Interferon target-gene expression and epigenomic signatures in health and disease

Self-Awareness: Nucleic Acid–Driven Inflammation and the Type I Interferonopathies

(2019) Carolina Uggenti et al.   Annual Review of Immunology

Emapalumab: First Global Approval

(2019) Zaina T. Al-Salama   DRUGS

Plasmacytoid Dendritic Cells: Development, Regulation, and Function

(2019) Boris Reizis   IMMUNITY

Chronic TLR7 and TLR9 signaling drives anemia via differentiation of specialized hemophagocytes

(2019) Holly M. Akilesh et al.   SCIENCE

Efficacy of baricitinib in the treatment of chilblains associated with the type I interferonopathy Aicardi-Goutières syndrome

(2019) Kornvalee Meesilpavikkai et al.   Arthritis & Rheumatology

Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice

(2019) Andrew Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the IFNγ receptor complex guides design of biased agonists

(2019) Juan L. Mendoza et al.   NATURE

A defined commensal consortium elicits CD8 T cells and anti-cancer immunity

(2019) Takeshi Tanoue et al.   NATURE

Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus

(2019) Richard Furie et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole-genome sequencing identifies complex contributions to genetic risk by variants in genes causing monogenic systemic lupus erythematosus

(2019) Jonas Carlsson Almlöf et al.   HUMAN GENETICS

Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry

(2019) Fan Zhang et al.   NATURE IMMUNOLOGY

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways

(2019) Evan Der et al.   NATURE IMMUNOLOGY

HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness

(2019) David Kuo et al.   Science Translational Medicine

The immune cell landscape in kidneys of patients with lupus nephritis

(2019) Arnon Arazi et al.   NATURE IMMUNOLOGY

Photosensitivity and type I IFN responses in cutaneous lupus are driven by epidermal-derived interferon kappa

(2018) Mrinal K Sarkar et al.   ANNALS OF THE RHEUMATIC DISEASES

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

(2018) Leandro Ladislau et al.   BRAIN

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

JAK1/2 inhibition with baricitinib in the treatment of autoinflammatory interferonopathies

(2018) Gina A. Montealegre Sanchez et al.   JOURNAL OF CLINICAL INVESTIGATION

Baricitinib for systemic lupus erythematosus: a double-blind, randomised, placebo-controlled, phase 2 trial

(2018) Daniel J Wallace et al.   LANCET

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

(2018) Marie Dominique Ah Kioon et al.   Science Translational Medicine

Identification of Three Rheumatoid Arthritis Disease Subtypes by Machine Learning Integration of Synovial Histologic Features and RNA Sequencing Data

(2018) Dana E. Orange et al.   Arthritis & Rheumatology

Induction of innate immune memory via microRNA targeting of chromatin remodelling factors

(2018) John J. Seeley et al.   NATURE

Mitochondrial double-stranded RNA triggers antiviral signalling in humans

(2018) Ashish Dhir et al.   NATURE

Interferon stimulation creates chromatin marks and establishes transcriptional memory

(2018) Rui Kamada et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 9 activation potentiates interferon-γ-mediated immunopathology in a murine model of Macrophage Activation Syndrome

(2018) Lehn K. Weaver et al.   Arthritis & Rheumatology

Efficacy of JAK1/2 inhibition in the treatment of chilblain lupus due to TREX1 deficiency

(2018) Coralie Briand et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of Autonomous Memory Alveolar Macrophages Requires T Cell Help and Is Critical to Trained Immunity

(2018) Yushi Yao et al.   CELL

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

(2018) Bence Daniel et al.   IMMUNITY

Reverse-Transcriptase Inhibitors in the Aicardi–Goutières Syndrome

(2018) Gillian I. Rice et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of alterations in macrophage activation associated with disease activity in systemic lupus erythematosus

(2018) Adam C. Labonte et al.   PLoS One

Commensal-specific T cell plasticity promotes rapid tissue adaptation to injury

(2018) Oliver J. Harrison et al.   SCIENCE

Type I Interferons in Autoimmune Disease

(2018) Mary K. Crow et al.   Annual Review of Pathology-Mechanisms of Disease

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF

(2017) Kyuho Kang et al.   IMMUNITY

Detection of interferon alpha protein reveals differential levels and cellular sources in disease

(2017) Mathieu P. Rodero et al.   JOURNAL OF EXPERIMENTAL MEDICINE

dNK derived IFN-γ mediates VSMC migration and apoptosis via the induction of LncRNA MEG3: A role in uterovascular transformation

(2017) Weifang Liu et al.   PLACENTA

Transancestral mapping and genetic load in systemic lupus erythematosus

(2017) Carl D. Langefeld et al.   Nature Communications

Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus

(2017) Richard Furie et al.   Arthritis & Rheumatology

Altered type II interferon precedes autoantibody accrual and elevated type I interferon activity prior to systemic lupus erythematosus classification

(2016) Melissa E Munroe et al.   ANNALS OF THE RHEUMATIC DISEASES

Elevated circulating levels of interferon-γ and interferon-γ-induced chemokines characterise patients with macrophage activation syndrome complicating systemic juvenile idiopathic arthritis

(2016) Claudia Bracaglia et al.   ANNALS OF THE RHEUMATIC DISEASES

Importance of Nucleic Acid Recognition in Inflammation and Autoimmunity

(2016) Franck J. Barrat et al.   Annual Review of Medicine

Alpha and Beta Type 1 Interferon Signaling: Passage for Diverse Biologic Outcomes

(2016) Cherie T. Ng et al.   CELL

Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity

(2016) Vanja Sisirak et al.   CELL

Parsing the Interferon Transcriptional Network and Its Disease Associations

(2016) Sara Mostafavi et al.   CELL

Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

(2016) Romain Banchereau et al.   CELL

Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus

(2016) Simone Caielli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus

(2016) Hanna Kim et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour

(2016) Anthony J. Filiano et al.   NATURE

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Perspective: Targeting the JAK/STAT pathway to fight age-related dysfunction

(2016) Ming Xu et al.   PHARMACOLOGICAL RESEARCH

Trained immunity: A program of innate immune memory in health and disease

(2016) M. G. Netea et al.   SCIENCE

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages

(2016) Yu Qiao et al.   Cell Reports

Expression of Long Interspersed Nuclear Element 1 Retroelements and Induction of Type I Interferon in Patients With Systemic Autoimmune Disease

(2016) Clio P. Mavragani et al.   Arthritis & Rheumatology

Pathogenesis of Macrophage Activation Syndrome and Potential for Cytokine- Directed Therapies

(2015) Grant S. Schulert et al.   Annual Review of Medicine

Interferon regulatory factor 1 and histone H4 acetylation in systemic lupus erythematosus

(2015) Yiu Tak Leung et al.   Epigenetics

Superiority of Transcriptional Profiling Over Procalcitonin for Distinguishing Bacterial From Viral Lower Respiratory Tract Infections in Hospitalized Adults

(2015) Nicolas M. Suarez et al.   JOURNAL OF INFECTIOUS DISEASES

Guarding the frontiers: the biology of type III interferons

(2015) Andreas Wack et al.   NATURE IMMUNOLOGY

Innate immune recognition of DNA: A recent history

(2015) Alan Dempsey et al.   VIROLOGY

Blockade of Interferon-γ Normalizes Interferon-Regulated Gene Expression and Serum CXCL10 Levels in Patients With Systemic Lupus Erythematosus

(2015) Andrew A. Welcher et al.   Arthritis & Rheumatology

A Longitudinal Biomarker for the Extent of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis

(2015) Lisa M. Rice et al.   Arthritis & Rheumatology

No Love Lost Between Viruses and Interferons

(2015) Volker Fensterl et al.   Annual Review of Virology

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis

(2014) D L Boyle et al.   ANNALS OF THE RHEUMATIC DISEASES

Chromatin Contributions to the Regulation of Innate Immunity

(2014) Stephen T. Smale et al.   Annual Review of Immunology

Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

(2014) Nadia Jeremiah et al.   JOURNAL OF CLINICAL INVESTIGATION

Early, transient depletion of plasmacytoid dendritic cells ameliorates autoimmunity in a lupus model

(2014) Sarah L. Rowland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Genetic evidence for the role of plasmacytoid dendritic cells in systemic lupus erythematosus

(2014) Vanja Sisirak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses

(2014) A. Forsbach et al.   JOURNAL OF IMMUNOLOGY

Activated STING in a Vascular and Pulmonary Syndrome

(2014) Yin Liu et al.   NEW ENGLAND JOURNAL OF MEDICINE

The SLE Transcriptome Exhibits Evidence of Chronic Endotoxin Exposure and Has Widespread Dysregulation of Non-Coding and Coding RNAs

(2014) Lihua Shi et al.   PLoS One

Modular Transcriptional Repertoire Analyses of Adults With Systemic Lupus Erythematosus Reveal Distinct Type I and Type II Interferon Signatures

(2014) Laurent Chiche et al.   Arthritis & Rheumatology

Editorial: Interferon-γ: Friend or Foe in Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still's Disease?

(2014) Scott W. Canna   Arthritis & Rheumatology

Latent Enhancers Activated by Stimulation in Differentiated Cells

(2013) Renato Ostuni et al.   CELL

Synergistic Activation of Inflammatory Cytokine Genes by Interferon-γ-Induced Chromatin Remodeling and Toll-like Receptor Signaling

(2013) Yu Qiao et al.   IMMUNITY

Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing

(2013) Nadine Gehrke et al.   IMMUNITY

RNA recognition by human TLR8 can lead to autoimmune inflammation

(2013) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Identification of novel oligonucleotides from mitochondrial DNA that spontaneously induce plasmacytoid dendritic cell activation

(2013) Moritz Ries et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma

(2013) Elizabeth E. Gerber et al.   NATURE

Short-term memory of danger signals and environmental stimuli in immune cells

(2013) Silvia Monticelli et al.   NATURE IMMUNOLOGY

Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis

(2013) Lenny van Bon et al.   NEW ENGLAND JOURNAL OF MEDICINE

Commensal Bacteria Calibrate the Activation Threshold of Innate Antiviral Immunity

(2012) Michael C. Abt et al.   IMMUNITY

Constitutive Type I Interferon Modulates Homeostatic Balance through Tonic Signaling

(2012) Daniel J. Gough et al.   IMMUNITY

Priming of Natural Killer Cells by Nonmucosal Mononuclear Phagocytes Requires Instructive Signals from Commensal Microbiota

(2012) Stephanie C. Ganal et al.   IMMUNITY

The JAK-STAT Pathway at Twenty

(2012) George R. Stark et al.   IMMUNITY

INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

(2012) Irina Rusinova et al.   NUCLEIC ACIDS RESEARCH

Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases

(2012) J. C. Hall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Type I interferonopathies: a novel set of inborn errors of immunity

(2011) Yanick J. Crow   Annals of the New York Academy of Sciences

Mutations in proteasome subunit β type 8 cause chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature with evidence of genetic and phenotypic heterogeneity

(2011) Yin Liu et al.   ARTHRITIS AND RHEUMATISM

Structural Linkage between Ligand Discrimination and Receptor Activation by Type I Interferons

(2011) Christoph Thomas et al.   CELL

T Lymphocytes Negatively Regulate Lymph Node Lymphatic Vessel Formation

(2011) Raghu P. Kataru et al.   IMMUNITY

Toll-like Receptors and Their Crosstalk with Other Innate Receptors in Infection and Immunity

(2011) Taro Kawai et al.   IMMUNITY

Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9

(2010) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons

(2010) Josh Gregorio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IFN-  abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling

(2010) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

(2010) A. Triantafyllopoulou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

(2009) Xiaoyu Hu et al.   IMMUNOLOGICAL REVIEWS

Selective and direct activation of human neutrophils but not eosinophils by Toll-like receptor 8

(2009) Markus Janke et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Endotoxin tolerance: new mechanisms, molecules and clinical significance

(2009) Subhra K. Biswas et al.   TRENDS IN IMMUNOLOGY

Association of the IRF5 risk haplotype with high serum interferon-α activity in systemic lupus erythematosus patients

(2008) Timothy B. Niewold et al.   ARTHRITIS AND RHEUMATISM

Trex1 Prevents Cell-Intrinsic Initiation of Autoimmunity

(2008) Daniel B. Stetson et al.   CELL

PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation

(2008) Cristiana Guiducci et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications

(2008) C. Guiducci et al.   JOURNAL OF INTERNAL MEDICINE

An IFN-Associated Cytotoxic Cellular Immune Response against Viral, Self-, or Tumor Antigens Is a Common Pathogenetic Feature in “Interface Dermatitis”

(2008) Joerg Wenzel et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY