Activation of AMP‐activated protein kinase during sepsis/inflammation improves survival by preserving cellular metabolic fitness

Activation of AMPK-SIRT3 Signaling is Chondroprotective by Preserving Mitochondrial DNA Integrity and Function

(2018) Liang-Yu Chen et al.   OSTEOARTHRITIS AND CARTILAGE

Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis

(2017) Xianghong Zhang et al.   FASEB JOURNAL

Adenosine production by brain cells

(2017) Edwin K. Jackson et al.   JOURNAL OF NEUROCHEMISTRY

AMPK Maintains Cellular Metabolic Homeostasis through Regulation of Mitochondrial Reactive Oxygen Species

(2017) Rebecca C. Rabinovitch et al.   Cell Reports

Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells

(2017) Wei Xie et al.   MEDICAL SCIENCE MONITOR

The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock

(2016) John A. Kellum et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Permissive role of AMPK and autophagy in adiponectin deficiency-accentuated myocardial injury and inflammation in endotoxemia

(2016) Jun Ren et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

PHARMACOLOGICAL SIRT1 ACTIVATION IMPROVES MORTALITY AND MARKEDLY ALTERS TRANSCRIPTIONAL PROFILES THAT ACCOMPANY EXPERIMENTAL SEPSIS

(2016) Steven M. Opal et al.   SHOCK

Regulation of Mitochondrial Biogenesis and Its Intersection with Inflammatory Responses

(2015) Anne D. Cherry et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of the nucleotide-binding domain-like receptor protein 3 inflammasome in acute kidney injury

(2015) Yanhui Cao et al.   FEBS Journal

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

(2015) Daniel A. Escobar et al.   JOURNAL OF SURGICAL RESEARCH

High-mobility group box 1 accelerates lipopolysaccharide-induced lung fibroblast proliferation in vitro: involvement of the NF-κB signaling pathway

(2015) Wen Li et al.   LABORATORY INVESTIGATION

Metformin: An Old Drug for the Treatment of Diabetes but a New Drug for the Protection of the Endothelium

(2015) Mustafa Kinaan et al.   MEDICAL PRINCIPLES AND PRACTICE

Inhaled, nebulized sodium nitrite protects in murine and porcine experimental models of hemorrhagic shock and resuscitation by limiting mitochondrial injury

(2015) Benjamin Kautza et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Evidence of oxidative stress and mitochondrial respiratory chain dysfunction in an in vitro model of sepsis-induced kidney injury

(2014) C. Quoilin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Platelet bioenergetic screen in sickle cell patients reveals mitochondrial complex V inhibition, which contributes to platelet activation

(2014) N. Cardenes et al.   BLOOD

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanism of Inhibition of the Human Sirtuin Enzyme SIRT3 by Nicotinamide: Computational and Experimental Studies

(2014) Xiangying Guan et al.   PLoS One

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Lipopolysaccharides Reduce Adipogenesis in 3T3-L1 Adipocytes Through Activation of NF-κB Pathway and Downregulation of AMPK Expression

(2013) Lifeng Wang et al.   Cardiovascular Toxicology

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

CaMKI  Regulates AMP Kinase-Dependent, TORC-1-Independent Autophagy during Lipopolysaccharide-Induced Acute Lung Neutrophilic Inflammation

(2013) L. Guo et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

(2013) Ming Zhan et al.   KIDNEY INTERNATIONAL

Severe Sepsis and Septic Shock

(2013) Derek C. Angus et al.   NEW ENGLAND JOURNAL OF MEDICINE

Metformin Inhibits the Growth of Human Pancreatic Cancer Xenografts

(2013) Krisztina Kisfalvi et al.   PANCREAS

Gender differences in sepsis

(2013) Martin K Angele et al.   Virulence

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease

(2012) Jinrong Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomarkers of mitochondrial content in skeletal muscle of healthy young human subjects

(2012) Steen Larsen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Development of Oxidative Stress in the Peritubular Capillary Microenvironment Mediates Sepsis-Induced Renal Microcirculatory Failure and Acute Kidney Injury

(2011) Zhen Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer

(2011) D. Grahame Hardie   BIOCHEMICAL SOCIETY TRANSACTIONS

AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases

(2011) Shi-Bei Wu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cytometric assessment of mitochondria using fluorescent probes

(2011) Cécile Cottet-Rousselle et al.   CYTOMETRY PART A

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Acute kidney injury: what's the prognosis?

(2011) Raghavan Murugan et al.   Nature Reviews Nephrology

Metformin inhibits HMGB1 release in LPS-treated RAW 264.7 cells and increases survival rate of endotoxaemic mice

(2010) Konstantin Tsoyi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Interdependence of AMPK and SIRT1 for Metabolic Adaptation to Fasting and Exercise in Skeletal Muscle

(2010) Carles Cantó et al.   Cell Metabolism

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

AMPK signaling in sepsis allows for the induction of autophagy and maintenance of cellular energetic stores

(2010) Evie Carchman et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

AMP-activated protein kinase activator A-769662 is an inhibitor of the Na+-K+-ATPase

(2009) Boubacar Benziane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration

(2009) Nicolas Lerolle et al.   INTENSIVE CARE MEDICINE

Chronic Dialysis and Death Among Survivors of Acute Kidney Injury Requiring Dialysis

(2009) Ron Wald   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Carbon Monoxide Rescues Mice from Lethal Sepsis by Supporting Mitochondrial Energetic Metabolism and Activating Mitochondrial Biogenesis

(2009) S. Lancel et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Up-regulation of orphan nuclear estrogen-related receptor alpha expression during long-term caloric restriction in mice

(2009) Harmit S. Ranhotra   MOLECULAR AND CELLULAR BIOCHEMISTRY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA