Post-translational modifications of intermediate filament proteins: mechanisms and functions

Sumoylation: A Regulatory Protein Modification in Health and Disease

(2013) Annette Flotho et al.   Annual Review of Biochemistry

When Lamins Go Bad: Nuclear Structure and Disease

(2013) Katherine H. Schreiber et al.   CELL

Networking galore: intermediate filaments and cell migration

(2013) Byung-Min Chung et al.   CURRENT OPINION IN CELL BIOLOGY

Posttranslational modifications of desmin and their implication in biological processes and pathologies

(2013) Daniel L. Winter et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Topographic regulation of neuronal intermediate filaments by phosphorylation, role of peptidyl-prolyl isomerase 1: significance in neurodegeneration

(2013) B. K. Binukumar et al.   HISTOCHEMISTRY AND CELL BIOLOGY

A Conserved Rod Domain Phosphotyrosine That Is Targeted by the Phosphatase PTP1B Promotes Keratin 8 Protein Insolubility and Filament Organization

(2013) Natasha T. Snider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratin 8 and 18 Loss in Epithelial Cancer Cells Increases Collective Cell Migration and Cisplatin Sensitivity through Claudin1 Up-regulation

(2013) Anne-Marie Fortier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation

(2013) Natasha T. Snider et al.   JOURNAL OF CELL BIOLOGY

Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome

(2013) Michael Bremang et al.   Molecular BioSystems

A General Molecular Affinity Strategy for Global Detection and Proteomic Analysis of Lysine Methylation

(2013) Kaitlyn E. Moore et al.   MOLECULAR CELL

A Method for Systematic Mapping of Protein Lysine Methylation Identifies Functions for HP1β in DNA Damage Response

(2013) Huadong Liu et al.   MOLECULAR CELL

Transglutaminase and Polyamination of Tubulin: Posttranslational Modification for Stabilizing Axonal Microtubules

(2013) Yuyu Song et al.   NEURON

Understanding the Role of Keratins 8 and 18 in Neoplastic Potential of Breast Cancer Derived Cell Lines

(2013) Sapna V. Iyer et al.   PLoS One

Keratins significantly contribute to cell stiffness and impact invasive behavior

(2013) K. Seltmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration

(2013) H.-J. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

14-3-3  stabilizes a complex of soluble actin and intermediate filament to enable breast tumor invasion

(2013) A. Boudreau et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Protein Prenylation in Progeria

(2013) S. G. Young et al.   Science Translational Medicine

Disruption of lamin B1 and lamin B2 processing and localization by farnesyltransferase inhibitors

(2013) Stephen A. Adam et al.   Nucleus

Inhibition of extracellular signal-regulated kinase 1/2 signaling has beneficial effects on skeletal muscle in a mouse model of Emery-Dreifuss muscular dystrophy caused by lamin A/C gene mutation

(2013) Antoine Muchir et al.   Skeletal Muscle

O-GlcNAcase is essential for embryonic development and maintenance of genomic stability

(2012) Yong Ryoul Yang et al.   AGING CELL

Nuclear Envelope Budding Enables Large Ribonucleoprotein Particle Export during Synaptic Wnt Signaling

(2012) Sean D. Speese et al.   CELL

Keratins

(2012) Pavel Strnad et al.   CURRENT OPINION IN GASTROENTEROLOGY

Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory-Denk body formation

(2012) Raymond Kwan et al.   FASEB JOURNAL

Vimentin phosphorylation by Cdc2 in Schwann cell controls axon growth via β1-integrin activation

(2012) In Ae Chang et al.   FASEB JOURNAL

Effects of keratin phosphorylation on the mechanical properties of keratin filaments in living cells

(2012) Giorgio Fois et al.   FASEB JOURNAL

Molecular and Biological Characterization of Streptococcal SpyA-mediated ADP-ribosylation of Intermediate Filament Protein Vimentin

(2012) Laura M. Icenogle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progeria: Translational insights from cell biology

(2012) Leslie B. Gordon et al.   JOURNAL OF CELL BIOLOGY

A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair

(2012) Jeremy D. Rotty et al.   JOURNAL OF CELL BIOLOGY

Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy

(2012) Shenhav Cohen et al.   JOURNAL OF CELL BIOLOGY

Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells

(2012) T. Busch et al.   JOURNAL OF CELL SCIENCE

Lamins at a glance

(2012) C. Y. Ho et al.   JOURNAL OF CELL SCIENCE

Neurofilaments at a glance

(2012) A. Yuan et al.   JOURNAL OF CELL SCIENCE

Keratins Mediate Localization of Hemidesmosomes and Repress Cell Motility

(2012) Kristin Seltmann et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Neurofilament phosphorylation and their proline-directed kinases in health and disease

(2012) Anne Holmgren et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Lamin A tail modification by SUMO1 is disrupted by familial partial lipodystrophy–causing mutations

(2012) Dan N. Simon et al.   MOLECULAR BIOLOGY OF THE CELL

Next-generation proteomics: towards an integrative view of proteome dynamics

(2012) A. F. Maarten Altelaar et al.   NATURE REVIEWS GENETICS

The nuclear lamins: flexibility in function

(2012) Brian Burke et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for heteromeric assembly and perinuclear organization of keratin filaments

(2012) Chang-Hun Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lamin A/C Mutants Disturb Sumo1 Localization and Sumoylation in Vitro and in Vivo

(2012) Émilie Boudreau et al.   PLoS One

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

(2012) L. B. Gordon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Cross Talk Between O-GlcNAcylation and Phosphorylation: Roles in Signaling, Transcription, and Chronic Disease

(2011) Gerald W. Hart et al.   Annual Review of Biochemistry

Treatment with selumetinib preserves cardiac function and improves survival in cardiomyopathy caused by mutation in the lamin A/C gene

(2011) A. Muchir et al.   CARDIOVASCULAR RESEARCH

Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia

(2011) Reinhard Windoffer et al.   JOURNAL OF CELL BIOLOGY

Differential roles of kinesin and dynein in translocation of neurofilaments into axonal neurites

(2011) S. Lee et al.   JOURNAL OF CELL SCIENCE

Nestin Is Not Essential for Development of the CNS But Required for Dispersion of Acetylcholine Receptor Clusters at the Area of Neuromuscular Junctions

(2011) P. Mohseni et al.   JOURNAL OF NEUROSCIENCE

Inroads into the structure and function of intermediate filament networks

(2011) Robert D. Goldman et al.   JOURNAL OF STRUCTURAL BIOLOGY

The First Identification of Lysine Malonylation Substrates and Its Regulatory Enzyme

(2011) Chao Peng et al.   MOLECULAR & CELLULAR PROTEOMICS

The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9

(2011) J. B. Kelley et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

Nestin negatively regulates postsynaptic differentiation of the neuromuscular synapse

(2011) Jiefei Yang et al.   NATURE NEUROSCIENCE

GFAP mutations, age at onset, and clinical subtypes in Alexander disease

(2011) M. Prust et al.   NEUROLOGY

Loss of Keratin 8 Phosphorylation Leads to Increased Tumor Progression and Correlates with Clinico-Pathological Parameters of OSCC Patients

(2011) Hunain Alam et al.   PLoS One

14-3-3 Proteins: Diverse functions in cell proliferation and cancer progression

(2011) Alyson K. Freeman et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Maribavir and human cytomegalovirus—what happened in the clinical trials and why might the drug have failed?

(2011) Francisco M Marty et al.   Current Opinion in Virology

Breach of the nuclear lamina during assembly of herpes simplex viruses

(2011) Lynda A. Morrison et al.   Nucleus

Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice

(2010) Young Sun Oh et al.   AGING CELL

Quantitative phosphoproteomic analysis of neuronal intermediate filament proteins (NF-M/H) in Alzheimer's disease by iTRAQ

(2010) Parvathi Rudrabhatla et al.   FASEB JOURNAL

Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

(2010) Melissa G. Mendez et al.   FASEB JOURNAL

Keratin Variants Predispose to Acute Liver Failure and Adverse Outcome: Race and Ethnic Associations

(2010) Pavel Strnad et al.   GASTROENTEROLOGY

Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice

(2010) Maud D. Demarque et al.   GASTROENTEROLOGY

The ubiquitin ligase CHIP/STUB1 targets mutant keratins for degradation

(2010) Stefanie Löffek et al.   HUMAN MUTATION

Keratin Hypersumoylation Alters Filament Dynamics and Is a Marker for Human Liver Disease and Keratin Mutation

(2010) Natasha T. Snider et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomers of Mutant Glial Fibrillary Acidic Protein (GFAP) Inhibit the Proteasome System in Alexander Disease Astrocytes, and the Small Heat Shock Protein αB-Crystallin Reverses the Inhibition

(2010) Guomei Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel Mode of Phosphorylation-triggered Reorganization of the Nuclear Lamina during Nuclear Egress of Human Cytomegalovirus

(2010) Jens Milbradt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin, microtubules, and vimentin intermediate filaments cooperate for elongation of invadopodia

(2010) Marie Schoumacher et al.   JOURNAL OF CELL BIOLOGY

Specific phosphorylation of Ser458 of A-type lamins in LMNA-associated myopathy patients

(2010) H. Mitsuhashi et al.   JOURNAL OF CELL SCIENCE

Autophagy Regulates Keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors

(2010) S. Kongara et al.   MOLECULAR CANCER RESEARCH

Cytoskeletal keratin glycosylation protects epithelial tissue from injury

(2010) Nam-On Ku et al.   NATURE CELL BIOLOGY

Generation of acetyllysine antibodies and affinity enrichment of acetylated peptides

(2010) Kun-Liang Guan et al.   Nature Protocols

Vimentin is a novel AKT1 target mediating motility and invasion

(2010) Q-S Zhu et al.   ONCOGENE

Characterization of In Vivo Keratin 19 Phosphorylation on Tyrosine-391

(2010) Qin Zhou et al.   PLoS One

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Akt-RSK-S6 Kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

(2010) A. Moritz et al.   Science Signaling

Intermediate filaments take the heat as stress proteins

(2010) D.M. Toivola et al.   TRENDS IN CELL BIOLOGY

SUMO Regulates the Assembly and Function of a Cytoplasmic Intermediate Filament Protein in C. elegans

(2009) Rachel Kaminsky et al.   DEVELOPMENTAL CELL

Phosphorylation-dependent binding of human transcription factor MOK2 to lamin A/C

(2009) Maryannick Harper et al.   FEBS Journal

Suppression of GFAP toxicity by αB-crystallin in mouse models of Alexander disease

(2009) Tracy L. Hagemann et al.   HUMAN MOLECULAR GENETICS

Neurofilament cross-bridging competes with kinesin-dependent association of neurofilaments with microtubules

(2009) J. Kushkuley et al.   JOURNAL OF CELL SCIENCE

Dysfunctions of neuronal and glial intermediate filaments in disease

(2009) Ronald K.H. Liem et al.   JOURNAL OF CLINICAL INVESTIGATION

Laminopathies and the long strange trip from basic cell biology to therapy

(2009) Howard J. Worman et al.   JOURNAL OF CLINICAL INVESTIGATION

Introducing intermediate filaments: from discovery to disease

(2009) John E. Eriksson et al.   JOURNAL OF CLINICAL INVESTIGATION

“IF-pathies”: a broad spectrum of intermediate filament–associated diseases

(2009) M. Bishr Omary   JOURNAL OF CLINICAL INVESTIGATION

Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility

(2009) Pierre A. Coulombe et al.   JOURNAL OF CLINICAL INVESTIGATION

Intermediate filaments: primary determinants of cell architecture and plasticity

(2009) Harald Herrmann et al.   JOURNAL OF CLINICAL INVESTIGATION

Tragedy in a heartbeat: malfunctioning desmin causes skeletal and cardiac muscle disease

(2009) Lev G. Goldfarb et al.   JOURNAL OF CLINICAL INVESTIGATION

Toward unraveling the complexity of simple epithelial keratins in human disease

(2009) M. Bishr Omary et al.   JOURNAL OF CLINICAL INVESTIGATION

Peptidyl-Prolyl Isomerase 1 Regulates Protein Phosphatase 2A-Mediated Topographic Phosphorylation of Neurofilament Proteins

(2009) P. Rudrabhatla et al.   JOURNAL OF NEUROSCIENCE

Shear Stress Induced Reorganization of the Keratin Intermediate Filament Network Requires Phosphorylation by Protein Kinase C ζ

(2009) Sivaraj Sivaramakrishnan et al.   MOLECULAR BIOLOGY OF THE CELL

Emerging role for the cytoskeleton as an organizer and regulator of translation

(2009) Seyun Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Declining phosphatases underlie aging-related hyperphosphorylation of neurofilaments

(2009) Veeranna et al.   NEUROBIOLOGY OF AGING

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Actin-dependent dynamics of keratin filament precursors

(2009) Anne Kölsch et al.   CELL MOTILITY AND THE CYTOSKELETON

Intermediate filaments inCaenorhabditis elegans

(2009) Katrin Carberry et al.   CELL MOTILITY AND THE CYTOSKELETON

Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress

(2009) Sofia Hamirally et al.   PLoS Pathogens

Regulation of neurofilament dynamics by phosphorylation

(2008) Thomas B. Shea et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Providing cellular signposts - Post-translational modifications of intermediate filaments

(2008) Claire L. Hyder et al.   FEBS LETTERS

AMP-activated Protein Kinase and p38 MAPK ActivateO-GlcNAcylation of Neuronal Proteins during Glucose Deprivation

(2008) Win D. Cheung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitin-Proteasome-mediated Degradation of Keratin Intermediate Filaments in Mechanically Stimulated A549 Cells

(2008) Ariel Jaitovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sumoylation regulates lamin A function and is lost in lamin A mutants associated with familial cardiomyopathies

(2008) Yu-Qian Zhang et al.   JOURNAL OF CELL BIOLOGY

A Mitotic GlcNAcylation/Phosphorylation Signaling Complex Alters the Posttranslational State of the Cytoskeletal Protein Vimentin

(2008) Chad Slawson et al.   MOLECULAR BIOLOGY OF THE CELL

Kinase-Selective Enrichment Enables Quantitative Phosphoproteomics of the Kinome across the Cell Cycle

(2008) Henrik Daub et al.   MOLECULAR CELL

Lysine Acetylation: Codified Crosstalk with Other Posttranslational Modifications

(2008) Xiang-Jiao Yang et al.   MOLECULAR CELL

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Signaling networks assembled by oncogenic EGFR and c-Met

(2008) A. Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation between O-GlcNAcylation and phosphorylation of neurofilament-M and their dysregulation in Alzheimer disease

(2007) Yanqiu Deng et al.   FASEB JOURNAL