STING-mediated Syk Signaling Attenuates Tumorigenesis of Colitis‑associated Colorectal Cancer Through Enhancing Intestinal Epithelium Pyroptosis

CCL4‐mediated targeting of spleen tyrosine kinase (Syk) inhibitor using nanoparticles alleviates inflammatory bowel disease

(2021) Wenbin Gong et al.   Clinical and Translational Medicine

Mincle/Syk Signalling Promotes Intestinal Mucosal Inflammation Through Induction of Macrophage Pyroptosis in Crohn’s Disease

(2020) Wenbin Gong et al.   Journal of Crohns & Colitis

Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation

(2020) Chunmei Ma et al.   Science Advances

Potent STING activation stimulates immunogenic cell death to enhance antitumor immunity in neuroblastoma

(2020) Lihong Wang-Bishop et al.   Journal for ImmunoTherapy of Cancer

Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-based Data

(2019) Stephanie Coward et al.   GASTROENTEROLOGY

Correlation between endoscopic and histological validated scoring indices in Crohn’s disease

(2019) Wenbin Gong et al.   DIGESTIVE AND LIVER DISEASE

Ki-67 protein as a tumour proliferation marker

(2019) Sunil Sankunny Menon et al.   CLINICA CHIMICA ACTA

Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach

(2019) Kanipandian Nagarajan et al.   Translational Oncology

The role of pyroptosis in gastrointestinal cancer and immune responses to intestinal microbial infection

(2019) Cheng-Bei Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

STING: a master regulator in the cancer-immunity cycle

(2019) Yuanyuan Zhu et al.   Molecular Cancer

Pyroptosis: A new frontier in cancer

(2019) Yuan Fang et al.   BIOMEDICINE & PHARMACOTHERAPY

Evolutionary history of human colitis-associated colorectal cancer

(2018) Ann-Marie Baker et al.   GUT

E-cadherin in contact inhibition and cancer

(2018) Alisha M. Mendonsa et al.   ONCOGENE

Is β-Catenin a Druggable Target for Cancer Therapy?

(2018) Can Cui et al.   TRENDS IN BIOCHEMICAL SCIENCES

Genomic characterization of colitis-associated colorectal cancer

(2018) Hitoshi Kameyama et al.   World Journal of Surgical Oncology

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

SYK-CARD9 Signaling Axis Promotes Gut Fungi-Mediated Inflammasome Activation to Restrict Colitis and Colon Cancer

(2018) Ankit Malik et al.   IMMUNITY

ECCO-ESGAR Guideline for Diagnostic Assessment in IBD Part 1: Initial diagnosis, monitoring of known IBD, detections of complications

(2018) Christian Maaser et al.   Journal of Crohns & Colitis

The emerging role of stimulator of interferons genes signaling in sepsis: Inflammation, autophagy, and cell death

(2018) Qiongyuan Hu et al.   Acta Physiologica

Role of the cGAS–STING pathway in cancer development and oncotherapeutic approaches

(2018) Li Teng Khoo et al.   EMBO REPORTS

Genetic and Pharmacological Dissection of the Role of Spleen Tyrosine Kinase (Syk) in Intestinal Inflammation and Immune Dysfunction in Inflammatory Bowel Diseases

(2017) Michele Biagioli et al.   INFLAMMATORY BOWEL DISEASES

The cytosolic sensor STING is required for intestinal homeostasis and control of inflammation

(2017) M C C Canesso et al.   Mucosal Immunology

Cytoplasmic chromatin triggers inflammation in senescence and cancer

(2017) Zhixun Dou et al.   NATURE

Chemically induced mouse models of acute and chronic intestinal inflammation

(2017) Stefan Wirtz et al.   Nature Protocols

STING-Dependent Signaling Underlies IL-10 Controlled Inflammatory Colitis

(2017) Jeonghyun Ahn et al.   Cell Reports

Colorectal Cancer and Dysplasia in Inflammatory Bowel Disease: A Review of Disease Epidemiology, Pathophysiology, and Management

(2016) P. S. Dulai et al.   Cancer Prevention Research

Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells

(2016) Chih-Hang Anthony Tang et al.   CANCER RESEARCH

Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease

(2016) Rona Yaeger et al.   GASTROENTEROLOGY

Cancers Complicating Inflammatory Bowel Disease

(2015) Laurent Beaugerie et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

(2014) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis

(2013) Alexandre Sze et al.   Cell Host & Microbe

The Tyrosine Kinase Syk Differentially Regulates Toll-like Receptor Signaling Downstream of the Adaptor Molecules TRAF6 and TRAF3

(2013) Y.-C. Lin et al.   Science Signaling

Risk Factors for Neoplasia in Inflammatory Bowel Disease Patients With Pancolitis

(2010) Vivianne Bergeron et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE