type 1 latency and replication

(2013) Leia K Miller et al.   Retrovirology

Multiple Functions of BCL-2 Family Proteins

(2013) J. M. Hardwick et al.   Cold Spring Harbor Perspectives in Biology

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Type I Interferon Upregulates Bak and Contributes to T Cell Loss during Human Immunodeficiency Virus (HIV) Infection

(2013) Joseph A. Fraietta et al.   PLoS Pathogens

Regulation of the Intrinsic Apoptosis Pathway by Reactive Oxygen Species

(2012) Chu-Chiao Wu et al.   ANTIOXIDANTS & REDOX SIGNALING

Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and production

(2012) Matthieu Perreau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Shock and kill

(2012) Steven G. Deeks   NATURE

CCL21/CCR7 Prevents Apoptosis via the ERK Pathway in Human Non-Small Cell Lung Cancer Cells

(2012) Ying Xu et al.   PLoS One

HIV-1 Induced Bystander Apoptosis

(2012) Himanshu Garg et al.   Viruses-Basel

Directly Infected Resting CD4+T Cells Can Produce HIV Gag without Spreading Infection in a Model of HIV Latency

(2012) Matthew J. Pace et al.   PLoS Pathogens

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

Virally induced changes in cellular microRNAs maintain latency of human cytomegalovirus in CD34+ progenitors

(2011) E. Poole et al.   JOURNAL OF GENERAL VIROLOGY

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

A human memory T cell subset with stem cell–like properties

(2011) Luca Gattinoni et al.   NATURE MEDICINE

Expression and reactivation of HIV in a chemokine induced model of HIV latency in primary resting CD4+ T cells

(2011) Suha Saleh et al.   Retrovirology

Myeloid dendritic cells in HIV-1 infection

(2011) Nina Derby et al.   Current Opinion in HIV and AIDS

ABT-737 synergizes with Bortezomib to kill melanoma cells

(2011) S. N. Reuland et al.   Biology Open

Acquired resistance to ABT-737 in lymphoma cells that up-regulate MCL-1 and BFL-1

(2010) D. Yecies et al.   BLOOD

Both CD31+and CD31−Naive CD4+T Cells Are Persistent HIV Type 1–Infected Reservoirs in Individuals Receiving Antiretroviral Therapy

(2010) Fiona Wightman et al.   JOURNAL OF INFECTIOUS DISEASES

Blood Myeloid Dendritic Cells from HIV-1-Infected Individuals Display a Proapoptotic Profile Characterized by Decreased Bcl-2 Levels and by Caspase-3+ Frequencies That Are Associated with Levels of Plasma Viremia and T Cell Activation in an Exploratory Study

(2010) S. M. Dillon et al.   JOURNAL OF VIROLOGY

BH3-Triggered Structural Reorganization Drives the Activation of Proapoptotic BAX

(2010) Evripidis Gavathiotis et al.   MOLECULAR CELL

HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs

(2010) Christoph C Carter et al.   NATURE MEDICINE

Autophagy and HIV

(2010) Christina Dinkins et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mechanisms of HIV-associated lymphocyte apoptosis: 2010

(2010) N W Cummins et al.   Cell Death & Disease

Antiretroviral therapy initiation during primary HIV infection enhances both CD127 expression and the proliferative capacity of HIV-specific CD8+ T cells

(2009) Camille Lécuroux et al.   AIDS

BAKandBAXdeletion using zinc-finger nucleases yields apoptosis-resistant CHO cells

(2009) Gregory J. Cost et al.   BIOTECHNOLOGY AND BIOENGINEERING

IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells

(2009) M. A. Brockman et al.   BLOOD

Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells

(2009) M Kochetkova et al.   CELL DEATH AND DIFFERENTIATION

Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages

(2009) George B. Kyei et al.   JOURNAL OF CELL BIOLOGY

Small-molecule screening using a human primary cell model of HIV latency identifies compounds that reverse latency without cellular activation

(2009) Hung-Chih Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Stepwise Activation of BAX and BAK by tBID, BIM, and PUMA Initiates Mitochondrial Apoptosis

(2009) Hyungjin Kim et al.   MOLECULAR CELL

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

(2009) Nicolas Chomont et al.   NATURE MEDICINE

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

S-phase entry leads to cell death in circulating T cells from HIV-infected persons

(2008) S. F. Sieg et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Tumor transfected with CCL21 enhanced reactivity and apoptosis resistance of human monocyte-derived dendritic cells

(2007) Sha Wu et al.   IMMUNOBIOLOGY