Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications

(2015) Manuel de Lera Ruiz et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel SCN9A Mutations Underlying Extreme Pain Phenotypes: Unexpected Electrophysiological and Clinical Phenotype Correlations

(2015) E. C. Emery et al.   JOURNAL OF NEUROSCIENCE

The Role of Nav1.9 Channel in the Development of Neuropathic Orofacial Pain Associated with Trigeminal Neuralgia

(2015) Ana Paula Lulz et al.   Molecular Pain

NaV1.9: a sodium channel linked to human pain

(2015) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy

(2015) Chongyang Han et al.   NEUROMOLECULAR MEDICINE

Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia

(2015) Jennifer Koenig et al.   PLoS One

Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain

(2015) Sharan K. Bagal et al.   ACS Medicinal Chemistry Letters

Cold-aggravated pain in humans caused by a hyperactive NaV1.9 channel mutant

(2015) Enrico Leipold et al.   Nature Communications

Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7

(2015) Michael S. Minett et al.   Nature Communications

Gain-of-function mutations in sodium channel NaV1.9 in painful neuropathy

(2014) Jianying Huang et al.   BRAIN

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

New investigational drugs for the treatment of neuropathic pain

(2014) Kinga Sałat et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

New Orally Active Dual Enkephalinase Inhibitors (DENKIs) for Central and Peripheral Pain Treatment

(2014) Hervé Poras et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Beta-2 as a Key Cell Adhesion Molecule in PCa Cell Neurotropic Behavior: A Novel Ex Vivo and Biophysical Approach

(2014) Keith H. Jansson et al.   PLoS One

Significant Determinants of Mouse Pain Behaviour

(2014) Michael S. Minett et al.   PLoS One

Transgene Regulation Using the Tetracycline-Inducible TetR-KRAB System after AAV-Mediated Gene Transfer in Rodents and Nonhuman Primates

(2014) Caroline Le Guiner et al.   PLoS One

Chemical–genetic attenuation of focal neocortical seizures

(2014) Dennis Kätzel et al.   Nature Communications

Pain without Nociceptors? Nav1.7-Independent Pain Mechanisms

(2014) Michael S. Minett et al.   Cell Reports

Gain-of-Function Mutations in SCN11A Cause Familial Episodic Pain

(2013) Xiang Yang Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Inherited Pain

(2013) Mirjam Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The G1662S NaV1.8 mutation in small fibre neuropathy: impaired inactivation underlying DRG neuron hyperexcitability

(2013) C. Han et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Small-Fiber Neuropathy Nav1.8 Mutation Shifts Activation to Hyperpolarized Potentials and Increases Excitability of Dorsal Root Ganglion Neurons

(2013) J. Huang et al.   JOURNAL OF NEUROSCIENCE

Nav1.7: Stress-Induced Changes in Immunoreactivity within Magnocellular Neurosecretory Neurons of the Supraoptic Nucleus

(2013) Joel A Black et al.   Molecular Pain

A de novo gain-of-function mutation in SCN11A causes loss of pain perception

(2013) Enrico Leipold et al.   NATURE GENETICS

Magnetic Resonance Neurography–Guided Nerve Blocks for the Diagnosis and Treatment of Chronic Pelvic Pain Syndrome

(2013) Jan Fritz et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Painful Na-channelopathies: an expanding universe

(2013) Stephen G. Waxman   TRENDS IN MOLECULAR MEDICINE

Neurological perspectives on voltage-gated sodium channels

(2012) N. Eijkelkamp et al.   BRAIN

Voltage-gated sodium channels and metastatic disease

(2012) William J. Brackenbury   Channels

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

(2012) Tao Yang et al.   CIRCULATION RESEARCH

Functional Na V 1.8 Channels in Intracardiac Neurons

(2012) Arie O. Verkerk et al.   CIRCULATION RESEARCH

pH regulators in invadosomal functioning: Proton delivery for matrix tasting

(2012) Lucie Brisson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

The NaV1.7 sodium channel: from molecule to man

(2012) Sulayman D. Dib-Hajj et al.   NATURE REVIEWS NEUROSCIENCE

Gain-of-function Nav1.8 mutations in painful neuropathy

(2012) C. G. Faber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Loss-of-function mutations in sodium channel Nav1.7 cause anosmia

(2011) Jan Weiss et al.   NATURE

Nav1.9 Channel Contributes to Mechanical and Heat Pain Hypersensitivity Induced by Subacute and Chronic Inflammation

(2011) Stéphane Lolignier et al.   PLoS One

Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navβ4 peptide-mediated resurgent sodium currents

(2010) Jonathan W. Theile et al.   JOURNAL OF PHYSIOLOGY-LONDON

Several common variants modulate heart rate, PR interval and QRS duration

(2010) Hilma Holm et al.   NATURE GENETICS

Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction

(2010) Nona Sotoodehnia et al.   NATURE GENETICS

Genome-wide association study of PR interval

(2010) Arne Pfeufer et al.   NATURE GENETICS

Genetic variation in SCN10A influences cardiac conduction

(2010) John C Chambers et al.   NATURE GENETICS

NaV1.5 enhances breast cancer cell invasiveness by increasing NHE1-dependent H+ efflux in caveolae

(2010) L Brisson et al.   ONCOGENE

A sodium channel geneSCN9Apolymorphism that increases nociceptor excitability

(2009) Mark Estacion et al.   ANNALS OF NEUROLOGY

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1.8 and Nav1.9 knockout mice

(2009) Sandra Leo et al.   BEHAVIOURAL BRAIN RESEARCH

GPCR Theme Editorial

(2009) G Milligan et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE