High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
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Title
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
Authors
Keywords
Nav1.7, SCN9A, pain, Huwentoxin IV, Protoxin II, cryo-EM structures, allosteric modulation, π helix, fast inactivation, channel gating
Journal
Cell Reports
Volume 39, Issue 4, Pages 110735
Publisher
Elsevier BV
Online
2022-04-26
DOI
10.1016/j.celrep.2022.110735
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