mTORC1 and CK2 coordinate ternary and eIF4F complex assembly

eIF2α phosphorylation bypasses premature senescence caused by oxidative stress and pro-oxidant antitumor therapies

(2016) Kamindla Rajesh et al.   Aging-US

Roles of the translation initiation factor eIF2α serine 51 phosphorylation in cancer formation and treatment

(2015) Antonis E. Koromilas   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

mTOR signaling in cellular and organismal energetics

(2015) Verena Albert et al.   CURRENT OPINION IN CELL BIOLOGY

Coordinated Regulation of the Neutral Amino Acid Transporter SNAT2 and the Protein Phosphatase Subunit GADD34 Promotes Adaptation to Increased Extracellular Osmolarity

(2015) Dawid Krokowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC2 Balances AKT Activation and eIF2  Serine 51 Phosphorylation to Promote Survival under Stress

(2015) C. Tenkerian et al.   MOLECULAR CANCER RESEARCH

Conformational Differences between Open and Closed States of the Eukaryotic Translation Initiation Complex

(2015) Jose L. Llácer et al.   MOLECULAR CELL

Targeting the translation machinery in cancer

(2015) Mamatha Bhat et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphorylation of eIF2  triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma

(2015) J. Wengrod et al.   Science Signaling

Phosphorylation of the translation initiation factor eIF2α at serine 51 determines the cell fate decisions of Akt in response to oxidative stress

(2015) K Rajesh et al.   Cell Death & Disease

Phosphorylation of eIF2  triggered by mTORC1 inhibition and PP6C activation is required for autophagy and is aberrant in PP6C-mutated melanoma

(2015) J. Wengrod et al.   Science Signaling

The Scanning Mechanism of Eukaryotic Translation Initiation

(2014) Alan G. Hinnebusch   Annual Review of Biochemistry

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

(2014) J. Tcherkezian et al.   GENES & DEVELOPMENT

Translational Control during Endoplasmic Reticulum Stress beyond Phosphorylation of the Translation Initiation Factor eIF2α

(2014) Bo-Jhih Guan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

(2014) Thomas D. Baird et al.   MOLECULAR BIOLOGY OF THE CELL

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

(2014) Rachel Miloslavski et al.   Journal of Molecular Cell Biology

Internal ribosome entry site-mediated translational regulation of ATF4 splice variant in mammalian unfolded protein response

(2013) Ching-Ping Chan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling

(2013) F Buontempo et al.   LEUKEMIA

Interaction of Nck1 and PERK phosphorylated at Y561 negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content

(2013) Lama Yamani et al.   MOLECULAR BIOLOGY OF THE CELL

Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis

(2013) A. M. Robitaille et al.   SCIENCE

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

(2013) S. A. Kang et al.   SCIENCE

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Fission yeast TORC1 prevents eIF2  phosphorylation in response to nitrogen and amino acids via Gcn2 kinase

(2012) N. Valbuena et al.   JOURNAL OF CELL SCIENCE

A unifying model for mTORC1-mediated regulation of mRNA translation

(2012) Carson C. Thoreen et al.   NATURE

The translational landscape of mTOR signalling steers cancer initiation and metastasis

(2012) Andrew C. Hsieh et al.   NATURE

Translation termination efficiency modulates ATF4 response by regulating ATF4 mRNA translation at 5′ short ORFs

(2012) Hayet Ait Ghezala et al.   NUCLEIC ACIDS RESEARCH

Distinct perturbation of the translatome by the antidiabetic drug metformin

(2012) O. Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The C-Terminal Domain of Eukaryotic Initiation Factor 5 Promotes Start Codon Recognition by Its Dynamic Interplay with eIF1 and eIF2β

(2012) Rafael E. Luna et al.   Cell Reports

Unbiased Functional Proteomics Strategy for Protein Kinase Inhibitor Validation and Identification ofbona fideProtein Kinase Substrates: Application to Identification of EEF1D as a Substrate for CK2

(2011) Laszlo Gyenis et al.   JOURNAL OF PROTEOME RESEARCH

Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling

(2011) Y. Yu et al.   SCIENCE

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2  Phosphorylation Pathway

(2011) Z. Mounir et al.   Science Signaling

System-Wide Temporal Characterization of the Proteome and Phosphoproteome of Human Embryonic Stem Cell Differentiation

(2011) K. T. G. Rigbolt et al.   Science Signaling

The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

(2010) Y J Kang et al.   CELL DEATH AND DIFFERENTIATION

Both Transcriptional Regulation and Translational Control of ATF4 Are Central to the Integrated Stress Response

(2010) Souvik Dey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Deletion of eIF2beta suppresses testicular cancer incidence and causes recessive lethality in agouti-yellow mice

(2009) Jason D. Heaney et al.   HUMAN MOLECULAR GENETICS

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2  Phosphorylation Pathway

(2009) Z. Mounir et al.   Science Signaling

Intersubunit and interprotein interactions of α- and β-subunits of human eIF2: Effect of phosphorylation

(2008) Kamindla Rajesh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the Eukaryotic Translation Initiation Factor 4E for Cancer Therapy

(2008) J. R. Graff et al.   CANCER RESEARCH