mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

KinCon: Cell‐based recording of full‐length kinase conformations

(2020) Florian Enzler et al.   IUBMB LIFE

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation

(2020) Po-Chien Chou et al.   Cells

PHLPPing the Script: Emerging Roles of PHLPP Phosphatases in Cell Signaling

(2020) Timothy R. Baffi et al.   Annual Review of Pharmacology and Toxicology

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer

(2019) Timothy R. Baffi et al.   MOLECULAR CELL

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS

(2019) Ruth Röck et al.   Science Advances

AKTivation mechanisms

(2019) Philip A Cole et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity

(2018) Nileeka Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AGC kinases, mechanisms of regulation ‎and innovative drug development

(2018) Alejandro E. Leroux et al.   SEMINARS IN CANCER BIOLOGY

Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources

(2018) Liang-Chin Huang et al.   Scientific Reports

Single-color, ratiometric biosensors for detecting signaling activities in live cells

(2018) Brian L Ross et al.   eLife

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

(2018) Nam Chu et al.   CELL

Coral: Clear and Customizable Visualization of Human Kinome Data

(2018) Kathleen S. Metz et al.   Cell Systems

Quantitative Temporal Viromics of an Inducible HIV-1 Model Yields Insight to Global Host Targets and Phospho-Dynamics Associated with Protein Vpr

(2017) John D. Lapek et al.   MOLECULAR & CELLULAR PROTEOMICS

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

The ClusPro web server for protein–protein docking

(2017) Dima Kozakov et al.   Nature Protocols

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression

(2017) Chun-Song Yang et al.   PROSTATE

Reversing the Paradigm: Protein Kinase C as a Tumor Suppressor

(2017) Alexandra C. Newton et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

PKCα diffusion and translocation are independent of an intact cytoskeleton

(2017) Xin Hui et al.   Scientific Reports

Substrate specificity of TOR complex 2 is determined by a ubiquitin-fold domain of the Sin1 subunit

(2017) Hisashi Tatebe et al.   eLife

Discovery and optimization of 1,7-disubstituted-2,2-dimethyl-2,3-dihydroquinazolin-4(1 H )-ones as potent and selective PKC θ inhibitors

(2016) Taisuke Katoh et al.   BIOORGANIC & MEDICINAL CHEMISTRY

KinView: a visual comparative sequence analysis tool for integrated kinome research

(2016) Daniel Ian McSkimming et al.   Molecular BioSystems

Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor

(2016) Vanessa S. Rodrik-Outmezguine et al.   NATURE

How Do Protein Kinases Take a Selfie (Autophosphorylate)?

(2016) Jonah Beenstock et al.   TRENDS IN BIOCHEMICAL SCIENCES

Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor

(2015) Corina E. Antal et al.   CELL

A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances

(2015) Marco Y. Hein et al.   CELL

In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs

(2015) Ruth Röck et al.   Scientific Reports

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

(2015) Corina E. Antal et al.   Cell Reports

Single-Molecule Studies Reveal a Hidden Key Step in the Activation Mechanism of Membrane-Bound Protein Kinase C-α

(2014) Brian P. Ziemba et al.   BIOCHEMISTRY

Intramolecular Conformational Changes Optimize Protein Kinase C Signaling

(2014) Corina E. Antal et al.   CHEMISTRY & BIOLOGY

Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα

(2014) Carter J. Swanson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Targeting Activated Akt with GDC-0068, a Novel Selective Akt Inhibitor That Is Efficacious in Multiple Tumor Models

(2013) J. Lin et al.   CLINICAL CANCER RESEARCH

Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

(2012) M. M. Keshwani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

(2012) K. Lin et al.   Science Signaling

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

mTORC2 targets AGC kinases through Sin1-dependent recruitment

(2011) Angus J. M. Cameron et al.   BIOCHEMICAL JOURNAL

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes

(2011) Maurice J. van Eis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal Structure and Allosteric Activation of Protein Kinase C βII

(2011) Thomas A. Leonard et al.   CELL

Mammalian TOR signaling to the AGC kinases

(2011) Bing Su et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Disruption of the Interface between the Pleckstrin Homology (PH) and Kinase Domains of Akt Protein Is Sufficient for Hydrophobic Motif Site Phosphorylation in the Absence of mTORC2

(2011) Noel A. Warfel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active Site Inhibitors Protect Protein Kinase C from Dephosphorylation and Stabilize Its Mature Form

(2011) Christine M. Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

Rapid detection, classification and accurate alignment of up to a million or more related protein sequences

(2009) Andrew F. Neuwald   BIOINFORMATICS

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity

(2009) Angus J M Cameron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A chimeric mechanism for polyvalenttrans-phosphorylation of PKA by PDK1

(2009) Robert A. Romano et al.   PROTEIN SCIENCE

New Insights into mTOR Signaling: mTORC2 and Beyond

(2009) D. R. Alessi et al.   Science Signaling

mTORC2 is the hydrophobic motif kinase for SGK1

(2008) Lijun Yan et al.   BIOCHEMICAL JOURNAL

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail

(2008) Christine M. Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3K pathway alterations in cancer: variations on a theme

(2008) T L Yuan et al.   ONCOGENE