Regulation of Autophagy Enzymes by Nutrient Signaling

Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer

(2019) Sandhya Chipurupalli et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant

(2019) Reham M Alsaadi et al.   EMBO REPORTS

Iron overload inhibits late stage autophagic flux leading to insulin resistance

(2019) James Won Suk Jahng et al.   EMBO REPORTS

An antibody for analysis of autophagy induction

(2019) Wensheng Tian et al.   NATURE METHODS

ULK1 phosphorylates Ser30 of BECN1 in association with ATG14 to stimulate autophagy induction

(2018) Ji-Man Park et al.   Autophagy

The RAB11A-Positive Compartment Is a Primary Platform for Autophagosome Assembly Mediated by WIPI2 Recognition of PI3P-RAB11A

(2018) Claudia Puri et al.   DEVELOPMENTAL CELL

A molecular perspective of mammalian autophagosome biogenesis

(2018) Thomas J. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of ULK1 affects autophagosome fusion and links chaperone-mediated autophagy to macroautophagy

(2018) Chenyao Wang et al.   Nature Communications

mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux

(2018) Wei Wan et al.   MOLECULAR CELL

The mammalian ULK1 complex and autophagy initiation

(2017) Maria Zachari et al.   Essays in Biochemistry

Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK

(2017) Chen-Song Zhang et al.   NATURE

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

(2017) Toby A. Dite et al.   Nature Communications

Phosphoinositides in Control of Membrane Dynamics

(2016) Kay O. Schink et al.   Annual Review of Cell and Developmental Biology

The ULK1 complex mediates MTORC1 signaling to the autophagy initiation machinery via binding and phosphorylating ATG14

(2016) Ji-Man Park et al.   Autophagy

AMPK regulates autophagy by phosphorylating BECN1 at threonine 388

(2016) Deyi Zhang et al.   Autophagy

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

(2016) Changqian Zhou et al.   CELL RESEARCH

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

(2016) D.-Q. Xu et al.   EMBO JOURNAL

Nutrient-regulated Phosphorylation of ATG13 Inhibits Starvation-induced Autophagy

(2016) Cindy Puente et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation

(2016) Francesca Nazio et al.   JOURNAL OF CELL BIOLOGY

Atg9A trafficking through the recycling endosomes is required for autophagosome formation

(2016) Kenta Imai et al.   JOURNAL OF CELL SCIENCE

Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination

(2016) Chin-Chih Liu et al.   MOLECULAR CELL

Hypoxia induces autophagy in cardiomyocytes via a hypoxia-inducible factor 1-dependent mechanism

(2016) LAN GUI et al.   Experimental and Therapeutic Medicine

Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

(2016) Mee-Sup Yoon et al.   Cell Reports

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Role of Autophagy as a Survival Mechanism for Hypoxic Cells in Tumors

(2016) Qian Tan et al.   NEOPLASIA

ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation

(2015) Huiwen Song et al.   Autophagy

mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival

(2015) M. J. Munson et al.   EMBO JOURNAL

Membrane dynamics in autophagosome biogenesis

(2015) S. R. Carlsson et al.   JOURNAL OF CELL SCIENCE

mTORC1 Phosphorylates UVRAG to Negatively Regulate Autophagosome and Endosome Maturation

(2015) Young-Mi Kim et al.   MOLECULAR CELL

PI(5)P Regulates Autophagosome Biogenesis

(2015) Mariella Vicinanza et al.   MOLECULAR CELL

Small Molecule Inhibition of the Autophagy Kinase ULK1 and Identification of ULK1 Substrates

(2015) Daniel F. Egan et al.   MOLECULAR CELL

Autophagy at the crossroads of catabolism and anabolism

(2015) Jasvinder Kaur et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

(2015) S. Wang et al.   SCIENCE

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A

(2015) Pui-Mun Wong et al.   Nature Communications

RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK

(2015) Yawei Zhao et al.   Cell Reports

The stress-responsive kinases MAPKAPK2/MAPKAPK3 activate starvation-induced autophagy through Beclin 1 phosphorylation

(2015) Yongjie Wei et al.   eLife

Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia–ischemia: Role of protein synthesis and autophagic pathways

(2014) Silvia Carloni et al.   EXPERIMENTAL NEUROLOGY

Metabolic-Stress-Induced Rearrangement of the 14-3-3  Interactome Promotes Autophagy via a ULK1- and AMPK-Regulated 14-3-3  Interaction with Phosphorylated Atg9

(2014) V. K. Weerasekara et al.   MOLECULAR AND CELLULAR BIOLOGY

WIPI2 Links LC3 Conjugation with PI3P, Autophagosome Formation, and Pathogen Clearance by Recruiting Atg12–5-16L1

(2014) Hannah C. Dooley et al.   MOLECULAR CELL

Cargo recognition and trafficking in selective autophagy

(2014) Alexandra Stolz et al.   NATURE CELL BIOLOGY

Autophagy—a key player in cellular and body metabolism

(2014) Kook Hwan Kim et al.   Nature Reviews Endocrinology

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Temporal analysis of recruitment of mammalian ATG proteins to the autophagosome formation site

(2013) Ikuko Koyama-Honda et al.   Autophagy

Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2

(2013) Fiona McAlpine et al.   Autophagy

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

(2013) Hai-Xin Yuan et al.   Autophagy

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

(2013) Joungmok Kim et al.   CELL

AMP Is a True Physiological Regulator of AMP-Activated Protein Kinase by Both Allosteric Activation and Enhancing Net Phosphorylation

(2013) Graeme J. Gowans et al.   Cell Metabolism

FIP200 regulates targeting of Atg16L1 to the isolation membrane

(2013) Taki Nishimura et al.   EMBO REPORTS

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

Regulation of Mammalian Autophagy by Class II and III PI 3-Kinases through PI3P Synthesis

(2013) Kelly Devereaux et al.   PLoS One

Identification of ROCK1 kinase as a critical regulator of Beclin1-mediated autophagy during metabolic stress

(2013) Aditi U. Gurkar et al.   Nature Communications

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

Autophagy

(2012) Ricky H. Bhogal et al.   Autophagy

MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB

(2012) Jose A. Martina et al.   Autophagy

Atg9 vesicles are an important membrane source during early steps of autophagosome formation

(2012) Hayashi Yamamoto et al.   JOURNAL OF CELL BIOLOGY

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Interaction between FIP200 and ATG16L1 distinguishes ULK1 complex–dependent and –independent autophagy

(2012) Noor Gammoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

(2012) S.-Y. Lin et al.   SCIENCE

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

ULK1 inhibits the kinase activity of mTORC1 and cell proliferation

(2011) Chang Hwa Jung et al.   Autophagy

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

(2011) Junji Ezaki et al.   Autophagy

ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding

(2011) Elaine A. Dunlop et al.   Autophagy

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop

(2011) Antje S. Löffler et al.   Autophagy

Structure of mammalian AMPK and its regulation by ADP

(2011) Bing Xiao et al.   NATURE

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

(2011) L. Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ammonia-induced autophagy is independent of ULK1/ULK2 kinases

(2011) H. Cheong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

(2011) J. S. Oakhill et al.   SCIENCE

Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

(2010) Eisuke Itakura et al.   Autophagy

Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning

(2010) Rui Sheng et al.   Autophagy

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

(2010) Dale W. Hailey et al.   CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy

(2010) Sabrina Di Bartolomeo et al.   JOURNAL OF CELL BIOLOGY

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

(2010) D. F. Egan et al.   SCIENCE

Hypoxia-Induced Autophagy Is Mediated through Hypoxia-Inducible Factor Induction of BNIP3 and BNIP3L via Their BH3 Domains

(2009) G. Bellot et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

(2008) Huafeng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Atg4B Mutant Hampers the Lipidation of LC3 Paralogues and Causes Defects in Autophagosome Closure

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy

(2008) Naonobu Fujita et al.   MOLECULAR BIOLOGY OF THE CELL

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

(2008) Yongjie Wei et al.   MOLECULAR CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Protective role of autophagy in neonatal hypoxia–ischemia induced brain injury

(2008) Silvia Carloni et al.   NEUROBIOLOGY OF DISEASE

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE