Structural Basis for High-Affinity Trapping of the NaV1.7 Channel in Its Resting State by Tarantula Toxin

Employing NaChBac for cryo-EM analysis of toxin action on voltage-gated Na+channels in nanodisc

(2020) Shuai Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

(2019) Hui Xu et al.   CELL

Molecular basis for pore blockade of human Na+ channel Nav1.2 by the μ-conotoxin KIIIA

(2019) Xiaojing Pan et al.   SCIENCE

Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

(2019) Huaizong Shen et al.   SCIENCE

Structural insight into TRPV5 channel function and modulation

(2019) Shangyu Dang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel

(2019) Goragot Wisedchaisri et al.   CELL

Structure of the Cardiac Sodium Channel

(2019) Daohua Jiang et al.   CELL

cisTEM, user-friendly software for single-particle image processing

(2018) Timothy Grant et al.   eLife

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Mechanism of calmodulin inactivation of the calcium-selective TRP channel TRPV6

(2018) Appu K. Singh et al.   Science Advances

A Functional Na V 1.7-Na V Ab Chimera with a Reconstituted High-Affinity ProTx-II Binding Site

(2017) Ramkumar Rajamani et al.   MOLECULAR PHARMACOLOGY

The chemical basis for electrical signaling

(2017) William A Catterall et al.   Nature Chemical Biology

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

The complete structure of an activated open sodium channel

(2017) Altin Sula et al.   Nature Communications

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant

(2017) Sassan Rahnama et al.   PLoS One

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structures of MBP fusion proteins

(2016) David S. Waugh   PROTEIN SCIENCE

The hitchhiker’s guide to the voltage-gated sodium channel galaxy

(2015) Christopher A. Ahern et al.   JOURNAL OF GENERAL PHYSIOLOGY

Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels

(2015) Tianfu Cai et al.   PEPTIDES

Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist

(2015) S. Ahuja et al.   SCIENCE

A gating charge interaction required for late slow inactivation of the bacterial sodium channel NavAb

(2013) Tamer M. Gamal El-Din et al.   JOURNAL OF GENERAL PHYSIOLOGY

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Potency optimization of Huwentoxin-IV on hNav1.7: A neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena

(2013) Jefferson D. Revell et al.   PEPTIDES

Mapping the Interaction Site for a β-Scorpion Toxin in the Pore Module of Domain III of Voltage-gated Na+Channels

(2012) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

Crystal structure of a voltage-gated sodium channel in two potentially inactivated states

(2012) Jian Payandeh et al.   NATURE

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Outcome of the First Electron Microscopy Validation Task Force Meeting

(2012) Richard Henderson et al.   STRUCTURE

Spider-venom peptides that target voltage-gated sodium channels: Pharmacological tools and potential therapeutic leads

(2012) Julie K. Klint et al.   TOXICON

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-Function Map of the Receptor Site for β-Scorpion Toxins in Domain II of Voltage-gated Sodium Channels

(2011) Joel Z. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Structural basis for gating charge movement in the voltage sensor of a sodium channel

(2011) V. Yarov-Yarovoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON