Mitochondrial-to-nuclear communication in aging: an epigenetic perspective

α‐ketoglutarate delays age‐related fertility decline in mammals

(2021) Zhenzhen Zhang et al.   AGING CELL

Epigenetics of Aging and Aging-Associated Diseases

(2021) Dominik Saul et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation

(2021) Ann-Katrin Hopp et al.   MOLECULAR CELL

Brain NAD Is Associated With ATP Energy Production and Membrane Phospholipid Turnover in Humans

(2021) Bernard Cuenoud et al.   Frontiers in Aging Neuroscience

Mitohormesis in Hypothalamic POMC Neurons Mediates Regular Exercise-Induced High-Turnover Metabolism

(2021) Gil Myoung Kang et al.   Cell Metabolism

Neuronal mitochondrial dynamics coordinate systemic mitochondrial morphology and stress response to confer pathogen resistance in C. elegans

(2021) Li-Tzu Chen et al.   DEVELOPMENTAL CELL

Acetyl-CoA Metabolism and Histone Acetylation in the Regulation of Aging and Lifespan

(2021) Patrick C. Bradshaw   Antioxidants

Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

(2021) Alicia G. Gómez-Valadés et al.   Cell Metabolism

The memory of neuronal mitochondrial stress is inherited transgenerationally via elevated mitochondrial DNA levels

(2021) Qian Zhang et al.   NATURE CELL BIOLOGY

Daily energy expenditure through the human life course

(2021) Herman Pontzer et al.   SCIENCE

Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test

(2021) Oleksandr Demidenko et al.   Aging-US

A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging

(2020) Haopeng Xiao et al.   CELL

Interplay between compartmentalized NAD+ synthesis and consumption: a focus on the PARP family

(2020) Michael S. Cohen   GENES & DEVELOPMENT

Mitochondrial TCA cycle metabolites control physiology and disease

(2020) Inmaculada Martínez-Reyes et al.   Nature Communications

Systemic effects of mitochondrial stress

(2020) Raz Bar‐Ziv et al.   EMBO REPORTS

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

(2020) Gabriela Desdín-Micó et al.   SCIENCE

Metabolism and the Epigenome: A Dynamic Relationship

(2020) Spencer A. Haws et al.   TRENDS IN BIOCHEMICAL SCIENCES

NAD+ Regeneration Rescues Lifespan, but Not Ataxia, in a Mouse Model of Brain Mitochondrial Complex I Dysfunction

(2020) Gregory S. McElroy et al.   Cell Metabolism

NuRD mediates mitochondrial stress–induced longevity via chromatin remodeling in response to acetyl-CoA level

(2020) Di Zhu et al.   Science Advances

Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

(2020) Ke Zou et al.   Science Advances

Targeting metabolic pathways for extension of lifespan and healthspan across multiple species

(2020) Andrey A. Parkhitko et al.   AGEING RESEARCH REVIEWS

Alpha-Ketoglutarate, an Endogenous Metabolite, Extends Lifespan and Compresses Morbidity in Aging Mice

(2020) Azar Asadi Shahmirzadi et al.   Cell Metabolism

Histone deacetylase HDA-1 modulates mitochondrial stress response and longevity

(2020) Li-Wa Shao et al.   Nature Communications

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Alpha-ketoglutarate extends Drosophila lifespan by inhibiting mTOR and activating AMPK

(2019) Yuan Su et al.   Aging-US

Regulation of nuclear epigenome by mitochondrial DNA heteroplasmy

(2019) Piotr K. Kopinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species

(2019) Andrey A. Parkhitko et al.   AGING CELL

Mitochondria orchestrate proteostatic and metabolic stress responses

(2019) Claes Andréasson et al.   EMBO REPORTS

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Mitocellular communication: Shaping health and disease

(2019) Adrienne Mottis et al.   SCIENCE

Elevating acetyl-CoA levels reduces aspects of brain aging

(2019) Antonio Currais et al.   eLife

Developmental ROS individualizes organismal stress resistance and lifespan

(2019) Daphne Bazopoulou et al.   NATURE

Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation

(2018) Sharanya Sivanand et al.   TRENDS IN BIOCHEMICAL SCIENCES

Teaching the basics of reactive oxygen species and their relevance to cancer biology: Mitochondrial reactive oxygen species detection, redox signaling, and targeted therapies

(2018) Balaraman Kalyanaraman et al.   Redox Biology

The Multiple Levels of Mitonuclear Coregulation

(2018) R. Stefan Isaac et al.   Annual Review of Genetics

The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling

(2018) Qian Zhang et al.   CELL

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Genetic variation in glia–neuron signalling modulates ageing rate

(2017) Jiang-An Yin et al.   NATURE

Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory

(2017) Philipp Mews et al.   NATURE

Biphasic Modeling of Mitochondrial Metabolism Dysregulation during Aging

(2017) Darren J. Baker et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mitochondria and Epigenetics – Crosstalk in Homeostasis and Stress

(2017) Olli Matilainen et al.   TRENDS IN CELL BIOLOGY

NAD + in Aging: Molecular Mechanisms and Translational Implications

(2017) Evandro F. Fang et al.   TRENDS IN MOLECULAR MEDICINE

Caloric restriction delays age-related methylation drift

(2017) Shinji Maegawa et al.   Nature Communications

Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity: Well-Known and Novel Possibilities of Therapeutic Use

(2016) Barbara Zdzisińska et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity

(2016) Carsten Merkwirth et al.   CELL

Mitochondrial Stress Induces Chromatin Reorganization to Promote Longevity and UPR mt

(2016) Ye Tian et al.   CELL

Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

(2016) Kristen M. Berendzen et al.   CELL

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

(2016) Evandro Fei Fang et al.   Cell Metabolism

Neuropeptide signals cell non-autonomous mitochondrial unfolded protein response

(2016) Li-Wa Shao et al.   CELL RESEARCH

Life span extension by targeting a link between metabolism and histone acetylation inDrosophila

(2016) Shahaf Peleg et al.   EMBO REPORTS

Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span inDrosophila

(2016) Andrey A. Parkhitko et al.   GENES & DEVELOPMENT

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Metabolite concentrations, fluxes and free energies imply efficient enzyme usage

(2016) Junyoung O Park et al.   Nature Chemical Biology

Cardioprotection and lifespan extension by the natural polyamine spermidine

(2016) Tobias Eisenberg et al.   NATURE MEDICINE

Mitonuclear communication in homeostasis and stress

(2016) Pedro M. Quirós et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice

(2016) H. Zhang et al.   SCIENCE

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders

(2015) Shuichi Yatsuga et al.   ANNALS OF NEUROLOGY

A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging

(2015) Mark A. McCormick et al.   Cell Metabolism

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

2-Hydroxyglutarate Inhibits ATP Synthase and mTOR Signaling

(2015) Xudong Fu et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Acetyl-CoA and the regulation of metabolism: mechanisms and consequences

(2015) Lei Shi et al.   CURRENT OPINION IN CELL BIOLOGY

Enhancing S-adenosyl-methionine catabolism extends Drosophila lifespan

(2015) Fumiaki Obata et al.   Nature Communications

Effects of nutritional components on aging

(2014) Dongyeop Lee et al.   AGING CELL

Spermidine induces autophagy by inhibiting the acetyltransferase EP300

(2014) F Pietrocola et al.   CELL DEATH AND DIFFERENTIATION

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

(2014) B. J. North et al.   EMBO JOURNAL

The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

(2014) Randall M. Chin et al.   NATURE

Mitoflash frequency in early adulthood predicts lifespan in Caenorhabditis elegans

(2014) En-Zhi Shen et al.   NATURE

Methionine Restriction Activates the Retrograde Response and Confers Both Stress Tolerance and Lifespan Extension to Yeast, Mouse and Human Cells

(2014) Jay E. Johnson et al.   PLoS One

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

(2014) Christopher F. Bennett et al.   Nature Communications

Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status

(2014) Byung Cheon Lee et al.   Nature Communications

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

Muscle Mitohormesis Promotes Longevity via Systemic Repression of Insulin Signaling

(2013) Edward Owusu-Ansah et al.   CELL

Epigenetic Silencing Mediates Mitochondria Stress-Induced Longevity

(2013) Elizabeth A. Schroeder et al.   Cell Metabolism

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

(2013) Clare B. Edwards et al.   PLoS One

A metabolic signature for long life in theCaenorhabditis elegansMit mutants

(2012) Jeffrey A. Butler et al.   AGING CELL

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

The Cell-Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

(2011) Jenni Durieux et al.   CELL

FGF-21 as a biomarker for muscle-manifesting mitochondrial respiratory chain deficiencies: a diagnostic study

(2011) Anu Suomalainen et al.   LANCET NEUROLOGY

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

A novel role for mitochondria in regulating epigenetic modifications in the nucleus

(2010) Dominic Smiraglia et al.   CANCER BIOLOGY & THERAPY

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

(2010) Daniel Herranz et al.   Nature Communications

Extension of Drosophila Life Span by RNAi of the Mitochondrial Respiratory Chain

(2009) Jeffrey M. Copeland et al.   CURRENT BIOLOGY

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Induction of autophagy by spermidine promotes longevity

(2009) Tobias Eisenberg et al.   NATURE CELL BIOLOGY

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA