Ubiquitylation at the crossroads of development and disease

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination

(2017) Szymon Juszkiewicz et al.   MOLECULAR CELL

ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation

(2017) Elayanambi Sundaramoorthy et al.   MOLECULAR CELL

Translation from unconventional 5′ start sites drives tumour initiation

(2017) Ataman Sendoel et al.   NATURE

Whole-genome landscapes of major melanoma subtypes

(2017) Nicholas K. Hayward et al.   NATURE

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15

(2017) Ting Han et al.   SCIENCE

CRL4 DCAF8 Ubiquitin Ligase Targets Histone H3K79 and Promotes H3K9 Methylation in the Liver

(2017) Gaofeng Li et al.   Cell Reports

Phosphoribosylation of Ubiquitin Promotes Serine Ubiquitination and Impairs Conventional Ubiquitination

(2016) Sagar Bhogaraju et al.   CELL

Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor

(2016) Colleen A. McGourty et al.   CELL

SCF (Fbxl17) ubiquitylation of Sufu regulates Hedgehog signaling and medulloblastoma development

(2016) Madalina Raducu et al.   EMBO JOURNAL

The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1E3 ligase

(2016) Beezly S Groh et al.   EMBO REPORTS

Trim9 Deletion Alters the Morphogenesis of Developing and Adult-Born Hippocampal Neurons and Impairs Spatial Learning and Memory

(2016) Cortney C. Winkle et al.   JOURNAL OF NEUROSCIENCE

MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

(2016) Syed Arif Abdul Rehman et al.   MOLECULAR CELL

Glutamine Triggers Acetylation-Dependent Degradation of Glutamine Synthetase via the Thalidomide Receptor Cereblon

(2016) Thang Van Nguyen et al.   MOLECULAR CELL

CRL4 WDR23 -Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication

(2016) Mia M.L. Brodersen et al.   MOLECULAR CELL

A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

(2016) Mary E. Matyskiela et al.   NATURE

Stem cell function and stress response are controlled by protein synthesis

(2016) Sandra Blanco et al.   NATURE

The RSPO–LGR4/5–ZNRF3/RNF43 module controls liver zonation and size

(2016) Lara Planas-Paz et al.   NATURE CELL BIOLOGY

The increasing complexity of the ubiquitin code

(2016) Richard Yau et al.   NATURE CELL BIOLOGY

Mutations in the HECT domain of NEDD4L lead to AKT–mTOR pathway deregulation and cause periventricular nodular heterotopia

(2016) Loïc Broix et al.   NATURE GENETICS

The ubiquitin ligase Huwe1 regulates the maintenance and lymphoid commitment of hematopoietic stem cells

(2016) Bryan King et al.   NATURE IMMUNOLOGY

Angelman syndrome — insights into a rare neurogenetic disorder

(2016) Karin Buiting et al.   Nature Reviews Neurology

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds

(2016) Babita Madan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog-dependent E3-ligase Midline1 regulates ubiquitin-mediated proteasomal degradation of Pax6 during visual system development

(2016) Thorsten Pfirrmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Return to quiescence of mouse neural stem cells by degradation of a proactivation protein

(2016) Noelia Urbán et al.   SCIENCE

Ubiquitin-Dependent And Independent Signals In Selective Autophagy

(2016) Aliaksandr Khaminets et al.   TRENDS IN CELL BIOLOGY

Role of frameshift ubiquitin B protein in Alzheimer's disease

(2016) Xin Chen et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

(2016) Jiali Jin et al.   Nature Communications

Ribosome-associated protein quality control

(2016) Onn Brandman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deubiquitinase MYSM1 Is Essential for Normal Bone Formation and Mesenchymal Stem Cell Differentiation

(2016) Ping Li et al.   Scientific Reports

HUWE1 mutations in Juberg-Marsidi and Brooks syndromes: the results of an X-chromosome exome sequencing study

(2016) Michael J Friez et al.   BMJ Open

Smurf1 Inhibits Osteoblast Differentiation, Bone Formation, and Glucose Homeostasis through Serine 148

(2016) Junko Shimazu et al.   Cell Reports

An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A

(2015) Jason J. Yi et al.   CELL

The E3 Ubiquitin Ligase TRIM9 Is a Filopodia Off Switch Required for Netrin-Dependent Axon Guidance

(2015) Shalini Menon et al.   DEVELOPMENTAL CELL

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

De novodominantASXL3mutations alter H2A deubiquitination and transcription in Bainbridge–Ropers syndrome

(2015) Anshika Srivastava et al.   HUMAN MOLECULAR GENETICS

The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins

(2015) Reneé Higgins et al.   MOLECULAR CELL

Dishevelled Promotes Wnt Receptor Degradation through Recruitment of ZNRF3/RNF43 E3 Ubiquitin Ligases

(2015) Xiaomo Jiang et al.   MOLECULAR CELL

Structure and Assembly Pathway of the Ribosome Quality Control Complex

(2015) Sichen Shao et al.   MOLECULAR CELL

A Tail of Two Sites: A Bipartite Mechanism for Recognition of Notch Ligands by Mind Bomb E3 Ligases

(2015) Brian J. McMillan et al.   MOLECULAR CELL

eIF3 targets cell-proliferation messenger RNAs for translational activation or repression

(2015) Amy S. Y. Lee et al.   NATURE

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

(2015) Jan Krönke et al.   NATURE

Cell-fate determination by ubiquitin-dependent regulation of translation

(2015) Achim Werner et al.   NATURE

Spatiotemporal regulation of the anaphase-promoting complex in mitosis

(2015) Sushama Sivakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain

(2015) Ju Huang et al.   NEURON

Spatiotemporal 16p11.2 Protein Network Implicates Cortical Late Mid-Fetal Brain Development and KCTD13-Cul3-RhoA Pathway in Psychiatric Diseases

(2015) Guan Ning Lin et al.   NEURON

The histone H2A deubiquitinase Usp16 regulates hematopoiesis and hematopoietic stem cell function

(2015) Yue Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phthalimide conjugation as a strategy for in vivo target protein degradation

(2015) G. E. Winter et al.   SCIENCE

Layers of DUB regulation

(2015) Danny D. Sahtoe et al.   TRENDS IN BIOCHEMICAL SCIENCES

Coupled local translation and degradation regulate growth cone collapse

(2015) Alessia Deglincerti et al.   Nature Communications

K63 polyubiquitination is a new modulator of the oxidative stress response

(2015) Gustavo M Silva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Enhanced Protein Degradation by Branched Ubiquitin Chains

(2014) Hermann-Josef Meyer et al.   CELL

Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells

(2014) Rocio Sancho et al.   Cell Stem Cell

Shh Signaling Protects Atoh1 from Degradation Mediated by the E3 Ubiquitin Ligase Huwe1 in Neural Precursors

(2014) Antoine Forget et al.   DEVELOPMENTAL CELL

Ubiquitin acetylation inhibits polyubiquitin chain elongation

(2014) F. Ohtake et al.   EMBO REPORTS

Limiting the power of p53 through the ubiquitin proteasome pathway

(2014) Vinod Pant et al.   GENES & DEVELOPMENT

PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity

(2014) Lesley A. Kane et al.   JOURNAL OF CELL BIOLOGY

BRCA1 Promotes Unloading of the CMG Helicase from a Stalled DNA Replication Fork

(2014) David T. Long et al.   MOLECULAR CELL

Synaptic, transcriptional and chromatin genes disrupted in autism

(2014) Silvia De Rubeis et al.   NATURE

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Haematopoietic stem cells require a highly regulated protein synthesis rate

(2014) Robert A. J. Signer et al.   NATURE

Biological insights from 108 schizophrenia-associated genetic loci

(2014)   NATURE

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

(2014) Reinhard Kalb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control

(2014) H. Clevers et al.   SCIENCE

Tyrosine phosphorylation of NEDD4 activates its ubiquitin ligase activity

(2014) A. Persaud et al.   Science Signaling

Disruption of polyubiquitin gene Ubb causes dysregulation of neural stem cell differentiation with premature gliogenesis

(2014) Han-Wook Ryu et al.   Scientific Reports

A Cul4 E3 Ubiquitin Ligase Regulates Histone Hand-Off during Nucleosome Assembly

(2013) Junhong Han et al.   CELL

Threshold-controlled ubiquitination of the EGFR directs receptor fate

(2013) Sara Sigismund et al.   EMBO JOURNAL

Altered Social Behavior and Neuronal Development in Mice Lacking the Uba6-Use1 Ubiquitin Transfer System

(2013) Peter C.W. Lee et al.   MOLECULAR CELL

A Cotranslational Ubiquitination Pathway for Quality Control of Misfolded Proteins

(2013) Feng Wang et al.   MOLECULAR CELL

Fbxl10/Kdm2b Recruits Polycomb Repressive Complex 1 to CpG Islands and Regulates H2A Ubiquitylation

(2013) Xudong Wu et al.   MOLECULAR CELL

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy

(2013) Guillermo Luxán et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mysterious Ribosomopathies

(2013) K. L. McCann et al.   SCIENCE

The Myeloma Drug Lenalidomide Promotes the Cereblon-Dependent Destruction of Ikaros Proteins

(2013) G. Lu et al.   SCIENCE

The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors

(2013) Manuel Eguren et al.   Nature Communications

APC/C-Cdh1 coordinates neurogenesis and cortical size during development

(2013) Maria Delgado-Esteban et al.   Nature Communications

Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome

(2013) Rati Verma et al.   eLife

A Ribosome-Bound Quality Control Complex Triggers Degradation of Nascent Peptides and Signals Translation Stress

(2012) Onn Brandman et al.   CELL

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

Regulation of Pluripotency and Cellular Reprogramming by the Ubiquitin-Proteasome System

(2012) Shannon M. Buckley et al.   Cell Stem Cell

The E3 ligase Cdh1-anaphase promoting complex operates upstream of the E3 ligase Smurf1 in the control of axon growth

(2012) M. Kannan et al.   DEVELOPMENT

PCGF Homologs, CBX Proteins, and RYBP Define Functionally Distinct PRC1 Family Complexes

(2012) Zhonghua Gao et al.   MOLECULAR CELL

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Increased proteasome activity in human embryonic stem cells is regulated by PSMD11

(2012) David Vilchez et al.   NATURE

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

(2012) Huai-Xiang Hao et al.   NATURE

Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors

(2012) Bon-Kyoung Koo et al.   NATURE

Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations

(2012) Brian J. O’Roak et al.   NATURE

A tumor suppressor function of Smurf2 associated with controlling chromatin landscape and genome stability through RNF20

(2012) Michael Blank et al.   NATURE MEDICINE

Perturbation of the Hematopoietic System during Embryonic Liver Development Due to Disruption of Polyubiquitin Gene Ubc in Mice

(2012) Kwon-Yul Ryu et al.   PLoS One

Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation

(2012) A. Dey et al.   SCIENCE

Kinetic Responses of  -Catenin Specify the Sites of Wnt Control

(2012) A. R. Hernandez et al.   SCIENCE

What is bad in cancer is good in the embryo: Importance of EMT in neural crest development

(2012) Laura Kerosuo et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Histone H2A Mono-Ubiquitination Is a Crucial Step to Mediate PRC1-Dependent Repression of Developmental Genes to Maintain ES Cell Identity

(2012) Mitsuhiro Endoh et al.   PLoS Genetics

Role of the ubiquitin ligase Fbw7 in cancer progression

(2011) Yabin Cheng et al.   CANCER AND METASTASIS REVIEWS

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

(2011) Avinash Persaud et al.   EMBO JOURNAL

Control of B Cell Development by the Histone H2A Deubiquitinase MYSM1

(2011) Xiao-Xia Jiang et al.   IMMUNITY

The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1

(2011) Rachel Lander et al.   JOURNAL OF CELL BIOLOGY

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas

(2011) Shanshan Duan et al.   NATURE

Notch in the Vertebrate Nervous System: An Old Dog with New Tricks

(2011) Tarran Pierfelice et al.   NEURON

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Assembling Neural Crest Regulatory Circuits into a Gene Regulatory Network

(2010) Paola Betancur et al.   Annual Review of Cell and Developmental Biology

The Fused/Smurf Complex Controls the Fate of Drosophila Germline Stem Cells by Generating a Gradient BMP Response

(2010) Laixin Xia et al.   CELL

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB

(2010) Johanna C. Scheuermann et al.   NATURE

Role of a ribosome-associated E3 ubiquitin ligase in protein quality control

(2010) Mario H. Bengtson et al.   NATURE

The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid

(2010) Weiguo Zou et al.   NATURE CELL BIOLOGY

Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase–substrate complex

(2010) Linsey Reavie et al.   NATURE IMMUNOLOGY

APC/CFzr/Cdh1-dependent regulation of cell adhesion controls glial migration in the Drosophila PNS

(2010) Marion Silies et al.   NATURE NEUROSCIENCE

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

(2010) Janel O. Johnson et al.   NEURON

Glutamine Deamidation and Dysfunction of Ubiquitin/NEDD8 Induced by a Bacterial Effector Family

(2010) J. Cui et al.   SCIENCE

Identification of a Primary Target of Thalidomide Teratogenicity

(2010) T. Ito et al.   SCIENCE

Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity

(2009) H. C. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

(2009) Masashi Sanada et al.   NATURE

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

(2009) Brenda A. Schulman et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration

(2009) J. Chu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Cdc20-APC Ubiquitin Signaling Pathway Regulates Presynaptic Differentiation

(2009) Y. Yang et al.   SCIENCE

Disease-Associated Mutant Ubiquitin Causes Proteasomal Impairment and Enhances the Toxicity of Protein Aggregates

(2009) Elizabeth M. H. Tank et al.   PLoS Genetics

Rare Missense and Synonymous Variants in UBE1 Are Associated with X-Linked Infantile Spinal Muscular Atrophy

(2008) Juliane Ramser et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mechanism of Ubiquitin-Chain Formation by the Human Anaphase-Promoting Complex

(2008) Lingyan Jin et al.   CELL

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin

(2008) David F. Fischer et al.   NEUROBIOLOGY OF AGING

Hypothalamic neurodegeneration and adult-onset obesity in mice lacking the Ubb polyubiquitin gene

(2008) K.-Y. Ryu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

(2008) L. J. Reid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

E1 Ubiquitin-Activating Enzyme UBA-1 Plays Multiple Roles throughout C. elegans Development

(2008) Madhura Kulkarni et al.   PLoS Genetics