AMPK regulation of Raptor and TSC2 mediate metformin effects on transcriptional control of anabolism and inflammation

AMPK and TOR: The Yin and Yang of Cellular Nutrient Sensing and Growth Control

(2020) Asier González et al.   Cell Metabolism

Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer

(2020) Benjamin D. Hopkins et al.   Nature Reviews Endocrinology

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Global analysis of LARP1 translation targets reveals tunable and dynamic features of 5′ TOP motifs

(2020) Lucas Philippe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Liver-Specific AMPK Activation Protects against Diet-Induced Obesity and NAFLD

(2019) Daniel Garcia et al.   Cell Reports

Role of Mitochondria in the Mechanism(s) of Action of Metformin

(2019) Guillaume Vial et al.   Frontiers in Endocrinology

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

Metformin improves obesity-associated inflammation by altering macrophages polarization

(2018) Yuanyuan Jing et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mTOR Senses Environmental Cues to Shape the Fibroblast-like Synoviocyte Response to Inflammation

(2018) Thomas Karonitsch et al.   Cell Reports

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

(2018) Lillian J. Eichner et al.   Cell Metabolism

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy

(2017) Robert W. Myers et al.   SCIENCE

Are Metformin Doses Used in Murine Cancer Models Clinically Relevant?

(2016) Navdeep S. Chandel et al.   Cell Metabolism

Anti-Inflammatory Effects of Metformin Irrespective of Diabetes StatusNovelty and Significance

(2016) Amy R. Cameron et al.   CIRCULATION RESEARCH

AMPK governs lineage specification through Tfeb-dependent regulation of lysosomes

(2016) Nathan P. Young et al.   GENES & DEVELOPMENT

Current understanding of metformin effect on the control of hyperglycemia in diabetes

(2016) Hongying An et al.   JOURNAL OF ENDOCRINOLOGY

Metformin Action: Concentrations Matter

(2015) Ling He et al.   Cell Metabolism

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways

(2015) Ana P Gomes et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

(2015) Yoshifumi Saisho   Endocrine Metabolic & Immune Disorders-Drug Targets

5-Aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) Effect on Glucose Production, but Not Energy Metabolism, Is Independent of Hepatic AMPKin Vivo

(2014) Clinton M. Hasenour et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generating genetically modified mice using CRISPR/Cas-mediated genome engineering

(2014) Hui Yang et al.   Nature Protocols

Suppression of the mTORC1/STAT3/Notch1 pathway by activated AMPK prevents hepatic insulin resistance induced by excess amino acids

(2013) Hongliang Li et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Efficacy of the investigational mTOR kinase inhibitor MLN0128/INK128 in models of B-cell acute lymphoblastic leukemia

(2012) M R Janes et al.   LEUKEMIA

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

(2010) Junyu Ning et al.   MOLECULAR ENDOCRINOLOGY

mTORC1 controls fasting-induced ketogenesis and its modulation by ageing

(2010) Shomit Sengupta et al.   NATURE

Inactivation of Mammalian Target of Rapamycin Increases STAT1 Nuclear Content and Transcriptional Activity in α4- and Protein Phosphatase 2A-dependent Fashion

(2009) Jill A. Fielhaber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signal Transducer and Activator of Transcription 3 (STAT3) Mediates Amino Acid Inhibition of Insulin Signaling through Serine 727 Phosphorylation

(2009) Jeong-Ho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SUnSET, a nonradioactive method to monitor protein synthesis

(2009) Enrico K Schmidt et al.   NATURE METHODS

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL