Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins

Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1

(2018) Xiaojing Pan et al.   SCIENCE

Structural basis for the modulation of voltage-gated sodium channels by animal toxins

(2018) Huaizong Shen et al.   SCIENCE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution

(2017) Huaizong Shen et al.   SCIENCE

Structure-based assessment of disease-related mutations in human voltage-gated sodium channels

(2017) Weiyun Huang et al.   Protein & Cell

Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief

(2016) Edward C Emery et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7

(2016) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2

(2016) Dari Kimanius et al.   eLife

Sodium Channel β Subunits: Emerging Targets in Channelopathies

(2015) Heather A. O'Malley et al.   Annual Review of Physiology

Semi-automated selection of cryo-EM particles in RELION-1.3

(2015) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6

(2015) Timothy Grant et al.   eLife

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Painful and painless channelopathies

(2014) David L H Bennett et al.   LANCET NEUROLOGY

Screening and large-scale expression of membrane proteins in mammalian cells for structural studies

(2014) April Goehring et al.   Nature Protocols

Structure of the Yeast Mitochondrial Large Ribosomal Subunit

(2014) A. Amunts et al.   SCIENCE

Inherited Pain

(2013) Mirjam Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Shellfish Toxins Targeting Voltage-Gated Sodium Channels

(2013) Fan Zhang et al.   Marine Drugs

Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models

(2013) S. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-resolution noise substitution to measure overfitting and validate resolution in 3D structure determination by single particle electron cryomicroscopy

(2013) Shaoxia Chen et al.   ULTRAMICROSCOPY

β1- and β3- voltage-gated sodium channel subunits modulate cell surface expression and glycosylation of Nav1.7 in HEK293 cells

(2013) Cédric J. Laedermann et al.   Frontiers in Cellular Neuroscience

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

(2012) Francisco Rafael Nieto et al.   Marine Drugs

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Molecular Determinants of Tarantula Huwentoxin-IV Inhibition of Na+Channel Voltage Sensors in Domains II and IV

(2011) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Treatment of Nav1.7-mediated pain in inherited erythromelalgia using a novel sodium channel blocker

(2011) Yigal Paul Goldberg et al.   PAIN

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Tarantula Toxins ProTx-II and Huwentoxin-IV Differentially Interact with Human Nav1.7 Voltage Sensors to Inhibit Channel Activation and Inactivation

(2010) Y. Xiao et al.   MOLECULAR PHARMACOLOGY

A Gating Charge Transfer Center in Voltage Sensors

(2010) X. Tao et al.   SCIENCE

Early- and late-onset inherited erythromelalgia: genotype–phenotype correlation

(2009) Chongyang Han et al.   BRAIN

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Spectrum and prevalence of mutations from the first 2,500 consecutive unrelated patients referred for the FAMILION® long QT syndrome genetic test

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

An international compendium of mutations in the SCN5A-encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing

(2009) Jamie D. Kapplinger et al.   HEART RHYTHM

Site-specific analgesia with sustained release liposomes

(2009) M. Chorny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

(2008) Neil A. Hagen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE