Post-Translational Modifications of STING: A Potential Therapeutic Target
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Title
Post-Translational Modifications of STING: A Potential Therapeutic Target
Authors
Keywords
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Journal
Frontiers in Immunology
Volume 13, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2022-05-06
DOI
10.3389/fimmu.2022.888147
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Note: Only part of the references are listed.- Discovery of Non-Nucleotide Small-Molecule STING Agonists via Chemotype Hybridization
- (2022) Emily C. Cherney et al. JOURNAL OF MEDICINAL CHEMISTRY
- The cGAS-STING Pathway in Bacterial Infection and Bacterial Immunity
- (2022) Nanxin Liu et al. Frontiers in Immunology
- The transmembrane endoplasmic reticulum–associated E3 ubiquitin ligase TRIM13 restrains the pathogenic-DNA–triggered inflammatory response
- (2022) Xuelian Li et al. Science Advances
- Small-molecule inhibitors targeting small ubiquitin-like modifier pathway for the treatment of cancers and other diseases
- (2022) Dexiang Hua et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Human rhinovirus promotes STING trafficking to replication organelles to promote viral replication
- (2022) Martha Triantafilou et al. Nature Communications
- The clinical impact of glycobiology: targeting selectins, Siglecs and mammalian glycans
- (2021) Benjamin A. H. Smith et al. NATURE REVIEWS DRUG DISCOVERY
- Function and Regulation of Nuclear DNA Sensors During Viral Infection and Tumorigenesis
- (2021) Fan Zhang et al. Frontiers in Immunology
- Protein cysteine palmitoylation in immunity and inflammation
- (2021) Hening Lin FEBS Journal
- Golgi apparatus-synthesized sulfated glycosaminoglycans mediate polymerization and activation of the cGAMP sensor STING
- (2021) Run Fang et al. IMMUNITY
- The tumor suppressor kinase DAPK3 drives tumor-intrinsic immunity through the STING–IFN-β pathway
- (2021) Mariko Takahashi et al. NATURE IMMUNOLOGY
- Pinpointing cysteine oxidation sites by high-resolution proteomics reveals a mechanism of redox-dependent inhibition of human STING
- (2021) Natalia Zamorano Cuervo et al. Science Signaling
- cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE
- (2021) Mona Motwani et al. Frontiers in Immunology
- A diamidobenzimidazole STING agonist protects against SARS-CoV-2 infection
- (2021) Fiachra Humphries et al. Science Immunology
- Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS‐STING Pathway
- (2021) Han Liu et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Inhibition of herpes simplex virus 1 by cepharanthine via promoting cellular autophagy through up-regulation of STING/TBK1/P62 pathway
- (2021) Yao Liu et al. ANTIVIRAL RESEARCH
- cGAS‐STING pathway: post‐translational modifications and functions in sterile inflammatory diseases
- (2021) Ze Hong et al. FEBS Journal
- STING-mediated Syk Signaling Attenuates Tumorigenesis of Colitis‑associated Colorectal Cancer Through Enhancing Intestinal Epithelium Pyroptosis
- (2021) Wenbin Gong et al. INFLAMMATORY BOWEL DISEASES
- Tonic prime-boost of STING signalling mediates Niemann–Pick disease type C
- (2021) Ting-Ting Chu et al. NATURE
- STING inhibitors target the cyclic dinucleotide binding pocket
- (2021) Ze Hong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- STING facilitates nuclear import of herpesvirus genome during infection
- (2021) Yujin Hong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Circulating mitochondrial DNA-triggered autophagy dysfunction via STING underlies sepsis-related acute lung injury
- (2021) Qinjie Liu et al. Cell Death & Disease
- A cell-free assay implicates a role of sphingomyelin and cholesterol in STING phosphorylation
- (2021) Kanoko Takahashi et al. Scientific Reports
- STING Agonists as Cancer Therapeutics
- (2021) Afsaneh Amouzegar et al. Cancers
- The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
- (2021) Zhilei Wang et al. Frontiers in Cell and Developmental Biology
- STING1 Promotes Ferroptosis Through MFN1/2-Dependent Mitochondrial Fusion
- (2021) Changfeng Li et al. Frontiers in Cell and Developmental Biology
- SCD2-mediated monounsaturated fatty acid metabolism regulates cGAS-STING-dependent type I IFN responses in CD4+ T cells
- (2021) Toshio Kanno et al. Communications Biology
- STING inhibitor ameliorates LPS-induced ALI by preventing vascular endothelial cells-mediated immune cells chemotaxis and adhesion
- (2021) Bing Wu et al. ACTA PHARMACOLOGICA SINICA
- STING protects against cardiac dysfunction and remodelling by blocking autophagy
- (2021) Rui Xiong et al. Cell Communication and Signaling
- HIV-1 Vif suppresses antiviral immunity by targeting STING
- (2021) Yu Wang et al. Cellular & Molecular Immunology
- The discovery of potent small molecule cyclic urea activators of STING
- (2021) Sourav Basu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Stimulator of interferon gene (STING) and interferon regulatory factor (IRF) are crucial for shrimp antiviral defense against WSSV infection
- (2021) Piti Amparyup et al. FISH & SHELLFISH IMMUNOLOGY
- Paclitaxel Induces Micronucleation and Activates Pro-Inflammatory cGAS–STING Signaling in Triple-Negative Breast Cancer
- (2021) Yang Hu et al. MOLECULAR CANCER THERAPEUTICS
- The fowl adenovirus serotype 4 (FAdV-4) induce cellular pathway in chickens to produce interferon and antigen-presented molecules (MHCI/II)
- (2021) Meizhen Li et al. POULTRY SCIENCE
- STING-Mediated Interferon Induction by Herpes Simplex Virus 1 Requires the Protein Tyrosine Kinase Syk
- (2021) Chenyao Wang et al. mBio
- The Regulatory Network of Cyclic GMP-AMP Synthase-Stimulator of Interferon Genes Pathway in Viral Evasion
- (2021) Tongyu Hu et al. Frontiers in Microbiology
- Development of Small-Molecule STING Activators for Cancer Immunotherapy
- (2021) Hee Ra Jung et al. Biomedicines
- RNF90 negatively regulates cellular antiviral responses by targeting MITA for degradation
- (2020) Bo Yang et al. PLoS Pathogens
- CSK promotes innate immune response to DNA virus by phosphorylating MITA
- (2020) Peng Gao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection
- (2020) Chiranjeevi Bodda et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Synthetic Immunogenic Cell Death Mediated by Intracellular Delivery of STING Agonist Nanoshells Enhances Anticancer Chemo-immunotherapy
- (2020) Saborni Chattopadhyay et al. NANO LETTERS
- Molecular mechanisms and cellular functions of cGAS–STING signalling
- (2020) Karl-Peter Hopfner et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Small molecules targeting the innate immune cGAS‒STING‒TBK1 signaling pathway
- (2020) Chunyong Ding et al. Acta Pharmaceutica Sinica B
- Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screening
- (2020) Hui Hou et al. BIOORGANIC CHEMISTRY
- Deubiquitinase USP35 restrains STING-mediated interferon signaling in ovarian cancer
- (2020) Jiawen Zhang et al. CELL DEATH AND DIFFERENTIATION
- Old dogs, new trick: classic cancer therapies activate cGAS
- (2020) Seoyun Yum et al. CELL RESEARCH
- Structures and Mechanisms in the cGAS-STING Innate Immunity Pathway
- (2020) Xuewu Zhang et al. IMMUNITY
- cGAS-STING, an important pathway in cancer immunotherapy
- (2020) Minlin Jiang et al. Journal of Hematology & Oncology
- Redox homeostasis maintained by GPX4 facilitates STING activation
- (2020) Mutian Jia et al. NATURE IMMUNOLOGY
- Bacterial-induced cell fusion is a danger signal triggering cGAS–STING pathway via micronuclei formation
- (2020) Joanne Wei Kay Ku et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- PPP6C Negatively Regulates STING-Dependent Innate Immune Responses
- (2020) Guoxin Ni et al. mBio
- Characterization of a Novel Compound That Stimulates STING-Mediated Innate Immune Activity in an Allele-Specific Manner
- (2020) Jinu Abraham et al. Frontiers in Immunology
- OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
- (2020) Yunyun Guo et al. Cellular & Molecular Immunology
- EGFR ‐mediated tyrosine phosphorylation of STING determines its trafficking route and cellular innate immunity functions
- (2020) Chenyao Wang et al. EMBO JOURNAL
- STING cyclic dinucleotide sensing originated in bacteria
- (2020) Benjamin R. Morehouse et al. NATURE
- Global view of human protein glycosylation pathways and functions
- (2020) Katrine T. Schjoldager et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- SUMO: From Bench to Bedside
- (2020) Hui-Ming Chang et al. PHYSIOLOGICAL REVIEWS
- MYSM1 Represses Innate Immunity and Autoimmunity through Suppressing the cGAS-STING Pathway
- (2020) Mingfu Tian et al. Cell Reports
- Reactive oxygen species oxidize STING and suppress interferon production
- (2020) Lili Tao et al. eLife
- When STING Meets Viruses: Sensing, Trafficking and Response
- (2020) Zhaohe Li et al. Frontiers in Immunology
- The discovery of potent small molecule activators of human STING
- (2020) David C. Pryde et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Molecular and spatial mechanisms governing STING signalling
- (2020) Katherine R. Balka et al. FEBS Journal
- Modification of Proteins by Metabolites in Immunity
- (2020) C. Diskin et al. IMMUNITY
- Nanomedicinal delivery of stimulator of interferon genes agonists: recent advances in virus vaccination
- (2020) Saborni Chattopadhyay et al. Nanomedicine
- mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion
- (2020) Xufei Zhang et al. Cell Death & Disease
- STING-dependent induction of lipid peroxidation mediates intestinal ischemia-reperfusion injury
- (2020) Jie Wu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients
- (2020) Marie-Louise Frémond et al. Journal of Allergy and Clinical Immunology-In Practice
- Intracellular bacteria engage a STING–TBK1–MVB12b pathway to enable paracrine cGAS–STING signalling
- (2019) Ramya Nandakumar et al. Nature Microbiology
- Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP
- (2019) Guijun Shang et al. NATURE
- Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
- (2019) Xiang Gui et al. NATURE
- Brucella abortus Cyclic Dinucleotides Trigger STING-Dependent Unfolded Protein Response That Favors Bacterial Replication
- (2019) Erika S. Guimarães et al. JOURNAL OF IMMUNOLOGY
- USP20 Promotes Cellular Antiviral Responses via Deconjugating K48-Linked Ubiquitination of MITA
- (2019) Meng-Xin Zhang et al. JOURNAL OF IMMUNOLOGY
- STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death
- (2019) Jianjun Wu et al. JOURNAL OF EXPERIMENTAL MEDICINE
- STING palmitoylation as a therapeutic target
- (2019) Anne Louise Hansen et al. Cellular & Molecular Immunology
- Discovery and Mechanistic Study of a Novel Human-Stimulator-of-Interferon-Genes Agonist
- (2019) Xiaohui Zhang et al. ACS Infectious Diseases
- STING Polymer Structure Reveals Mechanisms for Activation, Hyperactivation, and Inhibition
- (2019) Sabrina L. Ergun et al. CELL
- Inflammation and Cancer: Triggers, Mechanisms, and Consequences
- (2019) Florian R. Greten et al. IMMUNITY
- DNA sensing by the cGAS–STING pathway in health and disease
- (2019) Mona Motwani et al. NATURE REVIEWS GENETICS
- PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
- (2019) Tian Xia et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Interferon target-gene expression and epigenomic signatures in health and disease
- (2019) Franck J. Barrat et al. NATURE IMMUNOLOGY
- Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists
- (2019) Shi Hou et al. BIOORGANIC CHEMISTRY
- Targeting Stimulator of Interferon Genes (STING): A Medicinal Chemistry Perspective
- (2019) Han Zhang et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design, Synthesis, and Biological Evaluation of Amidobenzimidazole Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists
- (2019) Qiumu Xi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Bisphenol A Activates an Innate Viral Immune Response Pathway
- (2019) Mark L. Sowers et al. JOURNAL OF PROTEOME RESEARCH
- The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer
- (2019) John Kwon et al. Cancer Discovery
- Apoptosis-derived membrane vesicles drive the cGAS–STING pathway and enhance type I IFN production in systemic lupus erythematosus
