Metabolic reprogramming and tolerance during sepsis-induced AKI

The Effects of Alternative Resuscitation Strategies on Acute Kidney Injury in Patients with Septic Shock

(2016) John A. Kellum et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Sepsis results in an altered renal metabolic and osmolyte profile

(2016) Paul Waltz et al.   JOURNAL OF SURGICAL RESEARCH

PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection

(2016) Mei T. Tran et al.   NATURE

Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis

(2016) Shih-Chin Cheng et al.   NATURE IMMUNOLOGY

AMPKα2 reduces renal epithelial transdifferentiation and inflammation after injury through interaction with CK2β

(2015) Shulan Qiu et al.   JOURNAL OF PATHOLOGY

Adenosine monophosphate-activated protein kinase activation protects against sepsis-induced organ injury and inflammation

(2015) Daniel A. Escobar et al.   JOURNAL OF SURGICAL RESEARCH

Deletion of Lkb1 in Renal Tubular Epithelial Cells Leads to CKD by Altering Metabolism

(2015) S. H. Han et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Progression after AKI: Understanding Maladaptive Repair Processes to Predict and Identify Therapeutic Treatments

(2015) D. P. Basile et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Sepsis: a roadmap for future research

(2015) Jonathan Cohen et al.   LANCET INFECTIOUS DISEASES

Control of adaptive immunity by the innate immune system

(2015) Akiko Iwasaki et al.   NATURE IMMUNOLOGY

Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

(2014) Azra Bihorac et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

(2014) Vidula T. Vachharajani et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

(2014) Hyun Mi Kang et al.   NATURE MEDICINE

Plasma inflammatory and apoptosis markers are associated with dialysis dependence and death among critically ill patients receiving renal replacement therapy

(2014) Raghavan Murugan et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Renal Functional Reserve and Renal Recovery after Acute Kidney Injury

(2014) Aashish Sharma et al.   NEPHRON CLINICAL PRACTICE

mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

(2014) K M Dodd et al.   ONCOGENE

Staphylococcus aureus Sepsis Induces Early Renal Mitochondrial DNA Repair and Mitochondrial Biogenesis in Mice

(2014) Raquel R. Bartz et al.   PLoS One

mTOR- and HIF-1 -mediated aerobic glycolysis as metabolic basis for trained immunity

(2014) S.-C. Cheng et al.   SCIENCE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis

(2013) Osamu Takasu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Experimental sepsis-induced mitochondrial biogenesis is dependent on autophagy, TLR4, and TLR9 signaling in liver

(2013) Evie H. Carchman et al.   FASEB JOURNAL

Anthracyclines Induce DNA Damage Response-Mediated Protection against Severe Sepsis

(2013) Nuno Figueiredo et al.   IMMUNITY

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

'Biologic memory' in response to acute kidney injury: cytoresistance, toll-like receptor hyper-responsiveness * and the onset of progressive renal disease

(2013) R. A. Zager   NEPHROLOGY DIALYSIS TRANSPLANTATION

Augmenting Autophagy to Treat Acute Kidney Injury during Endotoxemia in Mice

(2013) Gina M. Howell et al.   PLoS One

A Unified Theory of Sepsis-Induced Acute Kidney Injury

(2013) Hernando Gomez et al.   SHOCK

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Predicting progression to chronic kidney disease after recovery from acute kidney injury

(2012) Michael Heung et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

NAD+-dependent Sirtuin 1 and 6 Proteins Coordinate a Switch from Glucose to Fatty Acid Oxidation during the Acute Inflammatory Response

(2012) Tie Fu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted proximal tubule injury triggers interstitial fibrosis and glomerulosclerosis

(2012) Ivica Grgic et al.   KIDNEY INTERNATIONAL

When more is less

(2012) Lei Jiang et al.   NATURE

AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress

(2012) Sang-Min Jeon et al.   NATURE

Disease Tolerance as a Defense Strategy

(2012) R. Medzhitov et al.   SCIENCE

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

Heme oxygenase-1-mediated autophagy protects against hepatocyte cell death and hepatic injury from infection/sepsis in mice

(2011) Evie H. Carchman et al.   HEPATOLOGY

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Endotoxin Uptake by S1 Proximal Tubular Segment Causes Oxidative Stress in the Downstream S2 Segment

(2011) R. Kalakeche et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute kidney injury: what's the prognosis?

(2011) Raghavan Murugan et al.   Nature Reviews Nephrology

Tubulointerstitial injury and the progression of chronic kidney disease

(2011) Kavita S. Hodgkins et al.   PEDIATRIC NEPHROLOGY

The Decline of Autophagy Contributes to Proximal Tubular Dysfunction During Sepsis

(2011) Hsiu-Wen Hsiao et al.   SHOCK

Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network

(2010) Richard C. Scarpulla   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

A Central Role for Free Heme in the Pathogenesis of Severe Sepsis

(2010) R. Larsen et al.   Science Translational Medicine

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Mitochondria and calcium in health and disease

(2008) M DUCHEN et al.   CELL CALCIUM

Renal repair and recovery

(2008) Kathleen D. Liu et al.   CRITICAL CARE MEDICINE

Pathways of renal injury in systemic gram-negative sepsis

(2008) T. M. El-Achkar et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

A central role for free heme in the pathogenesis of severe malaria: the missing link?

(2008) Ana Ferreira et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Endotoxin Mediates Recruitment of RNA Polymerase II to Target Genes in Acute Renal Failure

(2008) M. Naito et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY