De novo NAD+ synthesis enhances mitochondrial function and improves health

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

(2018) Ling Liu et al.   Cell Metabolism

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis

(2018) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Uridine monophosphate synthetase enables eukaryoticde novoNAD+biosynthesis from quinolinic acid

(2017) Melanie R. McReynolds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD Deficiency, Congenital Malformations, and Niacin Supplementation

(2017) Hongjun Shi et al.   NEW ENGLAND JOURNAL OF MEDICINE

NAD + metabolism: Bioenergetics, signaling and manipulation for therapy

(2016) Yue Yang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

A Genome-Scale Database and Reconstruction of Caenorhabditis elegans Metabolism

(2016) Juliane Gebauer et al.   Cell Systems

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice

(2015) Karim Gariani et al.   HEPATOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)

(2014) Pooja Jha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Novel assay for simultaneous measurement of pyridine mononucleotides synthesizing activities allows dissection of the NAD+biosynthetic machinery in mammalian cells

(2014) Federica Zamporlini et al.   FEBS Journal

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

(2013) Laurent Mouchiroud et al.   CELL

Raising awareness of acute kidney injury: a global perspective of a silent killer

(2013) Andrew J.P. Lewington et al.   KIDNEY INTERNATIONAL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

NAFLD, NASH and liver cancer

(2013) Gregory A. Michelotti et al.   Nature Reviews Gastroenterology & Hepatology

LRH-1–dependent glucose sensing determines intermediary metabolism in liver

(2012) Maaike H. Oosterveer et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Caenorhabditis elegans lifespan by sir-2.1 transgenes

(2011) Mohan Viswanathan et al.   NATURE

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

(2011) Camilla Burnett et al.   NATURE

Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans

(2010) Laurent Mouchiroud et al.   AGING CELL

The Matrix Peptide Exporter HAF-1 Signals a Mitochondrial UPR by Activating the Transcription Factor ZC376.7 in C. elegans

(2010) Cole M. Haynes et al.   MOLECULAR CELL

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

(2009) Teppei Hashimoto et al.   BIOGERONTOLOGY

Nicotinamidase modulation of NAD+ biosynthesis and nicotinamide levels separately affect reproductive development and cell survival in C. elegans

(2009) T. L. Vrablik et al.   DEVELOPMENT

Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats

(2009) Daniel Schock-Kusch et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION