Mitochondria orchestrate proteostatic and metabolic stress responses

Cross-organelle communication at the core of longevity

(2018) Nuno Raimundo et al.   Aging-US

Mitochondrial Translation Efficiency Controls Cytoplasmic Protein Homeostasis

(2018) Tamara Suhm et al.   Cell Metabolism

UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

(2018) Andrew Melber et al.   CELL RESEARCH

A Futile Battle? Protein Quality Control and the Stress of Aging

(2018) Ryo Higuchi-Sanabria et al.   DEVELOPMENTAL CELL

Cellular Handling of Protein Aggregates by Disaggregation Machines

(2018) Axel Mogk et al.   MOLECULAR CELL

MitoCPR—A surveillance pathway that protects mitochondria in response to protein import stress

(2018) Hilla Weidberg et al.   SCIENCE

Defining the physiological role of SRP in protein-targeting efficiency and specificity

(2018) Elizabeth A. Costa et al.   SCIENCE

Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response

(2018) Joanna Krakowiak et al.   eLife

The different axes of the mammalian mitochondrial unfolded protein response

(2018) Christian Münch   BMC BIOLOGY

A constitutive active allele of the transcription factor Msn2 mimicking low PKA activity dictates metabolic remodeling in yeast

(2018) Vera Pfanzagl et al.   MOLECULAR BIOLOGY OF THE CELL

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins

(2018) Günter Kramer et al.   Annual Review of Biochemistry

How and why do toxic conformers of aberrant proteins accumulate during ageing?

(2017) Rebecca Josefson et al.   Essays in Biochemistry

Proteinopathies and OXPHOS dysfunction in neurodegenerative diseases

(2017) Hibiki Kawamata et al.   JOURNAL OF CELL BIOLOGY

Coordinated Hsp110 and Hsp104 Activities Power Protein Disaggregation in Saccharomyces cerevisiae

(2017) Jayasankar Mohanakrishnan Kaimal et al.   MOLECULAR AND CELLULAR BIOLOGY

Cytosolic proteostasis through importing of misfolded proteins into mitochondria

(2017) Linhao Ruan et al.   NATURE

Light-sensing via hydrogen peroxide and a peroxiredoxin

(2017) Kristofer Bodvard et al.   Nature Communications

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging

(2017) Johnathan Labbadia et al.   Cell Reports

Msn2/4 regulate expression of glycolytic enzymes and control transition from quiescence to growth

(2017) Zheng Kuang et al.   eLife

Organization and Regulation of Mitochondrial Protein Synthesis

(2016) Martin Ott et al.   Annual Review of Biochemistry

Ground control to major TOM: mitochondria-nucleus communication

(2016) Michal Eisenberg-Bord et al.   FEBS Journal

Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis

(2016) Eric J. Solís et al.   MOLECULAR CELL

Synchronized mitochondrial and cytosolic translation programs

(2016) Mary T. Couvillion et al.   NATURE

Crosstalk between cellular compartments protects against proteotoxicity and extends lifespan

(2016) Matea Perić et al.   Scientific Reports

Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation

(2016) Agnieszka Kłosowska et al.   eLife

The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1

(2016) Gino Heeren et al.   Aging-US

The Biology of Proteostasis in Aging and Disease

(2015) Johnathan Labbadia et al.   Annual Review of Biochemistry

Rate control in yeast protein synthesis at the population and single-cell levels

(2015) E. Dacheux et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial ClpX Activates a Key Enzyme for Heme Biosynthesis and Erythropoiesis

(2015) Julia R. Kardon et al.   CELL

Quality control of mitochondrial protein synthesis is required for membrane integrity and cell fitness

(2015) Uwe Richter et al.   JOURNAL OF CELL BIOLOGY

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death

(2015) Xiaowen Wang et al.   NATURE

Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol

(2015) Lidia Wrobel et al.   NATURE

The principle of antagonism ensures protein targeting specificity at the endoplasmic reticulum

(2015) M. Gamerdinger et al.   SCIENCE

Organelle-Based Aggregation and Retention of Damaged Proteins in Asymmetrically Dividing Cells

(2014) Chuankai Zhou et al.   CELL

Activation of the mitochondrial signaling pathway in response to organic solvent stress in yeast

(2014) Nao Nishida-Aoki et al.   CURRENT GENETICS

The many ways to age for a single yeast cell

(2014) Didac Carmona-Gutierrez et al.   YEAST

Rewiring AMPK and Mitochondrial Retrograde Signaling for Metabolic Control of Aging and Histone Acetylation in Respiratory-Defective Cells

(2014) R. Magnus N. Friis et al.   Cell Reports

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

The role of mitochondria in aging

(2013) Ana Bratic et al.   JOURNAL OF CLINICAL INVESTIGATION

Prion Protein Accumulation in Lipid Rafts of Mouse Aging Brain

(2013) Federica Agostini et al.   PLoS One

Aging Yeast Cells Undergo a Sharp Entry into Senescence Unrelated to the Loss of Mitochondrial Membrane Potential

(2013) Steffen Fehrmann et al.   Cell Reports

Adenosine Triphosphate (ATP) Is a Candidate Signaling Molecule in the Mitochondria-to-Nucleus Retrograde Response Pathway

(2013) Feng Zhang et al.   Genes

Low level genome mistranslations deregulate the transcriptome and translatome and generate proteotoxic stress in yeast

(2012) João A Paredes et al.   BMC BIOLOGY

Yeast Protein Phosphatase 2A-Cdc55 Regulates the Transcriptional Response to Hyperosmolarity Stress by Regulating Msn2 and Msn4 Chromatin Recruitment

(2012) W. Reiter et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

ClpXP, an ATP-powered unfolding and protein-degradation machine

(2011) Tania A. Baker et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Absence of Mitochondrial Translation Control Proteins Extends Life Span by Activating Sirtuin-Dependent Silencing

(2011) Antonio Caballero et al.   MOLECULAR CELL

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Aging as an Event of Proteostasis Collapse

(2011) R. C. Taylor et al.   Cold Spring Harbor Perspectives in Biology

The role of lipid rafts in prion protein biology

(2010) Victoria Lewis   Frontiers in Bioscience-Landmark

The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

(2010) Sandeep K Sharma et al.   Nature Chemical Biology

Aup1-mediated Regulation of Rtg3 during Mitophagy

(2009) Dikla Journo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial protein homeostasis: the cooperative roles of chaperones and proteases

(2009) Wolfgang Voos   RESEARCH IN MICROBIOLOGY

Multiple pathways of mitochondrial-nuclear communication in yeast: Intergenomic signaling involves ABF1 and affects a different set of genes than retrograde regulation

(2008) Dong Kyun Woo et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Yeast Life Span Extension by Depletion of 60S Ribosomal Subunits Is Mediated by Gcn4

(2008) Kristan K. Steffen et al.   CELL

Life Span Extension by Calorie Restriction Depends on Rim15 and Transcription Factors Downstream of Ras/PKA, Tor, and Sch9

(2008) Min Wei et al.   PLoS Genetics

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE