LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
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Title
LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs
Authors
Keywords
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Journal
eLife
Volume 6, Issue -, Pages -
Publisher
eLife Sciences Organisation, Ltd.
Online
2017-06-26
DOI
10.7554/elife.25237
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Note: Only part of the references are listed.- Translational control by 5'-untranslated regions of eukaryotic mRNAs
- (2016) A. G. Hinnebusch et al. SCIENCE
- The race to decipher the top secrets of TOP mRNAs
- (2015) Oded Meyuhas et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
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- (2015) Bruno D. Fonseca et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Targeting the translation machinery in cancer
- (2015) Mamatha Bhat et al. NATURE REVIEWS DRUG DISCOVERY
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- (2015) Thomas G. Hopkins et al. NUCLEIC ACIDS RESEARCH
- The La-related protein 1-specific domain repurposes HEAT-like repeats to directly bind a 5′TOP sequence
- (2015) Roni M. Lahr et al. NUCLEIC ACIDS RESEARCH
- An AXIN2 Mutant Allele Associated With Predisposition to Colorectal Neoplasia Has Context-Dependent Effects on AXIN2 Protein Function
- (2015) Serina M. Mazzoni et al. NEOPLASIA
- Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation
- (2014) J. Tcherkezian et al. GENES & DEVELOPMENT
- Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner
- (2014) Rachel Miloslavski et al. Journal of Molecular Cell Biology
- LARP1 specifically recognizes the 3′ terminus of poly(A) mRNA
- (2013) Kazuma Aoki et al. FEBS LETTERS
- A compendium of RNA-binding motifs for decoding gene regulation
- (2013) Debashish Ray et al. NATURE
- Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
- (2013) Christian C. Dibble et al. NATURE CELL BIOLOGY
- mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin
- (2013) S. A. Kang et al. SCIENCE
- Pervasive and dynamic protein binding sites of the mRNA transcriptome in Saccharomyces cerevisiae
- (2013) Mallory A Freeberg et al. GENOME BIOLOGY
- A unifying model for mTORC1-mediated regulation of mRNA translation
- (2012) Carson C. Thoreen et al. NATURE
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms
- (2011) Fran Supek et al. PLoS One
- Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
- (2011) Y. Yu et al. SCIENCE
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Therapeutic Targeting of SPINK1-Positive Prostate Cancer
- (2011) B. Ateeq et al. Science Translational Medicine
- Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)
- (2010) Mark A. Bayfield et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP
- (2010) Markus Hafner et al. CELL
- The RNA binding protein Larp1 regulates cell division, apoptosis and cell migration
- (2010) C. Burrows et al. NUCLEIC ACIDS RESEARCH
- TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
- (2009) J. Copp et al. CANCER RESEARCH
- Drosophila Larp associates with poly(A)-binding protein and is required for male fertility and syncytial embryo development
- (2009) Sarah P. Blagden et al. DEVELOPMENTAL BIOLOGY
- MEME SUITE: tools for motif discovery and searching
- (2009) T. L. Bailey et al. NUCLEIC ACIDS RESEARCH
- A comprehensive analysis of the La-motif protein superfamily
- (2009) C. Bousquet-Antonelli et al. RNA
- Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
- (2009) Ben Langmead et al. GENOME BIOLOGY
- SM-164: A Novel, Bivalent Smac Mimetic That Induces Apoptosis and Tumor Regression by Concurrent Removal of the Blockade of cIAP-1/2 and XIAP
- (2008) J. Lu et al. CANCER RESEARCH
- Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 Gene Fusions in Prostate Cancer
- (2008) B. E. Helgeson et al. CANCER RESEARCH
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