Effects of nutritional components on aging

Growth signaling promotes chronological aging in budding yeast by inducing superoxide anions that inhibit quiescence

(2016) Martin Weinberger et al.   Aging-US

Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated aging

(2016) Alexandra Dallaire et al.   Aging-US

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance

(2014) R Cui et al.   GENE THERAPY

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

(2014) Bogna Grygiel-Górniak   Nutrition Journal

Nutrient control of Drosophila longevity

(2014) Marc Tatar et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3–FOXO1 signaling pathway

(2013) Bin Zhang et al.   AGE

FGT-1 is the major glucose transporter inC. elegansand is central to aging pathways

(2013) Ying Feng et al.   BIOCHEMICAL JOURNAL

Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR

(2013) Jordan Gallinetti et al.   BIOCHEMICAL JOURNAL

Deleterious consequences of antioxidant supplementation on lifespan in a wild-derived mammal

(2013) C. Selman et al.   Biology Letters

Sulfur Amino Acids Regulate Translational Capacity and Metabolic Homeostasis through Modulation of tRNA Thiolation

(2013) Sunil Laxman et al.   CELL

Methionine Inhibits Autophagy and Promotes Growth by Inducing the SAM-Responsive Methylation of PP2A

(2013) Benjamin M. Sutter et al.   CELL

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

(2013) Filipe Cabreiro et al.   CELL

High carbohydrate–low protein consumption maximizes Drosophila lifespan

(2013) Kimberley D. Bruce et al.   EXPERIMENTAL GERONTOLOGY

 -6 Polyunsaturated fatty acids extend life span through the activation of autophagy

(2013) E. J. O'Rourke et al.   GENES & DEVELOPMENT

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide

(2013) Kathrin Schmeisser et al.   Nature Chemical Biology

High Glucose Induced Alteration of SIRTs in Endothelial Cells Causes Rapid Aging in a p300 and FOXO Regulated Pathway

(2013) Rokhsana Mortuza et al.   PLoS One

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Malate and Fumarate Extend Lifespan in Caenorhabditis elegans

(2013) Clare B. Edwards et al.   PLoS One

FGT-1 Is a Mammalian GLUT2-Like Facilitative Glucose Transporter in Caenorhabditis elegans Whose Malfunction Induces Fat Accumulation in Intestinal Cells

(2013) Shun Kitaoka et al.   PLoS One

Novel insights into ChREBP regulation and function

(2013) Gaëlle Filhoulaud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Effect of Vitamin A Supplementation on Biochemical Parameters in Multiple Sclerosis Patients

(2013) Sima Jafarirad et al.   Iranian Red Crescent Medical Journal

Interactive effects of sex, social environment, dietary restriction, and methionine on survival and reproduction in fruit flies

(2012) Felix Zajitschek et al.   AGE

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria

(2012) Inés Sanchez-Roman et al.   BIOGERONTOLOGY

Anti-Aging Effects of Hesperidin onSaccharomyces cerevisiaeviaInhibition of Reactive Oxygen Species andUTH1Gene Expression

(2012) Kaiyue SUN et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model

(2012) Bhupinder Virk et al.   BMC BIOLOGY

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Macronutrient intake and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition

(2012) Naomi E. Allen et al.   INTERNATIONAL JOURNAL OF CANCER

Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

(2012) Julie A. Mattison et al.   NATURE

Surgical Stress Resistance Induced by Single Amino Acid Deprivation Requires Gcn2 in Mice

(2012) W. Peng et al.   Science Translational Medicine

Minocycline increases the life span and motor activity and decreases lipid peroxidation in manganese treated Drosophila melanogaster

(2012) E. Bonilla et al.   TOXICOLOGY

The effect of trehalose on the fermentation performance of aged cells of Saccharomyces cerevisiae

(2011) Eduardo T. V. Trevisol et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Dietary Restriction and Aging: A Unifying Perspective

(2011) Matthew D.W. Piper et al.   Cell Metabolism

Niacin-bound chromium increases life span in Zucker Fatty Rats

(2011) Harry G. Preuss et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

High glucose diets shorten lifespan ofCaenorhabditis elegansvia ectopic apoptosis induction

(2011) Shin Sik Choi   Nutrition Research and Practice

Reactive Oxygen Species Scavenging by Catalase Is Important for Female Lutzomyia longipalpis Fecundity and Mortality

(2011) Hector Diaz-Albiter et al.   PLoS One

SREBPs: metabolic integrators in physiology and metabolism

(2011) Tae-Il Jeon et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SRT1720 improves survival and healthspan of obese mice

(2011) Robin K. Minor et al.   Scientific Reports

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

Trehalose extends longevity in the nematode Caenorhabditis elegans

(2010) Yoko Honda et al.   AGING CELL

Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease

(2010) Patty W Siri-Tarino et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging

(2010) Laurent Mouchiroud et al.   BIOFACTORS

Plant and animal protein intake and its association with overweight and obesity among the Belgian population

(2010) Yi Lin et al.   BRITISH JOURNAL OF NUTRITION

New Strategies in Prostate Cancer: Targeting Lipogenic Pathways and the Energy Sensor AMPK

(2010) G. Zadra et al.   CLINICAL CANCER RESEARCH

Inhibition of Respiration Extends C. elegans Life Span via Reactive Oxygen Species that Increase HIF-1 Activity

(2010) Seung-Jae Lee et al.   CURRENT BIOLOGY

Metabolism and longevity: Is there a role for membrane fatty acids?

(2010) A. J. Hulbert   INTEGRATIVE AND COMPARATIVE BIOLOGY

SRT1720, SRT2183, SRT1460, and Resveratrol Are Not Direct Activators of SIRT1

(2010) Michelle Pacholec et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genetics of ageing

(2010) Cynthia J. Kenyon   NATURE

A Mitochondrial Superoxide Signal Triggers Increased Longevity in Caenorhabditis elegans

(2010) Wen Yang et al.   PLOS BIOLOGY

Nutrients, not caloric restriction, extend lifespan in Queensland fruit flies (Bactrocera tryoni)

(2009) Benjamin G. Fanson et al.   AGING CELL

Vitamin K, an example of triage theory: is micronutrient inadequacy linked to diseases of aging?

(2009) Joyce C McCann et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sirtuins regulate key aspects of lipid metabolism

(2009) David J. Lomb et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1

(2009) Tanja Heidler et al.   BIOGERONTOLOGY

Phenotypic and Behavioral Defects Induced by Iron Exposure Can Be Transferred to Progeny in Caenorhabditis elegans

(2009) Ya-Ou HU et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Glucose Shortens the Life Span of C. elegans by Downregulating DAF-16/FOXO Activity and Aquaporin Gene Expression

(2009) Seung-Jae Lee et al.   Cell Metabolism

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

Life-Span Extension in Mice by Preweaning Food Restriction and by Methionine Restriction in Middle Age

(2009) L. Sun et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Amino-acid imbalance explains extension of lifespan by dietary restriction in Drosophila

(2009) Richard C. Grandison et al.   NATURE

Antioxidants prevent health-promoting effects of physical exercise in humans

(2009) M. Ristow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast

(2009) Antoine E. Roux et al.   PLoS Genetics

Longevityfertility trade-offs in the tephritid fruit fly,Anastrepha ludens, across dietary-restriction gradients

(2008) James R. Carey et al.   AGING CELL

Dietary composition specifies consumption, obesity, and lifespan inDrosophila melanogaster

(2008) Danielle A. Skorupa et al.   AGING CELL

Effect of 40% restriction of dietary amino acids (except methionine) on mitochondrial oxidative stress and biogenesis, AIF and SIRT1 in rat liver

(2008) Pilar Caro et al.   BIOGERONTOLOGY

Opposing Effects of Dietary Protein and Sugar Regulate a Transcriptional Target of Drosophila Insulin-like Peptide Signaling

(2008) Susanne Buch et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation

(2008) Jérôme N. Feige et al.   Cell Metabolism

Sex-Specific Fitness Effects of Nutrient Intake on Reproduction and Lifespan

(2008) Alexei A. Maklakov et al.   CURRENT BIOLOGY

The exceptional longevity of an egg-laying mammal, the short-beaked echidna (Tachyglossus aculeatus) is associated with peroxidation-resistant membrane composition

(2008) A.J. Hulbert et al.   EXPERIMENTAL GERONTOLOGY

Could glucose be a proaging factor?

(2008) Eva Kassi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The low-methionine content of vegan diets may make methionine restriction feasible as a life extension strategy

(2008) Mark F. McCarty et al.   MEDICAL HYPOTHESES

Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity

(2008) Sepehr Bahadorani et al.   NEUROBIOLOGY OF AGING

Utility of Caenorhabditis elegans in high throughput neurotoxicological research

(2008) Kirsten J. Helmcke et al.   NEUROTOXICOLOGY AND TERATOLOGY

Lifespan and reproduction in Drosophila: New insights from nutritional geometry

(2008) K. P. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fats and prevention of type 2 diabetes

(2008) U RISERUS et al.   PROGRESS IN LIPID RESEARCH

Folic acid and polyunsaturated fatty acids improve cognitive function and prevent depression, dementia, and Alzheimer's disease—But how and why?

(2007) Undurti N. Das   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Fatty Acid Profile of Erythrocyte Membranes As Possible Biomarker of Longevity

(2007) Annibale A. Puca et al.   REJUVENATION RESEARCH