High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
出版年份 2022 全文链接
标题
High-resolution structures of human Nav1.7 reveal gating modulation through α-π helical transition of S6IV
作者
关键词
Nav1.7, SCN9A, pain, Huwentoxin IV, Protoxin II, cryo-EM structures, allosteric modulation, π helix, fast inactivation, channel gating
出版物
Cell Reports
Volume 39, Issue 4, Pages 110735
出版商
Elsevier BV
发表日期
2022-04-26
DOI
10.1016/j.celrep.2022.110735
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Structural Basis for Pore Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug Quinidine
- (2021) Zhangqiang Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Comparative structural analysis of human Nav1.1 and Nav1.5 reveals mutational hotspots for sodium channelopathies
- (2021) Xiaojing Pan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Highly accurate protein structure prediction with AlphaFold
- (2021) John Jumper et al. NATURE
- Highly accurate protein structure prediction for the human proteome
- (2021) Kathryn Tunyasuvunakool et al. NATURE
- Structure of human Cav2.2 channel blocked by the painkiller ziconotide
- (2021) Shuai Gao et al. NATURE
- Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc
- (2020) Shuai Gao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin
- (2020) Goragot Wisedchaisri et al. MOLECULAR CELL
- Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
- (2020) Ali Punjani et al. NATURE METHODS
- Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin
- (2019) Hui Xu et al. CELL
- Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA
- (2019) Xiaojing Pan et al. SCIENCE
- Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins
- (2019) Huaizong Shen et al. SCIENCE
- Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+ Channel
- (2019) Yanyu Zhao et al. CELL
- Hydrated Sodium Ion Clusters [Na+(H2O)n (n = 1–6)]: An ab initio Study on Structures and Non-covalent Interaction
- (2019) Pengju Wang et al. Frontiers in Chemistry
- The role of π-helices in TRP channel gating
- (2019) Lejla Zubcevic et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Cryo-EM structures of apo and antagonist-bound human Cav3.1
- (2019) Yanyu Zhao et al. NATURE
- Cryo-EM structure of the polycystic kidney disease-like channel PKD2L1
- (2018) Qiang Su et al. Nature Communications
- Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1
- (2018) Xiaojing Pan et al. SCIENCE
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- Revisiting the hydration structure of aqueous Na+
- (2017) M. Galib et al. JOURNAL OF CHEMICAL PHYSICS
- Opening of the human epithelial calcium channel TRPV6
- (2017) Luke L. McGoldrick et al. NATURE
- MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy
- (2017) Shawn Q Zheng et al. NATURE METHODS
- cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
- (2017) Ali Punjani et al. NATURE METHODS
- Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution
- (2017) Huaizong Shen et al. SCIENCE
- Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief
- (2016) Edward C Emery et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Gctf: Real-time CTF determination and correction
- (2016) Kai Zhang JOURNAL OF STRUCTURAL BIOLOGY
- Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution
- (2016) Jianping Wu et al. NATURE
- Voltage gated sodium channels as drug discovery targets
- (2015) Sharan K Bagal et al. Channels
- Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications
- (2015) Manuel de Lera Ruiz et al. JOURNAL OF MEDICINAL CHEMISTRY
- Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6
- (2015) Timothy Grant et al. eLife
- Structure of the Yeast Mitochondrial Large Ribosomal Subunit
- (2014) A. Amunts et al. SCIENCE
- High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy
- (2013) Shaoxia Chen et al. ULTRAMICROSCOPY
- The Role of a Voltage-Dependent Ca2+ Channel Intracellular Linker: A Structure-Function Analysis
- (2012) L. Almagor et al. JOURNAL OF NEUROSCIENCE
- Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker
- (2011) Yigal Paul Goldberg et al. PAIN
- Features and development ofCoot
- (2010) P. Emsley et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration
- (2008) Yucheng Xiao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors
- (2008) W. A. Schmalhofer et al. MOLECULAR PHARMACOLOGY
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