Inhibition of Heat Shock Protein 90 Prevents HIV Rebound

Oral Administration of the Nucleoside EFdA (4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine) Provides Rapid Suppression of HIV Viremia in Humanized Mice and Favorable Pharmacokinetic Properties in Mice and the Rhesus Macaque

(2015) Cheryl A. Stoddart et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Therapeutic doses of irradiation activate viral transcription and induce apoptosis in HIV-1 infected cells

(2015) Sergey Iordanskiy et al.   VIROLOGY

Investigating the Role of F-Actin in Human Immunodeficiency Virus Assembly by Live-Cell Microscopy

(2014) Sheikh Abdul Rahman et al.   JOURNAL OF VIROLOGY

Heat shock protein 90 controls HIV-1 reactivation from latency

(2014) I. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional control of HIV latency: Cellular signaling pathways, epigenetics, happenstance and the hope for a cure

(2014) Uri Mbonye et al.   VIROLOGY

Heat Shock Protein 90 Is Critical for Regulation of Phenotype and Functional Activity of Human T Lymphocytes and NK Cells

(2013) J. Bae et al.   JOURNAL OF IMMUNOLOGY

The role of mutational robustness in RNA virus evolution

(2013) Adam S. Lauring et al.   NATURE REVIEWS MICROBIOLOGY

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

(2013) J. A. Horwitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice

(2013) E Ikebe et al.   Blood Cancer Journal

Tracking replication-competent HIV reservoirs in infected individuals

(2013) Tae-Wook Chun   Current Opinion in HIV and AIDS

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

The transcription cycle in eukaryotes: From productive initiation to RNA polymerase II recycling

(2012) Jayasha Shandilya et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Virus-producing cells determine the host protein profiles of HIV-1 virion cores

(2012) Steven Santos et al.   Retrovirology

Heat shock protein 90AB1 and hyperthermia rescue infectivity of HIV with defective cores

(2012) Pheroze Joshi et al.   VIROLOGY

Hyperthermia Stimulates HIV-1 Replication

(2012) Ferdinand Roesch et al.   PLoS Pathogens

Advances in the clinical development of heat shock protein 90 (Hsp90) inhibitors in cancers

(2011) Komal Jhaveri et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The ‘active life’ of Hsp90 complexes

(2011) Chrisostomos Prodromou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The Hsp90 chaperone machinery: Conformational dynamics and regulation by co-chaperones

(2011) Jing Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Broad action of Hsp90 as a host chaperone required for viral replication

(2011) Ron Geller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The heat shock protein 90 inhibitor, AT13387, displays a long duration of action in vitro and in vivo in non-small cell lung cancer

(2011) Brent Graham et al.   CANCER SCIENCE

HSP90 inhibition: two-pronged exploitation of cancer dependencies

(2011) Jon Travers et al.   DRUG DISCOVERY TODAY

Impaired Infectivity of Ritonavir-resistant HIV Is Rescued by Heat Shock Protein 90AB1

(2011) Pheroze Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV reservoirs and the possibility of a cure for HIV infection

(2011) S. Palmer et al.   JOURNAL OF INTERNAL MEDICINE

Conformational dynamics of the molecular chaperone Hsp90

(2011) Kristin A. Krukenberg et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD-scid IL-2Rγ−/− (NSG) BLT mice

(2011) Cheryl A. Stoddart et al.   VIROLOGY

Gyrase B Inhibitor Impairs HIV-1 Replication by Targeting Hsp90 and the Capsid Protein

(2010) Luciano Vozzolo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

(2010) Tilman Schneider-Poetsch et al.   Nature Chemical Biology

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

(2010) Mikko Taipale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

HIV Persistence and the Prospect of Long-Term Drug-Free Remissions for HIV-Infected Individuals

(2010) D. Trono et al.   SCIENCE

Organization of Transcription

(2010) L. Chakalova et al.   Cold Spring Harbor Perspectives in Biology

Protein Folding in the Cytoplasm and the Heat Shock Response

(2010) R. M. Vabulas et al.   Cold Spring Harbor Perspectives in Biology

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of Inhibition of HIV-1 Reverse Transcriptase by 4′-Ethynyl-2-fluoro-2′-deoxyadenosine Triphosphate, a Translocation-defective Reverse Transcriptase Inhibitor

(2009) Eleftherios Michailidis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis

(2008) S. A. Eccles et al.   CANCER RESEARCH

Molecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy

(2008) Len Neckers et al.   Cell Host & Microbe