- (2018) Yasuhiro Kato et al. ANNALS OF THE RHEUMATIC DISEASES
- A novel chemical compound SINCRO with dual function in the STING-type I interferon and tumor cell death pathways
- (2018) Yoshitaka Kimura et al. CANCER SCIENCE
- Targeting pattern-recognition receptors to discover new small molecule immune modulators
- (2018) Gengzheng Zhu et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling
- (2018) Michelle Brault et al. JOURNAL OF IMMUNOLOGY
- Ecology and evolution of Mycobacterium tuberculosis
- (2018) Sebastien Gagneux NATURE REVIEWS MICROBIOLOGY
- UBXN3B positively regulates STING-mediated antiviral immune responses
- (2018) Long Yang et al. Nature Communications
- Analysis of Drosophila STING Reveals an Evolutionarily Conserved Antimicrobial Function
- (2018) Marina Martin et al. Cell Reports
- TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors
- (2018) Brian J. Francica et al. Cancer Immunology Research
- In situ generation, metabolism and immunomodulatory signaling actions of nitro-conjugated linoleic acid in a murine model of inflammation
- (2018) Luis Villacorta et al. Redox Biology
- TRIM29 negatively controls antiviral immune response through targeting STING for degradation
- (2018) Qijie Li et al. Cell Discovery
- Protein palmitoylation and cancer
- (2018) Pin‐Joe Ko et al. EMBO REPORTS
- The Kinase IKKβ Regulates a STING- and NF-κB-Dependent Antiviral Response Pathway in Drosophila
- (2018) Akira Goto et al. IMMUNITY
- Oxidation of cardiac myofilament proteins: Priming for dysfunction?
- (2018) Friederike Cuello et al. MOLECULAR ASPECTS OF MEDICINE
- Targeting STING with covalent small-molecule inhibitors
- (2018) Simone M. Haag et al. NATURE
- Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling
- (2018) Anne Louise Hansen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nuclear cGAS suppresses DNA repair and promotes tumorigenesis
- (2018) Haipeng Liu et al. NATURE
- Design of amidobenzimidazole STING receptor agonists with systemic activity
- (2018) Joshi M. Ramanjulu et al. NATURE
- The Ca2+ sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
- (2018) Sonal Srikanth et al. NATURE IMMUNOLOGY
- Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING
- (2018) Tony Siu et al. ACS Medicinal Chemistry Letters
- The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING
- (2018) Senlin Li et al. Cell Reports
- Roles of glycosaminoglycans as regulators of ligand/receptor complexes
- (2018) Robert G. Smock et al. Open Biology
- Disease-associated mutations identify a novel region in human STING necessary for the control of type I interferon signaling
- (2017) Isabelle Melki et al. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
- p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation
- (2017) Yunfei Chen et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes
- (2017) Silvia Cerboni et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Cytoplasmic chromatin triggers inflammation in senescence and cancer
- (2017) Zhixun Dou et al. NATURE
- Ubiquitylation at the crossroads of development and disease
- (2017) Michael Rape NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Ester alkaloids from Cephalotaxus interfere with the 2’3’-cGAMP-induced type I interferon pathway in vitro
- (2017) Gayoung Park et al. PLoS One
- TRIM29 promotes DNA virus infections by inhibiting innate immune response
- (2017) Junji Xing et al. Nature Communications
- USP13 negatively regulates antiviral responses by deubiquitinating STING
- (2017) He Sun et al. Nature Communications
- Identification of a small molecule that primes the type I interferon response to cytosolic DNA
- (2017) Samira Khiar et al. Scientific Reports
- Opposing roles of Toll-like receptor and cytosolic DNA-STING signaling pathways for Staphylococcus aureus cutaneous host defense
- (2017) Philip O. Scumpia et al. PLoS Pathogens
- Palmitic Acid: Physiological Role, Metabolism and Nutritional Implications
- (2017) Gianfranca Carta et al. Frontiers in Physiology
- STING in tumor and host cells cooperatively work for NK cell-mediated tumor growth retardation
- (2016) Ken Takashima et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
- (2016) Chih-Hang Anthony Tang et al. CANCER RESEARCH
- USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA
- (2016) Man Zhang et al. CELL RESEARCH
- Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus
- (2016) Ming-Ming Hu et al. IMMUNITY
- Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
- (2016) Eileen E. Parkes et al. JNCI-Journal of the National Cancer Institute
- Activation of STING requires palmitoylation at the Golgi
- (2016) Kojiro Mukai et al. Nature Communications
- Activation of STING-Dependent Innate Immune Signaling By S-Phase-Specific DNA Damage in Breast Cancer
- (2016) Eileen E. Parkes et al. JNCI-Journal of the National Cancer Institute
- Innate Immune Pattern Recognition: A Cell Biological Perspective
- (2015) Sky W. Brubaker et al. Annual Review of Immunology
- STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
- (2015) Olivier Demaria et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
- (2015) S. Liu et al. SCIENCE
- TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
- (2015) Yanming Wang et al. PLoS Pathogens
- PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
- (2015) Zexing Li et al. PLoS Pathogens
- The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
- (2014) Qiang Wang et al. IMMUNITY
- STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
- (2014) Seng-Ryong Woo et al. IMMUNITY
- Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways
- (2014) Yinghui Liu et al. JOURNAL OF VIROLOGY
- Post-translational modifications of intermediate filament proteins: mechanisms and functions
- (2014) Natasha T. Snider et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes
- (2014) Kristina A. Archer et al. PLoS Pathogens
- RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms
- (2014) Yue Qin et al. PLoS Pathogens
- Cyclic Dinucleotides Trigger ULK1 (ATG1) Phosphorylation of STING to Prevent Sustained Innate Immune Signaling
- (2013) Hiroyasu Konno et al. CELL
- Cysteine-Mediated Redox Signaling: Chemistry, Biology, and Tools for Discovery
- (2013) Candice E. Paulsen et al. CHEMICAL REVIEWS
- Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology
- (2013) Catharina Steentoft et al. EMBO JOURNAL
- Modulation of Nitro-fatty Acid Signaling
- (2013) Dario A. Vitturi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Ubiquitin Ligases and the Proteasome in Oncogenesis: Novel Targets for Anticancer Therapies
- (2013) Lindsey N. Micel et al. JOURNAL OF CLINICAL ONCOLOGY
- Protein carbonylation and muscle function in COPD and other conditions
- (2013) Esther Barreiro MASS SPECTROMETRY REVIEWS
- Protein carbonylation as a major hallmark of oxidative damage: Update of analytical strategies
- (2013) Maria Fedorova et al. MASS SPECTROMETRY REVIEWS
- STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
- (2013) J. Petrasek et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Ubiquitin System, an Immense Realm
- (2012) Alexander Varshavsky Annual Review of Biochemistry
- TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination
- (2012) Jing Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Cancer-Associated Loss-of-Function Mutations Implicate DAPK3 as a Tumor-Suppressing Kinase
- (2011) J. Brognard et al. CANCER RESEARCH
- The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
- (2010) Tetsuo Tsuchida et al. IMMUNITY
- Post-translational modifications in signal integration
- (2010) Yonathan Lissanu Deribe et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
- (2009) Bo Zhong et al. IMMUNITY
- Pathogenesis, treatment, and prevention of pneumococcal pneumonia
- (2009) Tom van der Poll et al. LANCET
- STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
- (2009) Hiroki Ishikawa et al. NATURE
- The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
- (2008) Bo Zhong et al. IMMUNITY
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
- (2008) Hiroki Ishikawa et al. NATURE
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