Induction of a Senescence-Like Phenotype in Cultured Human Fetal Microglia During HIV-1 Infection

Targeting metabolism in cellular senescence, a role for intervention

(2017) Timothy Nacarelli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

The Role of Caveolin 1 in HIV Infection and Pathogenesis

(2017) Ayalew Mergia   Viruses-Basel

Astrocyte Senescence and Metabolic Changes in Response to HIV Antiretroviral Therapy Drugs

(2017) Justin Cohen et al.   Frontiers in Aging Neuroscience

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype

(2016) Christopher D. Wiley et al.   Cell Metabolism

Fate of microglia during HIV-1 infection: From activation to senescence?

(2016) Natalie C. Chen et al.   GLIA

Dark microglia: A new phenotype predominantly associated with pathological states

(2016) Kanchan Bisht et al.   GLIA

HIV-1 Infection Dysregulates Cell Cycle Regulatory Protein p21 in CD4+ T Cells Through miR-20a and miR-106b Regulation

(2016) Debjani Guha et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

HIV alters neuronal mitochondrial fission/fusion in the brain during HIV-associated neurocognitive disorders

(2016) Jerel Adam Fields et al.   NEUROBIOLOGY OF DISEASE

Mitochondria: Are they causal players in cellular senescence?

(2015) Clara Correia-Melo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

An Aβ42 uptake and degradation via Rg3 requires an activation of caveolin, clathrin and Aβ-degrading enzymes in microglia

(2015) Su Kil Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

HIV-1 Infection Accelerates Age According to the Epigenetic Clock

(2015) Steve Horvath et al.   JOURNAL OF INFECTIOUS DISEASES

p53-Derived Host Restriction of HIV-1 Replication by Protein Kinase R-Mediated Tat Phosphorylation and Inactivation

(2015) Cheol-Hee Yoon et al.   JOURNAL OF VIROLOGY

Acceleration of Age-Associated Methylation Patterns in HIV-1-Infected Adults

(2015) Tammy M. Rickabaugh et al.   PLoS One

Absolute Leukocyte Telomere Length in HIV-Infected and Uninfected Individuals: Evidence of Accelerated Cell Senescence in HIV-Associated Chronic Obstructive Pulmonary Disease

(2015) Joseph C. Y. Liu et al.   PLoS One

Mitochondrial effectors of cellular senescence: beyond the free radical theory of aging

(2014) Dorian V. Ziegler et al.   AGING CELL

Cellular senescence and its effector programs

(2014) R. Salama et al.   GENES & DEVELOPMENT

Cellular senescence: from physiology to pathology

(2014) Daniel Muñoz-Espín et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Asymptomatic HIV-associated neurocognitive impairment increases risk for symptomatic decline

(2014) I. Grant et al.   NEUROLOGY

Oxidative Stress Induces Mitochondrial Dysfunction in a Subset of Autism Lymphoblastoid Cell Lines in a Well-Matched Case Control Cohort

(2014) Shannon Rose et al.   PLoS One

Microglia change from a reactive to an age-like phenotype with the time in culture

(2014) Cláudia Caldeira et al.   Frontiers in Cellular Neuroscience

HIV Associated Neurocognitive Disorders in the Modern Antiviral Treatment Era: Prevalence, Characteristics, Biomarkers, and Effects of Treatment

(2014) Phillip Chan et al.   Current HIV/AIDS Reports

Redox Control of the Senescence Regulator Interleukin-1α and the Secretory Phenotype

(2013) Donald A. McCarthy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

(2013) S. J. Chinta et al.   JOURNAL OF INTERNAL MEDICINE

Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia

(2013) Ingrid R. Niesman et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Age-Associated Changes in Monocyte and Innate Immune Activation Markers Occur More Rapidly in HIV Infected Women

(2013) Genevieve E. Martin et al.   PLoS One

Accelerated Aging in HIV/AIDS: Novel Biomarkers of Senescent Human CD8+ T Cells

(2013) Jennifer P. Chou et al.   PLoS One

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

(2013) Wai T. Wong   Frontiers in Cellular Neuroscience

Suppression of Nucleotide Metabolism Underlies the Establishment and Maintenance of Oncogene-Induced Senescence

(2013) Katherine M. Aird et al.   Cell Reports

Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

(2012) Diana Jurk et al.   AGING CELL

Purinergic receptors in microglia: Functional modal shifts of microglia mediated by P2 and P1 receptors

(2012) Schuichi Koizumi et al.   GLIA

Phenotyping primary human microglia: Tight regulation of LPS responsiveness

(2012) Jeroen Melief et al.   GLIA

Astrocyte Senescence as a Component of Alzheimer’s Disease

(2012) Rekha Bhat et al.   PLoS One

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

Caveolin-1, cellular senescence and age-related diseases

(2011) Huafei Zou et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional

(2011) G Lossaint et al.   ONCOGENE

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Stress-induced senescence in human and rodent astrocytes

(2010) Alessandro Bitto et al.   EXPERIMENTAL CELL RESEARCH

Microglial activation in healthy aging

(2010) Alie Schuitemaker et al.   NEUROBIOLOGY OF AGING

Ubiquitin-independent p53 proteasomal degradation

(2009) P Tsvetkov et al.   CELL DEATH AND DIFFERENTIATION

Diminished Pancreatic β-Cell Mass in Securin-Null Mice Is Caused by β-Cell Apoptosis and Senescence

(2009) Vera Chesnokova et al.   ENDOCRINOLOGY

A crucial role for adipose tissue p53 in the regulation of insulin resistance

(2009) Tohru Minamino et al.   NATURE MEDICINE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA