The Role of PGC-1α and Mitochondrial Biogenesis in Kidney Diseases

NAFLD as a driver of chronic kidney disease

(2020) Christopher D. Byrne et al.   JOURNAL OF HEPATOLOGY

A mitochondrial-targeted peptide ameliorated podocyte apoptosis through a HOCl-alb-enhanced and mitochondria-dependent signalling pathway in diabetic rats and in vitro

(2019) Xiaoqiao Wang et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Selenium and selenoproteins: from endothelial cytoprotection to clinical outcomes

(2019) Emilio Lopes Junior et al.   Translational Research

Sepsis associated acute kidney injury

(2019) Jason T Poston et al.   BMJ-British Medical Journal

Deregulation of long noncoding RNA (TUG1) contributes to excessive podocytes apoptosis by activating endoplasmic reticulum stress in the development of diabetic nephropathy

(2019) Hongchun Shen et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys

(2019) Man J. Livingston et al.   Autophagy

PGC‐1α deficiency causes spontaneous kidney inflammation and increases the severity of nephrotoxic AKI

(2019) Miguel Fontecha‐Barriuso et al.   JOURNAL OF PATHOLOGY

Mitochondria in Sepsis-Induced AKI

(2019) Jian Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Anaerobic Glycolysis Maintains the Glomerular Filtration Barrier Independent of Mitochondrial Metabolism and Dynamics

(2019) Paul T. Brinkkoetter et al.   Cell Reports

The Notch pathway: a novel therapeutic target for cardiovascular diseases?

(2019) Giorgio Aquila et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Acute kidney injury from sepsis: current concepts, epidemiology, pathophysiology, prevention and treatment

(2019) Sadudee Peerapornratana et al.   KIDNEY INTERNATIONAL

PGRN acts as a novel regulator of mitochondrial homeostasis by facilitating mitophagy and mitochondrial biogenesis to prevent podocyte injury in diabetic nephropathy

(2019) Di Zhou et al.   Cell Death & Disease

Hypoxia-induced PGC-1α Regulates Mitochondrial Function and Tumorigenesis of Colorectal Cancer Cells

(2019) CHUL WON YUN et al.   ANTICANCER RESEARCH

Mitochondrial dysfunction in diabetic kidney disease

(2019) Pascal Zhongping Wei et al.   CLINICA CHIMICA ACTA

Loss of NLRP6 expression increases the severity of acute kidney injury

(2019) Lara Valiño-Rivas et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

MiR‐9‐5p protects from kidney fibrosis by metabolic reprogramming

(2019) Marta Fierro‐Fernández et al.   FASEB JOURNAL

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

(2019) Julia Wattacheril   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Extracellular Superoxide Dismutase Attenuates Renal Oxidative Stress Through the Activation of Adenosine Monophosphate-Activated Protein Kinase in Diabetic Nephropathy

(2018) Yu Ah Hong et al.   ANTIOXIDANTS & REDOX SIGNALING

Emerging therapies for mitochondrial diseases

(2018) Michio Hirano et al.   Essays in Biochemistry

Scutellarin ameliorates nonalcoholic fatty liver disease through the PPARγ/PGC-1α-Nrf2 pathway

(2018) Xiaoxue Zhang et al.   FREE RADICAL RESEARCH

Increased podocyte Sirtuin-1 function attenuates diabetic kidney injury

(2018) Quan Hong et al.   KIDNEY INTERNATIONAL

Targeting of regulated necrosis in kidney disease

(2018) Diego Martin-Sanchez et al.   NEFROLOGIA

Targeting epigenetic DNA and histone modifications to treat kidney disease

(2018) Miguel Fontecha-Barriuso et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

The Role of TLR4 on PGC-1α-Mediated Oxidative Stress in Tubular Cell in Diabetic Kidney Disease

(2018) Shuguang Yuan et al.   Oxidative Medicine and Cellular Longevity

TWEAK and RIPK1 mediate a second wave of cell death during AKI

(2018) Diego Martin-Sanchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

(2018) Dan Li et al.   Cell Death & Disease

Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway

(2018) Sufan Wang et al.   Redox Biology

Mitochondrial dysfunction and oxidative stress are involved in the mechanism of methotrexate-induced renal injury and electrolytes imbalance

(2018) Reza Heidari et al.   BIOMEDICINE & PHARMACOTHERAPY

Cardiorenal Syndrome Revisited

(2018) Faiez Zannad et al.   CIRCULATION

Pgc-1αrepression and high-fat diet induce age-related macular degeneration-like phenotypes in mice

(2018) Meng Zhang et al.   Disease Models & Mechanisms

Resveratrol ameliorates podocyte damage in diabetic mice via SIRT1/PGC-1α mediated attenuation of mitochondrial oxidative stress

(2018) Tao Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Obesity causes Pgc-1α deficiency in the pancreas leading to marked Il-6 up-regulation via NF-κB in acute pancreatitis

(2018) Salvador Pérez et al.   JOURNAL OF PATHOLOGY

De novo NAD+ biosynthetic impairment in acute kidney injury in humans

(2018) Ali Poyan Mehr et al.   NATURE MEDICINE

MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes

(2018) Mengistu Lemecha et al.   Scientific Reports

An overview of Sirtuins as potential therapeutic target: Structure, function and modulators

(2018) Yijie Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories

(2018) Kyle J Foreman et al.   LANCET

The Spanish Society of Nephrology (SENEFRO) commentary to the Spain GBD 2016 report: Keeping chronic kidney disease out of sight of health authorities will only magnify the problem

(2018) Alberto Ortiz et al.   NEFROLOGIA

MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells

(2018) Lara Valiño-Rivas et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

C1q/TNF-Related Protein-9 Ameliorates Ox-LDL-Induced Endothelial Dysfunction via PGC-1α/AMPK-Mediated Antioxidant Enzyme Induction

(2017) Haijian Sun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cisplatin nephrotoxicity: a review of the literature

(2017) Sandhya Manohar et al.   JOURNAL OF NEPHROLOGY

Mitochondrial biogenesis in neurodegeneration

(2017) P. Andy Li et al.   JOURNAL OF NEUROSCIENCE RESEARCH

SRT1720, a sirtuin 1 activator, attenuates organ injury and inflammation in sepsis

(2017) Adam Khader et al.   JOURNAL OF SURGICAL RESEARCH

PGC-1αProtects from Notch-Induced Kidney Fibrosis Development

(2017) Seung Hyeok Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Nicotinamide Mononucleotide, an NAD + Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

(2017) Yi Guan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FXR/TGR5 Dual Agonist Prevents Progression of Nephropathy in Diabetes and Obesity

(2017) Xiaoxin X. Wang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Obesity and kidney disease: from population to basic science and the search for new therapeutic targets

(2017) Adam Whaley-Connell et al.   KIDNEY INTERNATIONAL

Pyruvate dehydrogenase kinase 4 deficiency attenuates cisplatin-induced acute kidney injury

(2017) Chang Joo Oh et al.   KIDNEY INTERNATIONAL

The hallmarks of mitochondrial dysfunction in chronic kidney disease

(2017) Daniel L. Galvan et al.   KIDNEY INTERNATIONAL

Chronic Kidney Disease

(2017) Angela C Webster et al.   LANCET

Metabolomics reveal mitochondrial and fatty acid metabolism disorders that contribute to the development of DKD in T2DM patients

(2017) Ling Li et al.   Molecular BioSystems

Therapies for mitochondrial diseases and current clinical trials

(2017) Ayman W. El-Hattab et al.   MOLECULAR GENETICS AND METABOLISM

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

(2017) Weier Qi et al.   NATURE MEDICINE

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

The systemic nature of CKD

(2017) Carmine Zoccali et al.   Nature Reviews Nephrology

Sulfasalazine induces mitochondrial dysfunction and renal injury

(2017) Hossein Niknahad et al.   RENAL FAILURE

The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1

(2017) Li Xiao et al.   Redox Biology

Differentially expressed miRNAs in sepsis-induced acute kidney injury target oxidative stress and mitochondrial dysfunction pathways

(2017) Qin-Min Ge et al.   PLoS One

Oxidative stress induces loss of pericyte coverage and vascular instability in PGC-1α-deficient mice

(2016) Nieves García-Quintans et al.   ANGIOGENESIS

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Dysfunction of kidney endothelium after ischemia/reperfusion and its prevention by mitochondria-targeted antioxidant

(2016) S. S. Jankauskas et al.   BIOCHEMISTRY-MOSCOW

Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis

(2016) M. Honarpisheh et al.   BIOSCIENCE REPORTS

Histone lysine crotonylation during acute kidney injury in mice

(2016) Olga Ruiz-Andres et al.   Disease Models & Mechanisms

Regulation of endothelial dynamics by PGC-1α relies on ROS control of VEGF-A signaling

(2016) Nieves García-Quintans et al.   FREE RADICAL BIOLOGY AND MEDICINE

PDE5 inhibitors protect against post-infarction heart failure

(2016) Haichang Wang   Frontiers in Bioscience-Landmark

Short ischemia induces rat kidney mitochondria dysfunction

(2016) Rasa Baniene et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Rapid Renal Regulation of Peroxisome Proliferator-activated Receptor γ Coactivator-1α by Extracellular Signal-Regulated Kinase 1/2 in Physiological and Pathological Conditions

(2016) Justin B. Collier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of microRNAs on the Regulation of Mitochondrial Biogenesis and Insulin Signaling in Skeletal Muscle

(2016) Tanes I. Lima et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Long noncoding RNA Tug1 regulates mitochondrial bioenergetics in diabetic nephropathy

(2016) Jianyin Long et al.   JOURNAL OF CLINICAL INVESTIGATION

PGC-1α, glucose metabolism and type 2 diabetes mellitus

(2016) Haijiang Wu et al.   JOURNAL OF ENDOCRINOLOGY

Ferroptosis, but Not Necroptosis, Is Important in Nephrotoxic Folic Acid–Induced AKI

(2016) Diego Martin-Sanchez et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria Protection after Acute Ischemia Prevents Prolonged Upregulation of IL-1βand IL-18 and Arrests CKD

(2016) Hazel H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The inflammatory cytokine TWEAK decreases PGC-1α expression and mitochondrial function in acute kidney injury

(2016) Olga Ruiz-Andres et al.   KIDNEY INTERNATIONAL

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Comparación de los sistemas de clasificación del fracaso renal agudo en la sepsis

(2016) Emilio Rodrigo et al.   NEFROLOGIA

The Role of Acute Kidney Injury in Chronic Kidney Disease

(2016) Raymond K. Hsu et al.   SEMINARS IN NEPHROLOGY

PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria

(2016) Min Zhao et al.   Oncotarget

Clinical management of the uraemic syndrome in chronic kidney disease

(2016) Raymond Vanholder et al.   Lancet Diabetes & Endocrinology

Disruption of cytochrome c heme coordination is responsible for mitochondrial injury during ischemia

(2015) Alexander V. Birk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Mitochondrial division and fusion in metabolism

(2015) Madhuparna Roy et al.   CURRENT OPINION IN CELL BIOLOGY

New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond

(2015) Josep A. Villena   FEBS Journal

SIRT1/PGC-1α signaling protects hepatocytes against mitochondrial oxidative stress induced by bile acids

(2015) M. Tan et al.   FREE RADICAL RESEARCH

Sirtuin 3–dependent mitochondrial dynamic improvements protect against acute kidney injury

(2015) Marina Morigi et al.   JOURNAL OF CLINICAL INVESTIGATION

Leigh Syndrome

(2015) Nicole J. Lake et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression

(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Insuficiencia renal aguda relacionada con medicamentos en pacientes hospitalizados

(2015) Lujan Iavecchia et al.   NEFROLOGIA

Mitochondria: a therapeutic target in acute kidney injury

(2015) Yu Ishimoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Mitochondrial Function and Disturbances in the Septic Kidney

(2015) Samir M. Parikh et al.   SEMINARS IN NEPHROLOGY

Resveratrol Rescues Kidney Mitochondrial Function Following Hemorrhagic Shock

(2015) Hao Wang et al.   SHOCK

Molecular Profile of Mitochondrial Dysfunction in Kidney Transplant Biopsies Is Associated With Poor Allograft Outcome

(2015) D. Zepeda-Orozco et al.   TRANSPLANTATION PROCEEDINGS

PGC-1 coactivators in β-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids

(2015) Daniel Oropeza et al.   Molecular Metabolism

Mitochondrial dysregulation and protection in cisplatin nephrotoxicity

(2014) Yuan Yang et al.   ARCHIVES OF TOXICOLOGY

Mitochondrial Biogenesis: A Therapeutic Target for Neurodevelopmental Disorders and Neurodegenerative Diseases

(2014) Martine Uittenbogaard et al.   CURRENT PHARMACEUTICAL DESIGN

Mitochondria-targeted therapies for acute kidney injury

(2014) Luis Carlos Tábara et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Disruption of Renal Tubular Mitochondrial Quality Control by Myo-Inositol Oxygenase in Diabetic Kidney Disease

(2014) M. Zhan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Deficient Autophagy Results in Mitochondrial Dysfunction and FSGS

(2014) T. Kawakami et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Formoterol Restores Mitochondrial and Renal Function after Ischemia-Reperfusion Injury

(2014) S. R. Jesinkey et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endoplasmic Reticulum Stress Links Hepatitis C Virus RNA Replication to Wild-Type PGC-1 /Liver-Specific PGC-1  Upregulation

(2014) W. Yao et al.   JOURNAL OF VIROLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

TWEAK and the progression of renal disease: clinical translation

(2014) A. B. Sanz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Fenofibrate Improves Renal Lipotoxicity through Activation of AMPK-PGC-1α in db/db Mice

(2014) Yu Ah Hong et al.   PLoS One

Staphylococcus aureus Sepsis Induces Early Renal Mitochondrial DNA Repair and Mitochondrial Biogenesis in Mice

(2014) Raquel R. Bartz et al.   PLoS One

Tempol, a Superoxide Dismutase Mimetic Agent, Ameliorates Cisplatin-Induced Nephrotoxicity through Alleviation of Mitochondrial Dysfunction in Mice

(2014) Lamiaa A. Ahmed et al.   PLoS One

Targeting PGC-1α to Overcome the Harmful Effects of Glucocorticoids in Porcine Neonatal Pancreas Cell Clusters

(2014) Ji-Won Kim et al.   TRANSPLANTATION

Sirtuin 1 Activation Stimulates Mitochondrial Biogenesis and Attenuates Renal Injury After Ischemia-Reperfusion

(2014) Adam Khader et al.   TRANSPLANTATION

Caloric restriction ameliorates kidney ischaemia/reperfusion injury through PGC-1α-eNOS pathway and enhanced autophagy

(2013) J. Lempiäinen et al.   Acta Physiologica

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Rap1 Ameliorates Renal Tubular Injury in Diabetic Nephropathy

(2013) L. Xiao et al.   DIABETES

Regulatory circuitry of TWEAK-Fn14 system and PGC-1α in skeletal muscle atrophy program

(2013) Sajedah M. Hindi et al.   FASEB JOURNAL

Metabolomics Reveals Signature of Mitochondrial Dysfunction in Diabetic Kidney Disease

(2013) K. Sharma et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

(2013) Gi-Su Oh et al.   KIDNEY INTERNATIONAL

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

Oxidative Stress and Cell Senescence Combine to Cause Maximal Renal Tubular Epithelial Cell Dysfunction and Loss in an in vitro Model of Kidney Disease

(2013) David M. Small et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction

(2013) Jianru Shi et al.   PLoS One

Peroxisome Proliferator-Activated Receptor δ Agonist, HPP593, Prevents Renal Necrosis under Chronic Ischemia

(2013) Larisa V. Fedorova et al.   PLoS One

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

Mitochondrial Autophagy Involving Renal Injury and Aging Is Modulated by Caloric Intake in Aged Rat Kidneys

(2013) Jing Cui et al.   PLoS One

5-Aminolevulinic Acid Protects against Cisplatin-Induced Nephrotoxicity without Compromising the Anticancer Efficiency of Cisplatin in Rats In Vitro and In Vivo

(2013) Yoshio Terada et al.   PLoS One

Suppressed mitochondrial biogenesis in folic acid-induced acute kidney injury and early fibrosis

(2013) L. Jay Stallons et al.   TOXICOLOGY LETTERS

ERK and p38 inhibitors attenuate memory deficits and increase CREB phosphorylation and PGC-1α levels in Aβ-injected rats

(2012) Ghorbangol Ashabi et al.   BEHAVIOURAL BRAIN RESEARCH

Glucocorticoid treatment independently affects expansion and transdifferentiation of porcine neonatal pancreas cell clusters

(2012) Ji-Won Kim et al.   BMB Reports

Transgenic Control of Mitochondrial Fission Induces Mitochondrial Uncoupling and Relieves Diabetic Oxidative Stress

(2012) C. A. Galloway et al.   DIABETES

Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK–SIRT1–PGC1α axis in db/db mice

(2012) M. Y. Kim et al.   DIABETOLOGIA

Cisplatin Nephrotoxicity Involves Mitochondrial Injury with Impaired Tubular Mitochondrial Enzyme Activity

(2012) Zsuzsanna K. Zsengellér et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Activation of peroxisome proliferator-activated receptor-γ coactivator 1α ameliorates mitochondrial dysfunction and protects podocytes from aldosterone-induced injury

(2012) Yanggang Yuan et al.   KIDNEY INTERNATIONAL

The tubule pathology of septic acute kidney injury: a neglected area of research comes of age

(2012) Manjeri A. Venkatachalam et al.   KIDNEY INTERNATIONAL

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy

(2011) Partha Mukhopadhyay et al.   FREE RADICAL BIOLOGY AND MEDICINE

Characterization of Novel Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α) Isoform in Human Liver

(2011) Thomas K. Felder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria-Targeted Peptide Accelerates ATP Recovery and Reduces Ischemic Kidney Injury

(2011) H. H. Szeto et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice

(2011) Michal Aharoni-Simon et al.   LABORATORY INVESTIGATION

Granular Swollen Epithelial Cells: A Histologic and Diagnostic Marker for Mitochondrial Nephropathy

(2010) Akimitsu Kobayashi et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Prevention of diabetic nephropathy in Ins2+/−AkitaJmice by the mitochondria-targeted therapy MitoQ

(2010) Balu K. Chacko et al.   BIOCHEMICAL JOURNAL

MicroRNA-15a positively regulates insulin synthesis by inhibiting uncoupling protein-2 expression

(2010) Liang-Liang Sun et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Inactivation of Foxo3a and Subsequent Downregulation of PGC-1  Mediate Nitric Oxide-Induced Endothelial Cell Migration

(2010) S. Borniquel et al.   MOLECULAR AND CELLULAR BIOLOGY

Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis

(2010) Xingxing Kong et al.   PLoS One

Involvement of Mitochondria-Mediated Apoptosis in Ethylbenzene-Induced Renal Toxicity in Rat

(2010) Ming Zhang et al.   TOXICOLOGICAL SCIENCES

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Natriuretic Peptides/cGMP/cGMP-Dependent Protein Kinase Cascades Promote Muscle Mitochondrial Biogenesis and Prevent Obesity

(2009) Kazutoshi Miyashita et al.   DIABETES

Histopathology of septic shock induced acute kidney injury: apoptosis and leukocytic infiltration

(2009) Nicolas Lerolle et al.   INTENSIVE CARE MEDICINE

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models

(2009) Craig Brooks et al.   JOURNAL OF CLINICAL INVESTIGATION

Enhanced short-term improvement of insulin response to a low-caloric diet in obese carriers the Gly482Ser variant of the PGC-1α gene

(2008) Estibaliz Goyenechea et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion

(2008) C. Ling et al.   DIABETOLOGIA

Selenoprotein P expression is controlled through interaction of the coactivator PGC-1α with FoxO1a and hepatocyte nuclear factor 4α transcription factors

(2008) Bodo Speckmann et al.   HEPATOLOGY

Rap1b GTPase Ameliorates Glucose-Induced Mitochondrial Dysfunction

(2008) L. Sun et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Renal Apoptosis in Health and Disease

(2008) A. B. Sanz et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY