Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Redox Stability Controls the Cellular Uptake and Activity of Ruthenium-Based Inhibitors of the Mitochondrial Calcium Uniporter (MCU)

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Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells

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Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

(2020) Roberta Haddad-Tóvolli et al.   Molecular Metabolism

A leptin–BDNF pathway regulating sympathetic innervation of adipose tissue

(2020) Putianqi Wang et al.   NATURE

Regulation of substrate utilization and adiposity by Agrp neurons

(2019) João Paulo Cavalcanti-de-Albuquerque et al.   Nature Communications

A Selective and Cell-Permeable Mitochondrial Calcium Uniporter (MCU) Inhibitor Preserves Mitochondrial Bioenergetics after Hypoxia/Reoxygenation Injury

(2019) Joshua J. Woods et al.   ACS Central Science

DRP1-mediated mitochondrial shape controls calcium homeostasis and muscle mass

(2019) Giulia Favaro et al.   Nature Communications

MICU1 controls cristae junction and spatially anchors mitochondrial Ca2+ uniporter complex

(2019) Benjamin Gottschalk et al.   Nature Communications

Inhibitors of the mitochondrial calcium uniporter for the treatment of disease

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(2018) Lisa Tilokani et al.   Essays in Biochemistry

MCU Interacts with Miro1 to Modulate Mitochondrial Functions in Neurons

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Leptin and brain–adipose crosstalks

(2018) Alexandre Caron et al.   NATURE REVIEWS NEUROSCIENCE

MICU1 Interacts with the D-Ring of the MCU Pore to Control Its Ca2+ Flux and Sensitivity to Ru360

(2018) Melanie Paillard et al.   MOLECULAR CELL

Systematic Identification of MCU Modulators by Orthogonal Interspecies Chemical Screening

(2017) Daniela M. Arduino et al.   MOLECULAR CELL

A molecular census of arcuate hypothalamus and median eminence cell types

(2017) John N Campbell et al.   NATURE NEUROSCIENCE

OPA1 Isoforms in the Hierarchical Organization of Mitochondrial Functions

(2017) Valentina Del Dotto et al.   Cell Reports

Energy imbalance alters Ca2+ handling and excitability of POMC neurons

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Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing

(2017) Brian Y.H. Lam et al.   Molecular Metabolism

UCP2 Regulates Mitochondrial Fission and Ventromedial Nucleus Control of Glucose Responsiveness

(2016) Chitoku Toda et al.   CELL

Miro1‐dependent mitochondrial positioning drives the rescaling of presynaptic Ca 2+ signals during homeostatic plasticity

(2016) Victoria Vaccaro et al.   EMBO REPORTS

Metabolic regulation of mitochondrial dynamics

(2016) Prashant Mishra et al.   JOURNAL OF CELL BIOLOGY

Mitofusins, from Mitochondria to Metabolism

(2016) Emilie Schrepfer et al.   MOLECULAR CELL

Mitochondrial Cristae: Where Beauty Meets Functionality

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Mitochondrial Dynamics and Metabolic Regulation

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Joint mouse–human phenome-wide association to test gene function and disease risk

(2016) Xusheng Wang et al.   Nature Communications

EMRE Is a Matrix Ca 2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca 2+ Uniporter

(2016) Horia Vais et al.   Cell Reports

Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis

(2015) Wenwen Zeng et al.   CELL

Sensory Detection of Food Rapidly Modulates Arcuate Feeding Circuits

(2015) Yiming Chen et al.   CELL

Mitochondrial Ca2+ uptake correlates with the severity of the symptoms in autosomal dominant optic atrophy

(2015) László Fülöp et al.   CELL CALCIUM

Opa1 Overexpression Ameliorates the Phenotype of Two Mitochondrial Disease Mouse Models

(2015) Gabriele Civiletto et al.   Cell Metabolism

Hypothalamic POMC neurons promote cannabinoid-induced feeding

(2015) Marco Koch et al.   NATURE

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

(2014) Prashant Mishra et al.   Cell Metabolism

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

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Mitochondrial response to nutrient availability and its role in metabolic disease

(2014) A. W. Gao et al.   EMBO Molecular Medicine

Neural innervation of white adipose tissue and the control of lipolysis

(2014) Timothy J. Bartness et al.   FRONTIERS IN NEUROENDOCRINOLOGY

OPA1 loss of function affects in vitro neuronal maturation

(2013) Ambre M. Bertholet et al.   BRAIN

Mitochondrial Cristae Shape Determines Respiratory Chain Supercomplexes Assembly and Respiratory Efficiency

(2013) Sara Cogliati et al.   CELL

Mitochondrial Dynamics Controlled by Mitofusins Regulate Agrp Neuronal Activity and Diet-Induced Obesity

(2013) Marcelo O. Dietrich et al.   CELL

Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance

(2013) Marc Schneeberger et al.   CELL

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Loss of OPA1 disturbs cellular calcium homeostasis and sensitizes for excitotoxicity

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

(2011) Joshua M. Baughman et al.   NATURE

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

(2011) Diego De Stefani et al.   NATURE

During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

(2011) Ligia C. Gomes et al.   NATURE CELL BIOLOGY

The Effect of OPA1 on Mitochondrial Ca2+ Signaling

(2011) László Fülöp et al.   PLoS One

Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons

(2011) K. T. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

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(2009) E. Sanz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation

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Lipolysis and the integrated physiology of lipid energy metabolism

(2008) Shupei Wang et al.   MOLECULAR GENETICS AND METABOLISM

Leptin controls adipose tissue lipogenesis via central, STAT3–independent mechanisms

(2008) Christoph Buettner et al.   NATURE MEDICINE