PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

(2011) Laura R. Pearce et al.   BIOCHEMICAL JOURNAL

Activation of mTORC2 by Association with the Ribosome

(2011) Vittoria Zinzalla et al.   CELL

Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate

(2011) Xiaoqing Gan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LPA Receptors: Subtypes and Biological Actions

(2010) Ji Woong Choi et al.   Annual Review of Pharmacology and Toxicology

Protein Kinase Cδ Deficiency Accelerates Neointimal Lesions of Mouse Injured Artery Involving Delayed Reendothelialization and Vasohibin-1 Accumulation

(2010) Xue Bai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Gα12 is critical for TCR-induced IL-2 production and differentiation of T helper 2 and T helper 17 cells

(2010) Hee Yeon Won et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

mTORC2 Regulates Neutrophil Chemotaxis in a cAMP- and RhoA-Dependent Fashion

(2010) Lunhua Liu et al.   DEVELOPMENTAL CELL

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

Different Roles of G Protein Subunits β1and β2in Neutrophil Function Revealed by Gene Expression Silencing in Primary Mouse Neutrophils

(2010) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

(2009) J. Copp et al.   CANCER RESEARCH

mTOR and the control of whole body metabolism

(2009) Pazit Polak et al.   CURRENT OPINION IN CELL BIOLOGY

Guanine Nucleotide-Binding Proteins of the G12 Family Shape Immune Functions by Controlling CD4+ T Cell Adhesiveness and Motility

(2009) Susanne Herroeder et al.   IMMUNITY

mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

(2009) Ghada A. Soliman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic acid-induced ERK activation and chemotaxis in MC3T3-E1 preosteoblasts are independent of EGF receptor transactivation

(2009) Sue A. Karagiosis et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PKCδ regulates cortical radial migration by stabilizing the Cdk5 activator p35

(2009) Chun-tao Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TOR regulation of AGC kinases in yeast and mammals

(2008) Estela Jacinto et al.   BIOCHEMICAL JOURNAL

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

CARP-2 Is an Endosome-Associated Ubiquitin Ligase for RIP and Regulates TNF-Induced NF-κB Activation

(2008) Wentao Liao et al.   CURRENT BIOLOGY

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

The proteasome inhibitor bortezomib depletes plasma cells and protects mice with lupus-like disease from nephritis

(2008) Kirsten Neubert et al.   NATURE MEDICINE

G12/G13-mediated signalling in mammalian physiology and disease

(2008) Thomas Worzfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES