Review
Urology & Nephrology
Delal Dalga, Thomas Verissimo, Sophie de Seigneux
Summary: Chronic kidney disease (CKD) is a global health issue with increasing prevalence. Understanding the alterations in metabolism during CKD, particularly in glucose production through gluconeogenesis, is important for developing new therapeutic targets. This review focuses on the metabolic changes in proximal tubular cells during CKD, including the switch from fatty acid oxidation to glycolysis and the loss of tubular gluconeogenesis. The consequences of these metabolic modifications on kidney disease, both locally and systemically, will be discussed. In addition, potential therapeutic interventions will be considered.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Endocrinology & Metabolism
Zijing Zhu, Jijia Hu, Zhaowei Chen, Jun Feng, Xueyan Yang, Wei Liang, Guohua Ding
Summary: Acute kidney injury (AKI) is a global public health concern, and the transition from AKI to chronic kidney disease (CKD) is complex and involves multiple mechanisms, with the metabolic reprogramming of renal tubular epithelial cells (TECs) playing a crucial role.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Fernanda Sayuri Itou Da Silva, Paulo Francisco Veiga Bizerra, Marcio Shigueaki Mito, Renato Polimeni Constantin, Eduardo Makiyama Klosowski, Byanca Thais Lima De Souza, Paulo Vinicius Moreira Da Costa Menezes, Paulo Sergio Alves Bueno, Leticia Fernanda Nanami, Rogerio Marchiosi, Wanderley Dantas Dos Santos, Osvaldo Ferrarese-Filho, Emy Luiza Ishii-Iwamoto, Rodrigo Polimeni Constantin
Summary: The acute effects of phloretin on metabolic pathways involved in glycemia maintenance were evaluated in this study. Phloretin inhibited gluconeogenesis, stimulated glycogenolysis and glycolysis, and altered oxygen consumption. It also disrupted mitochondrial bioenergetics and decreased enzyme activity. The findings suggest that caution should be exercised when using phloretin as a therapeutic agent, particularly in long-term and high-dose treatments.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Urology & Nephrology
Thomas Verissimo, Anna Faivre, Anna Rinaldi, Maja Lindenmeyer, Vasiliki Delitsikou, Christelle Veyrat-Durebex, Carolyn Heckenmeyer, Marylise Fernandez, Lena Berchtold, Delal Dalga, Clemens Cohen, Maarten Naesens, Sven-Erik Ricksten, Pierre-Yves Martin, Jerome Pugin, Franck Merlier, Karsten Haupt, Joseph M. Rutkowski, Solange Moll, Pietro E. Cippa, David Legouis, Sophie de Seigneux
Summary: Chronic kidney disease affects the renal gluconeogenic pathway, leading to systemic metabolic changes and a worse renal prognosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Zhenzhen Li, Shan Lu, Xiaobing Li
Summary: Acute kidney injury (AKI) is a common clinical syndrome that can lead to chronic kidney disease (CKD). Damage to renal tubules is a key factor in AKI progression, and metabolic reprogramming plays a crucial role in the development of AKI.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Saiqi Qi, Jie Song, Linjun Chen, Huachun Weng
Summary: This article addresses the important roles of m6A modification in kidney diseases and its molecular mechanisms. The m6A modification has been shown to regulate RNA expression through splicing, export, attenuation, and translation initiation efficiency. Understanding the impact of m6A modification in kidney diseases can provide valuable insights for diagnosis and clinical management.
MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Marya Morevati, Evandro Fei Fang, Maria L. Mace, Mehmet Kanbay, Eva Gravesen, Anders Nordholm, Soren Egstrand, Mads Hornum
Summary: This article reviews recent progress in the field of nicotinamide adenine dinucleotide (oxidized form, NAD(+)), mainly focusing on its role in acute kidney injury (AKI) and chronic kidney disease (CKD). While NAD(+) levels are reduced in AKI and conflicting results exist for CKD, increasing NAD(+) has been found beneficial for AKI. The article also discusses the compromised NAD(+) levels in renal fibrosis and senescence cells in the case of CKD. Further studies on NAD(+) in relation to AKI/CKD may provide insights for novel therapeutics, considering the urgent need for more effective treatments for patients with injured kidneys.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Stephen A. Smith, Paul E. Ronksley, Zhi Tan, Elijah Dixon, Brenda R. Hemmelgarn, W. Donald Buie, Neesh Pannu, Matthew T. James
Summary: This study found a strong association between ileostomy formation and subsequent kidney disease, leading to acute kidney injury and chronic kidney disease. Vigilance for this complication and new strategies for prevention and treatment are necessary.
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.
Article
Medicine, General & Internal
Lukasz Kuzma, Anna Tomaszuk-Kazberuk, Anna Kurasz, Malgorzata Zalewska-Adamiec, Hanna Bachorzewska-Gajewska, Slawomir Dobrzycki, Marlena Kwiatkowska, Jolanta Malyszko
Summary: Patients with atrial fibrillation (AF) scheduled for coronary angiography are at higher risk of post-contrast acute kidney injury (PC-AKI), especially those with chronic kidney disease (CKD). This study found that kidney impairment was twice as common in AF patients undergoing coronary angiography, highlighting the need for extra caution in these cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Sun Cho, Jae-Kwang Shim, Sak Lee, Jong-Wook Song, Nakcheol Choi, Sugeun Lee, Young-Lan Kwak
Summary: The study revealed that postoperative AKI in valvular heart surgery patients increases the risk of AKD and CKD development, with persistent AKI further escalating this risk. Additionally, heart failure and high right ventricular pressure postoperatively were identified as independent risk factors for CKD.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Article
Medicine, General & Internal
Chih-Hsiang Chang, Shao-Wei Chen, Jia-Jin Chen, Yi-Hsin Chan, Chieh-Li Yen, Tao Han Lee, Yu-Ting Cheng
Summary: This study found that approximately one quarter of patients undergoing surgery for acute type A aortic dissection will develop AKD. Patients with AKD, with or without AKI, are at higher risk for MAKEs and readmission. Higher-stage AKD is associated with a trend of persistent decline in kidney function.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Li-Fang Chou, Huang-Yu Yang, Cheng-Chieh Hung, Ya-Chung Tian, Shen-Hsing Hsu, Chih-Wei Yang
Summary: Leptospirosis is a neglected bacterial disease caused by leptospiral infection, which has a high mortality risk. It has been found that leptospiral infections, including acute, chronic, and asymptomatic infections, are closely linked to acute and chronic kidney disease (CKD) and renal fibrosis. Leptospires infiltrate kidney cells and survive in the kidney by evading the immune system. The binding of bacterial outer membrane protein LipL32 to toll-like receptor-2 in renal tubular epithelial cells (TECs) is the most well-known pathogenic mechanism of renal tubular damage caused by leptospiral infection.
BIOMEDICAL JOURNAL
(2023)
Article
Medicine, Research & Experimental
Chih-Hung Chiang, Ching Chen, Shih-Ying Fang, Su-Chu Lin, Jaw-Wen Chen, Ting-Ting Chang
Summary: Water hydralazine protects renal proximal tubular epithelial cells against ischemia-reperfusion injury through XO/NADPH oxidase inhibition and prevents kidney damage in AKI and AKI-to-CKD mouse models. It exerts antioxidant, anti-inflammatory, and anti-fibrotic effects both in vitro and in vivo.
Article
Physiology
Xue Hong, Yanni Zhou, Dedong Wang, Fuping Lyu, Tianjun Guan, Youhua Liu, Liangxiang Xiao
Summary: The study found that in vivo expression of exogenous Wnt1 before ischemia/reperfusion injury (IRI) protected mice against acute kidney injury (AKI) and impeded its progression to chronic kidney disease (CKD. In contrast, pretreatment with ICG-001 had no effect on renal Wnt/beta-catenin signaling or the progression of AKI to CKD. Exogenous Wnt1 suppressed proapoptotic proteins and reduced inflammatory responses in AKI and CKD mice.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Transplantation
David Legouis, Anna Faivre, Pietro E. Cippa, Sophie de Seigneux
Summary: Gluconeogenesis is a metabolic pathway that synthesizes glucose from non-hexose precursors and plays a critical role in glucose homeostasis. The kidney contributes significantly to systemic gluconeogenesis, with lactate being the main substrate. Factors such as insulin, cellular glucose levels, acidosis, and stress hormones regulate renal gluconeogenesis. Impaired renal gluconeogenesis in acute and chronic kidney disease can lead to systemic metabolic disturbances. This review highlights the importance of kidney gluconeogenesis and its implications in kidney disease.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Editorial Material
Transplantation
Anna Faivre, Sophie de Seigneux
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Lena Berchtold, Lindsey A. Crowe, Christophe Combescure, Miklos Kassai, Ibtisam Aslam, David Legouis, Solange Moll, Pierre-Yves Martin, Sophie de Seigneux, Jean-Paul Vallee
Summary: Delta ADC measured with diffusion-weighted magnetic resonance imaging can predict kidney function decline and dialysis initiation in patients with native kidney disease or kidney allograft, independent of baseline kidney function and proteinuria.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Thomas Verissimo, Anna Faivre, Sebastian Sgardello, Maarten Naesens, Sophie de Seigneux, Gilles Criton, David Legouis
Summary: Renal transplantation is the gold-standard procedure for end-stage renal disease patients, providing improved quality of life and life expectancy. By analyzing the renal metabolome after transplantation, it is possible to predict renal function one year after allograft kidney recipients, aiding in patient management optimization.
Article
Urology & Nephrology
Thomas Verissimo, Anna Faivre, Anna Rinaldi, Maja Lindenmeyer, Vasiliki Delitsikou, Christelle Veyrat-Durebex, Carolyn Heckenmeyer, Marylise Fernandez, Lena Berchtold, Delal Dalga, Clemens Cohen, Maarten Naesens, Sven-Erik Ricksten, Pierre-Yves Martin, Jerome Pugin, Franck Merlier, Karsten Haupt, Joseph M. Rutkowski, Solange Moll, Pietro E. Cippa, David Legouis, Sophie de Seigneux
Summary: Chronic kidney disease affects the renal gluconeogenic pathway, leading to systemic metabolic changes and a worse renal prognosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Anna Faivre, Romain Dissard, Willy Kuo, Thomas Verissimo, David Legouis, Gregoire Arnoux, Carolyn Heckenmeyer, Marylise Fernandez, Matthieu Tihy, Renuga D. Rajaram, Vasiliki Delitsikou, Ngoc An Le, Bernhard Spingler, Bert Mueller, Georg Shulz, Maja Lindenmeyer, Clemens Cohen, Joseph M. Rutkowski, Solange Moll, Carsten C. Scholz, Vartan Kurtcuoglu, Sophie de Seigneux
Summary: In this study, it was found that early stages of chronic kidney disease (CKD) are not characterized by hypoxia or hypoxia inducible factor (HIF) activation. Late stages of CKD showed some areas of hypoxia, but they did not colocalize with fibrosis. The HIF pathway was downregulated and FIH expression was increased in CKD. Modulating FIH activity improved glomerular filtration rate and reduced fibrosis in CKD.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Delal Dalga, Thomas Verissimo, Sophie de Seigneux
Summary: Chronic kidney disease (CKD) is a global health issue with increasing prevalence. Understanding the alterations in metabolism during CKD, particularly in glucose production through gluconeogenesis, is important for developing new therapeutic targets. This review focuses on the metabolic changes in proximal tubular cells during CKD, including the switch from fatty acid oxidation to glycolysis and the loss of tubular gluconeogenesis. The consequences of these metabolic modifications on kidney disease, both locally and systemically, will be discussed. In addition, potential therapeutic interventions will be considered.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Physiology
Thomas Verissimo, Delal Dalga, Gregoire Arnoux, Imene Sakhi, Anna Faivre, Hannah Auwerx, Soline Bourgeois, Deborah Paolucci, Quentin Gex, Joseph M. Rutkowski, David Legouis, Carsten A. Wagner, Andrew M. Hall, Sophie de Seigneux
Summary: Phosphoenolpyruvate carboxykinase 1 (PCK1) plays an important role in maintaining normal tubular physiology, lactate, and glucose homeostasis in the kidney. It regulates acid-base balance and ammoniagenesis. Downregulation of PCK1 during renal injury impairs renal function, making it a potential therapeutic target in renal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Meeting Abstract
Medicine, General & Internal
Anna Faivre, Romain Dissard, Willy Kuo, Thomas Verissimo, David Legouis, Gregoire Arnoux, Ngoc An Le, Bernhard Spingler, Bert Mueller, Georg Schulz, Maja Lindenmeyer, Clemens Cohen, Joseph M. Rutkowski, Carsten Scholz, Vartan Kurtcuoglu, Sophie De Seigneux
SWISS MEDICAL WEEKLY
(2022)
Meeting Abstract
Medicine, General & Internal
Daniele Malpetti, Anna Rinaldi, David Legouis, Gregoire Arnoux, Thomas Verissimo, Anna Faivre, Francesca Mangilil, Andrea Rinaldi, Marco Bolis, Maarten Naesens, Lorenzo Ruinelli, Jerome Pugin, Solange Moll', Laura Azzimontil, Sophie De Seigneux, Pietro Cippa
SWISS MEDICAL WEEKLY
(2022)
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)