p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation

The cGAS-STING Defense Pathway and Its Counteraction by Viruses

(2016) Zhe Ma et al.   Cell Host & Microbe

NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses

(2016) Haitao Guo et al.   Cell Host & Microbe

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

(2016) Man Zhang et al.   CELL RESEARCH

The Type I Interferon-IRF7 Axis Mediates Transcriptional Expression ofUsp25Gene

(2016) Yujie Ren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The centrosomal Deubiquitylase USP21 regulates Gli1 transcriptional activity and stability.

(2016) Claire Heride et al.   JOURNAL OF CELL SCIENCE

iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING

(2016) Wei-Wei Luo et al.   NATURE IMMUNOLOGY

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

(2016) Jiali Jin et al.   Nature Communications

The 11S Proteasome Subunit PSME3 Is a Positive Feedforward Regulator of NF-κB and Important for Host Defense against Bacterial Pathogens

(2016) Jinxia Sun et al.   Cell Reports

Regulation of maintenance DNA methylation via histone ubiquitylation

(2015) Atsuya Nishiyama et al.   JOURNAL OF BIOCHEMISTRY

The Ubiquitination of RagA GTPase by RNF152 Negatively Regulates mTORC1 Activation

(2015) Lu Deng et al.   MOLECULAR CELL

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

(2015) S. Liu et al.   SCIENCE

The STING pathway and the T cell-inflamed tumor microenvironment

(2015) Seng-Ryong Woo et al.   TRENDS IN IMMUNOLOGY

TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

(2015) Yanming Wang et al.   PLoS Pathogens

Innate Immune Sensing and Signaling of Cytosolic Nucleic Acids

(2014) Jiaxi Wu et al.   Annual Review of Immunology

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

Adding to the STING

(2014) Hong-Bing Shu et al.   IMMUNITY

NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING

(2014) Lu Zhang et al.   IMMUNITY

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

(2014) Yihui Fan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

STING-Dependent Type I IFN Production Inhibits Cell-Mediated Immunity to Listeria monocytogenes

(2014) Kristina A. Archer et al.   PLoS Pathogens

RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms

(2014) Yue Qin et al.   PLoS Pathogens

Identification of the E3 Deubiquitinase Ubiquitin-specific Peptidase 21 (USP21) as a Positive Regulator of the Transcription Factor GATA3

(2013) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

A Strategy for Modulation of Enzymes in the Ubiquitin System

(2013) A. Ernst et al.   SCIENCE

TRIM32 Protein Modulates Type I Interferon Induction and Cellular Antiviral Response by Targeting MITA/STING Protein for K63-linked Ubiquitination

(2012) Jing Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions

(2012) Sylvie Urbé et al.   MOLECULAR BIOLOGY OF THE CELL

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

A global survey of CRM1-dependent nuclear export sequences in the human deubiquitinase family

(2011) Iraia García-Santisteban et al.   BIOCHEMICAL JOURNAL

Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21

(2011) Yu Ye et al.   EMBO REPORTS

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

(2011) Zhiqiang Zhang et al.   NATURE IMMUNOLOGY

The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA

(2010) Tetsuo Tsuchida et al.   IMMUNITY

The Fbw7/Human CDC4 Tumor Suppressor Targets Proproliferative Factor KLF5 for Ubiquitination and Degradation through Multiple Phosphodegron Motifs

(2010) Ning Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IFI16 is an innate immune sensor for intracellular DNA

(2010) Leonie Unterholzner et al.   NATURE IMMUNOLOGY

The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA

(2009) Bo Zhong et al.   IMMUNITY

Ubiquitin-specific Peptidase 21 Inhibits Tumor Necrosis Factor α-induced Nuclear Factor κB Activation via Binding to and Deubiquitinating Receptor-interacting Protein 1

(2009) Gufeng Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation in innate and adaptive immunity

(2009) Vijay G. Bhoj et al.   NATURE

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

(2009) Hiroki Ishikawa et al.   NATURE

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

(2009) T. Saitoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization

(2009) W. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Detection of Protein Ubiquitination

(2009) Yeun Su Choo et al.   Jove-Journal of Visualized Experiments

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

Suppression of p38 mitogen-activated protein kinase inhibits hepatitis B virus replication in human hepatoma cell: the antiviral role of nitric oxide

(2008) W.-W. Chang et al.   JOURNAL OF VIRAL HEPATITIS

MPYS, a Novel Membrane Tetraspanner, Is Associated with Major Histocompatibility Complex Class II and Mediates Transduction of Apoptotic Signals

(2008) L. Jin et al.   MOLECULAR AND CELLULAR BIOLOGY