Molecular modelling of the FOXO4-TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

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Selective elimination of senescent cells by mitochondrial targeting is regulated by ANT2

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An intrinsic S/G2 checkpoint enforced by ATR

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The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Phenotype characterization of human melanoma cells resistant to dabrafenib

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CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers

(2017) Smruthi Vijayaraghavan et al.   Nature Communications

Protein-Ligand Blind Docking Using QuickVina-W With Inter-Process Spatio-Temporal Integration

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Context-dependent effects of cellular senescence in cancer development

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PEP-FOLD3: fasterde novostructure prediction for linear peptides in solution and in complex

(2016) Alexis Lamiable et al.   NUCLEIC ACIDS RESEARCH

Peptiderive server: derive peptide inhibitors from protein–protein interactions

(2016) Yuval Sedan et al.   NUCLEIC ACIDS RESEARCH

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

DOCK 6: Impact of new features and current docking performance

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I-TASSER server: new development for protein structure and function predictions

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CPPsite 2.0: a repository of experimentally validated cell-penetrating peptides

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Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma

(2015) X. Xie et al.   Cancer Discovery

A d-Amino Acid at the N-Terminus of a Protein Abrogates Its Degradation by the N-End Rule Pathway

(2015) Amy E. Rabideau et al.   ACS Central Science

A d-amino acid containing peptide as a potent, noncovalent inhibitor of α5β1 integrin in human prostate cancer invasion and lung colonization

(2014) Donna M. Veine et al.   CLINICAL & EXPERIMENTAL METASTASIS

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Experimental Validation of the Role of Trifluoroethanol as a Nanocrowder

(2014) Robert M. Culik et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Cellular senescence: from physiology to pathology

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The Hallmarks of Aging

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Programmed Cell Senescence during Mammalian Embryonic Development

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CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

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Vemurafenib Induces Senescence Features in Melanoma Cells

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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B-Raf-Driven Tumors

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Aging, Cellular Senescence, and Cancer

(2012) Judith Campisi   Annual Review of Physiology

Structures of KIX domain of CBP in complex with two FOXO3a transactivation domains reveal promiscuity and plasticity in coactivator recruitment

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Drug-induced Senescence Generates Chemoresistant Stemlike Cells with Low Reactive Oxygen Species

(2011) Santhi Achuthan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

Structure of the human FOXO4-DBD–DNA complex at 1.9 Å resolution reveals new details of FOXO binding to the DNA

(2010) Evzen Boura et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Activation of Forkhead Box O Transcription Factors by Oncogenic BRAF Promotes p21cip1-Dependent Senescence

(2010) P. L. J. de Keizer et al.   CANCER RESEARCH

Pharmacologic Inhibition of Cyclin-Dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts

(2010) K. Michaud et al.   CANCER RESEARCH

Limitations of Peptide Retro-inverso Isomerization in Molecular Mimicry

(2010) Chong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

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Crystal Structure of the p53 Core Domain Bound to a Full Consensus Site as a Self-Assembled Tetramer

(2010) Yongheng Chen et al.   STRUCTURE

BrafV600E cooperates with Pten loss to induce metastatic melanoma

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DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

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Biochemical and Structural Characterization of an Intramolecular Interaction in FOXO3a and Its Binding with p53

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Many roads lead to oncogene-induced senescence

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Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases

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