PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
Published 2014 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis
Authors
Keywords
-
Journal
Nature Communications
Volume 5, Issue 1, Pages -
Publisher
Springer Nature
Online
2014-07-16
DOI
10.1038/ncomms5436
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis
- (2013) Minghua Yang et al. BIOCHEMICAL PHARMACOLOGY
- Protective Role of Oligomycin Against Intestinal Epithelial Barrier Dysfunction Caused by IFN-? and TNF-a
- (2013) Hang Liu et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Beneficial Effect of Shikonin on Experimental Colitis Induced by Dextran Sulfate Sodium in Balb/C Mice
- (2013) Isabel Andújar et al. Evidence-based Complementary and Alternative Medicine
- Metabolism of inflammation limited by AMPK and pseudo-starvation
- (2013) Luke A. J. O'Neill et al. NATURE
- Succinate is an inflammatory signal that induces IL-1β through HIF-1α
- (2013) G. M. Tannahill et al. NATURE
- Severe Sepsis and Septic Shock
- (2013) Derek C. Angus et al. NEW ENGLAND JOURNAL OF MEDICINE
- Pharmacological Properties of Shikonin – A Review of Literature since 2002
- (2013) Isabel Andújar et al. PLANTA MEDICA
- Prognostic Significance of Blood Lactate and Lactate Clearance in Trauma Patients
- (2012) Marie-Alix Régnier et al. ANESTHESIOLOGY
- Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells
- (2012) B. Everts et al. BLOOD
- Orchestration of Metabolism by Macrophages
- (2012) Subhra K. Biswas et al. Cell Metabolism
- EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes Tumorigenesis
- (2012) Weiwei Yang et al. MOLECULAR CELL
- ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
- (2012) Weiwei Yang et al. NATURE CELL BIOLOGY
- A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?
- (2012) Haitao Wen et al. NATURE IMMUNOLOGY
- Metabolic checkpoints in activated T cells
- (2012) Ruoning Wang et al. NATURE IMMUNOLOGY
- Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression
- (2012) Tom Latham et al. NUCLEIC ACIDS RESEARCH
- The high mobility group box: the ultimate utility player of a cell
- (2012) Christopher S. Malarkey et al. TRENDS IN BIOCHEMICAL SCIENCES
- Emerging roles of PKM2 in cell metabolism and cancer progression
- (2012) Weibo Luo et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Targeting Hypoxia-induced Inflammation
- (2011) Holger K. Eltzschig ANESTHESIOLOGY
- HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection
- (2011) Ulf Andersson et al. Annual Review of Immunology
- Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1
- (2011) Weibo Luo et al. CELL
- Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
- (2011) Eric V. Dang et al. CELL
- High-Mobility Group Box 1 Is Essential for Mitochondrial Quality Control
- (2011) Daolin Tang et al. Cell Metabolism
- HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells
- (2011) Lewis Z. Shi et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Theoretical investigation of the radical scavenging activity of shikonin and acylshikonin derivatives
- (2011) Ruifa Jin et al. JOURNAL OF MOLECULAR MODELING
- Hypoxia and Inflammation
- (2011) NEW ENGLAND JOURNAL OF MEDICINE
- Shikonin and its analogs inhibit cancer cell glycolysis by targeting tumor pyruvate kinase-M2
- (2011) J Chen et al. ONCOGENE
- Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation
- (2010) C. M. Krawczyk et al. BLOOD
- High Mobility Group Box 1 Release from Hepatocytes during Ischemia and Reperfusion Injury Is Mediated by Decreased Histone Deacetylase Activity
- (2010) John Evankovich et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Endogenous HMGB1 regulates autophagy
- (2010) Daolin Tang et al. JOURNAL OF CELL BIOLOGY
- A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
- (2010) H. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of hyperglycemia and insulin therapy on high mobility group box 1 in endotoxin-induced acute lung injury in a rat model*
- (2009) Satoshi Hagiwara et al. CRITICAL CARE MEDICINE
- International Study of the Prevalence and Outcomes of Infection in Intensive Care Units
- (2009) Jean-Louis Vincent JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Lactate Boosts TLR4 Signaling and NF- B Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation
- (2009) D. J. Samuvel et al. JOURNAL OF IMMUNOLOGY
- WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells
- (2009) R Kang et al. LEUKEMIA
- Hypoxia inducible factor-1α induction by tumour necrosis factor-α, but not by toll-like receptor agonists, modulates cellular respiration in cultured human hepatocytes
- (2009) Tomas Regueira et al. LIVER INTERNATIONAL
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
- (2009) T. Hitosugi et al. Science Signaling
- LPS Induces Hypoxia-Inducible Factor 1 Activation in Macrophage-Differentiated Cells in a Reactive Oxygen Species–Dependent Manner
- (2008) Kenichiro Nishi et al. ANTIOXIDANTS & REDOX SIGNALING
- Role of GPR81 in lactate-mediated reduction of adipose lipolysis
- (2008) Tian-Quan Cai et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cancer Cell Metabolism: Warburg and Beyond
- (2008) Peggy P. Hsu et al. CELL
- The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
- (2008) Heather R. Christofk et al. NATURE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now