Transition of acute kidney injury to chronic kidney disease: role of metabolic reprogramming

Molecular mechanisms and physiological functions of mitophagy

(2021) Mashun Onishi et al.   EMBO JOURNAL

AMPK/mTOR Signaling in Autophagy Regulation During Cisplatin-Induced Acute Kidney Injury

(2021) Ying Wang et al.   Frontiers in Physiology

Lipidomics Provides New Insight into Pathogenesis and Therapeutic Targets of the Ischemia—Reperfusion Injury

(2021) Zoran Todorović et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Renal tubule Cpt1a overexpression protects from kidney fibrosis by restoring mitochondrial homeostasis

(2021) Verónica Miguel et al.   JOURNAL OF CLINICAL INVESTIGATION

Evolving concepts in NAD+ metabolism

(2021) Claudia C.S. Chini et al.   Cell Metabolism

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

(2021) Yan Jia et al.   Frontiers in Physiology

The role of metabolic reprogramming in tubular epithelial cells during the progression of acute kidney injury

(2021) Zhenzhen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitoquinone Protects Podocytes from Angiotensin II-Induced Mitochondrial Dysfunction and Injury via the Keap1-Nrf2 Signaling Pathway

(2021) Zijing Zhu et al.   Oxidative Medicine and Cellular Longevity

Selective Wnt/β-Catenin Pathway Activation Concomitant With Sustained Overexpression of miR-21 is Responsible for Aristolochic Acid-Induced AKI-to-CKD Transition

(2021) Qing Kuang et al.   Frontiers in Pharmacology

Targeting fatty acid metabolism for fibrotic disorders

(2021) Seonghwan Hwang et al.   ARCHIVES OF PHARMACAL RESEARCH

Loss of proximal tubular transcription factor Krüppel-like factor 15 exacerbates kidney injury through loss of fatty acid oxidation

(2021) Sian E. Piret et al.   KIDNEY INTERNATIONAL

Dephosphorylation of AMP-activated protein kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction

(2021) Haijian Ma et al.   KIDNEY INTERNATIONAL

Lipidomic approaches to dissect dysregulated lipid metabolism in kidney disease

(2021) Judy Baek et al.   Nature Reviews Nephrology

Contribution of Oxidative Stress to HIF-1-Mediated Profibrotic Changes during the Kidney Damage

(2021) Hong Zhang et al.   Oxidative Medicine and Cellular Longevity

Tubular Cell Glucose Metabolism Shift During Acute and Chronic Injuries

(2021) Anna Faivre et al.   Frontiers in Medicine

AKAP1 mediates high glucose‐induced mitochondrial fission through the phosphorylation of Drp1 in podocytes

(2020) Zhaowei Chen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lactate as a fulcrum of metabolism

(2020) George A. Brooks   Redox Biology

The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

(2020) Miguel Fontecha-Barriuso et al.   Biomolecules

Acute kidney injury and maladaptive tubular repair leading to renal fibrosis

(2020) Samuel M.-W. Yu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness

(2020) Kui Jin et al.   FASEB JOURNAL

Post-Ischemic Renal Fibrosis Progression Is Halted by Delayed Contralateral Nephrectomy: The Involvement of Macrophage Activation

(2020) Pál Tod et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondrial biogenesis: An update

(2020) Lucia‐Doina Popov   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Tuberous sclerosis 1(Tsc1) mediated mTORC1 activation promotes glycolysis in tubular epithelial cells in kidney fibrosis.

(2020) Hongdi Cao et al.   KIDNEY INTERNATIONAL

A kinome-wide screen identifies a CDKL5-SOX9 regulatory axis in epithelial cell death and kidney injury

(2020) Ji Young Kim et al.   Nature Communications

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

(2020) Yongxing Lai et al.   Redox Biology

Chronic impairment of mitochondrial bioenergetics and β-oxidation promotes experimental AKI-to-CKD transition induced by folic acid

(2020) Omar Emiliano Aparicio-Trejo et al.   FREE RADICAL BIOLOGY AND MEDICINE

AKI: an increasingly recognized risk factor for CKD development and progression

(2020) J. T. Kurzhagen et al.   JOURNAL OF NEPHROLOGY

Single-Cell Transcriptome Profiling of the Kidney Glomerulus Identifies Key Cell Types and Reactions to Injury

(2020) Jun-Jae Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury

(2020) Lara Console et al.   Frontiers in Physiology

Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease

(2020) Zhenying Zuo et al.   Frontiers in Physiology

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury

(2020) Zong-Jie Fu et al.   Redox Biology

Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology

(2020) S. J. Kierans et al.   JOURNAL OF PHYSIOLOGY-LONDON

Upregulation of miR-382 contributes to renal fibrosis secondary to aristolochic acid-induced kidney injury via PTEN signaling pathway

(2020) Xiaoyan Wang et al.   Cell Death & Disease

The complex interplay between kidney injury and inflammation

(2020) Stephen J McWilliam et al.   Clinical Kidney Journal

Berberine alleviates cisplatin-induced acute kidney injury by regulating mitophagy via PINK 1/Parkin pathway

(2020) Jieying Qi et al.   Translational Andrology and Urology

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy

(2020) Qisheng Lin et al.   Autophagy

Targeting Energy Pathways in Kidney Disease: The Roles of Sirtuins, AMPK, and PGC1α

(2020) Amanda J. Clark et al.   KIDNEY INTERNATIONAL

NAD+ metabolism and its roles in cellular processes during ageing

(2020) Anthony J. Covarrubias et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial quality control in kidney injury and repair

(2020) Chengyuan Tang et al.   Nature Reviews Nephrology

Renal gluconeogenesis: an underestimated role of the kidney in systemic glucose metabolism

(2020) David Legouis et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mitochondrial proteins: from biogenesis to functional networks

(2019) Nikolaus Pfanner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hypoxia and Hypoxia-Inducible Factors in Kidney Injury and Repair

(2019) Shaoqun Shu et al.   Cells

Cancer Metabolism Drives a Stromal Regenerative Response

(2019) Simon Schwörer et al.   Cell Metabolism

Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation

(2019) Meiling Zheng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

(2019) Miguel Fontecha‐Barriuso et al.   JOURNAL OF PATHOLOGY

ACMSD: A Novel Target for Modulating NAD+ Homeostasis

(2019) Jun Yoshino   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Increased mitochondrial fission of glomerular podocytes in diabetic nephropathy

(2019) Yiqiong Ma et al.   Endocrine Connections

What Makes the Kidney Susceptible to Hypoxia?

(2019) Roger G. Evans et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Proximal tubule cyclophilin D regulates fatty acid oxidation in cisplatin-induced acute kidney injury

(2019) Hee-Seong Jang et al.   KIDNEY INTERNATIONAL

Activation of BNIP3-mediated mitophagy protects against renal ischemia–reperfusion injury

(2019) Chengyuan Tang et al.   Cell Death & Disease

GSK3β-mediated Keap1-independent regulation of Nrf2 antioxidant response: A molecular rheostat of acute kidney injury to chronic kidney disease transition

(2019) Minglei Lu et al.   Redox Biology

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Molecular Mechanisms of the Acute Kidney Injury to Chronic Kidney Disease Transition: An Updated View

(2019) Francesco Guzzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sirt6 attenuates hypoxia‐induced tubular epithelial cell injury via targeting G2/M phase arrest

(2019) Zhao Gao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Acute kidney injury

(2019) Claudio Ronco et al.   LANCET

NAD+ homeostasis in renal health and disease

(2019) Kenneth M. Ralto et al.   Nature Reviews Nephrology

Role of Renal Hypoxia in the Progression From Acute Kidney Injury to Chronic Kidney Disease

(2019) Md Mahbub Ullah et al.   SEMINARS IN NEPHROLOGY

Lithium targeting of AMPK protects against cisplatin-induced acute kidney injury by enhancing autophagy in renal proximal tubular epithelial cells

(2019) Hui Bao et al.   FASEB JOURNAL

Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

(2018) Linchong Sun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

α-Amino-β-carboxymuconate-ε-semialdehyde Decarboxylase (ACMSD) Inhibitors as Novel Modulators of De Novo Nicotinamide Adenine Dinucleotide (NAD+) Biosynthesis

(2018) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Impairment of PPARαand the Fatty Acid Oxidation Pathway Aggravates Renal Fibrosis during Aging

(2018) Ki Wung Chung et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

Global epidemiology and outcomes of acute kidney injury

(2018) Eric A. J. Hoste et al.   Nature Reviews Nephrology

Long-term risk of adverse outcomes after acute kidney injury: a systematic review and meta-analysis of cohort studies using consensus definitions of exposure

(2018) Emily J. See et al.   KIDNEY INTERNATIONAL

Metabolic reprogramming by the S-nitroso-CoA reductase system protects against kidney injury

(2018) Hua-Lin Zhou et al.   NATURE

De novo NAD+ synthesis enhances mitochondrial function and improves health

(2018) Elena Katsyuba et al.   NATURE

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dynamin-Related Protein 1 Deficiency Promotes Recovery from AKI

(2017) Heather M. Perry et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1α-Foxo1 Signaling in Mice

(2017) Yu Ah Hong et al.   KIDNEY & BLOOD PRESSURE RESEARCH

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Metabolic reprogramming and tolerance during sepsis-induced AKI

(2017) Hernando Gómez et al.   Nature Reviews Nephrology

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Structural basis for the phosphorylation of FUNDC1 LIR as a molecular switch of mitophagy

(2016) Yao Kuang et al.   Autophagy

Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI

(2016) R. Lan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protein Kinase C δ Suppresses Autophagy to Induce Kidney Cell Apoptosis in Cisplatin Nephrotoxicity

(2016) Dongshan Zhang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Protection of mitochondria prevents high-fat diet–induced glomerulopathy and proximal tubular injury

(2016) Hazel H. Szeto et al.   KIDNEY INTERNATIONAL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

SIRT1/3 Activation by Resveratrol Attenuates Acute Kidney Injury in a Septic Rat Model

(2016) Siqi Xu et al.   Oxidative Medicine and Cellular Longevity

The Role of Acute Kidney Injury in Chronic Kidney Disease

(2016) Raymond K. Hsu et al.   SEMINARS IN NEPHROLOGY

PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation

(2016) Min Xie et al.   Nature Communications

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Sustained Activation of Wnt/ -Catenin Signaling Drives AKI to CKD Progression

(2015) L. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Snail1-induced partial epithelial-to-mesenchymal transition drives renal fibrosis in mice and can be targeted to reverse established disease

(2015) M Teresa Grande et al.   NATURE MEDICINE

Protection against renal ischemia–reperfusion injury in vivo by the mitochondria targeted antioxidant MitoQ

(2015) Anna J. Dare et al.   Redox Biology

Renal Cortical Pyruvate Depletion during AKI

(2014) R. A. Zager et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Beyond Tissue Injury--Damage-Associated Molecular Patterns, Toll-Like Receptors, and Inflammasomes Also Drive Regeneration and Fibrosis

(2014) H.-J. Anders et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Interaction between systemic inflammation and renal tubular epithelial cells

(2014) Vincenzo Cantaluppi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: a systematic review

(2014) Jason H Greenberg et al.   BMC Nephrology

PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis

(2014) Liangchun Yang et al.   Nature Communications

The Mitochondrial-Targeted Compound SS-31 Re-Energizes Ischemic Mitochondria by Interacting with Cardiolipin

(2013) A. V. Birk et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Macrophage Phenotype Controls Long-Term AKI Outcomes--Kidney Regeneration versus Atrophy

(2013) M. Lech et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Association of Complete Recovery From Acute Kidney Injury With Incident CKD Stage 3 and All-Cause Mortality

(2012) Jason Jones et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Does AKI Truly Lead to CKD?

(2012) D. E. Rifkin et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia Inducible Factor 1-Alpha (HIF-1 Alpha) Is Induced during Reperfusion after Renal Ischemia and Is Critical for Proximal Tubule Cell Survival

(2012) Elisa Conde et al.   PLoS One

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fenofibrate, a PPARα agonist, has renoprotective effects in mice by enhancing renal lipolysis

(2011) Yuki Tanaka et al.   KIDNEY INTERNATIONAL

Increased risk of death and de novo chronic kidney disease following reversible acute kidney injury

(2011) Ion D. Bucaloiu et al.   KIDNEY INTERNATIONAL

Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis

(2011) Steven G. Coca et al.   KIDNEY INTERNATIONAL

POST-TREATMENT With the Combination of 5-Aminoimidazole-4-Carboxyamide Ribonucleoside and Carnitine Improves Renal Function After Ischemia/Reperfusion Injury

(2011) Juan-Pablo Idrovo et al.   SHOCK

Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARα deterioration

(2011) Kyoko Takahashi et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Oleate and eicosapentaenoic acid attenuate palmitate-induced inflammation and apoptosis in renal proximal tubular cell

(2010) Mariko Soumura et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lipotoxicity in renal proximal tubular cells: Relationship between endoplasmic reticulum stress and oxidative stress pathways

(2010) Elias Katsoulieris et al.   FREE RADICAL BIOLOGY AND MEDICINE

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

(2010) Ji-Hong Lim et al.   MOLECULAR CELL

Long-term Risk of Mortality and Other Adverse Outcomes After Acute Kidney Injury: A Systematic Review and Meta-analysis

(2009) Steven G. Coca et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION