The adhesion GPCR Adgrg6 (Gpr126): Insights from the zebrafish model

Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain

(2021) Gerti Beliu et al.   MOLECULAR CELL

Structures of the glucocorticoid-bound adhesion receptor GPR97–Go complex

(2021) Yu-Qi Ping et al.   NATURE

Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish

(2021) Marion Rosello et al.   eLife

Structural basis for adhesion G protein-coupled receptor Gpr126 function

(2020) Katherine Leon et al.   Nature Communications

Building bridges, not walls: spinal cord regeneration in zebrafish

(2020) Valentina Cigliola et al.   Disease Models & Mechanisms

Dynamic properties of noise and Her6 levels are optimized by miR‐9, allowing the decoding of the Her6 oscillator

(2020) Ximena Soto et al.   EMBO JOURNAL

Efficient targeted integration directed by short homology in zebrafish and mammalian cells

(2020) Wesley A Wierson et al.   eLife

Regulation of body length and bone mass by Gpr126/Adgrg6

(2020) Peng Sun et al.   Science Advances

The structural biology of canonical Wnt signalling

(2020) Mark Agostino et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Opportunities and challenges for drug discovery in modulating Adhesion G protein-coupled receptor (GPCR) functions

(2020) Andrey D. Bondarev et al.   Expert Opinion on Drug Discovery

Mechanisms of Adhesion G protein Coupled Receptor Activation

(2020) Alexander Vizurraga et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent insights into zebrafish cardiac regeneration

(2020) Andrés Sanz-Morejón et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

An adhesion code ensures robust pattern formation during tissue morphogenesis

(2020) Tony Y.-C. Tsai et al.   SCIENCE

A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126)

(2020) Enric Lizano et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

An optimized base editor with efficient C-to-T base editing in zebrafish

(2020) Yu Zhao et al.   BMC BIOLOGY

Tension heterogeneity directs form and fate to pattern the myocardial wall

(2020) Rashmi Priya et al.   NATURE

Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration

(2019) Melissa Ducommun Priest et al.   PLoS Genetics

Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer

(2019) Song Wu et al.   Nature Communications

Adhesion G protein-coupled receptors - candidate metabotropic mechanosensors and novel drug targets

(2019) Tobias Langenhan   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

COL4A1 Mutations Cause Neuromuscular Disease with Tissue-Specific Mechanistic Heterogeneity

(2019) Cassandre Labelle-Dumais et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population

(2019) Enjie Xu et al.   EUROPEAN SPINE JOURNAL

Genetic compensation triggered by mutant mRNA degradation

(2019) Mohamed A. El-Brolosy et al.   NATURE

The expanding functional roles and signaling mechanisms of adhesion G protein–coupled receptors

(2019) Rory K. Morgan et al.   Annals of the New York Academy of Sciences

Revisiting the classification of adhesion GPCRs

(2019) Nicole Scholz et al.   Annals of the New York Academy of Sciences

Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli

(2019) Gentian Musa et al.   Annals of the New York Academy of Sciences

Developing zebrafish disease models for in vivo small molecule screens

(2019) Pui-Ying Lam et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Identification of compounds that rescue otic and myelination defects in the zebrafish adgrg6 (gpr126) mutant

(2019) Elvira Diamantopoulou et al.   eLife

In vivo identification of small molecules mediating Gpr126/Adgrg6 signaling during Schwann cell development

(2019) Ethan C. Bradley et al.   Annals of the New York Academy of Sciences

miR‐27a/b is a posttranscriptional regulator of Gpr126 ( Adgrg6 )

(2019) Gentian Musa et al.   Annals of the New York Academy of Sciences

Shaping the zebrafish myotome by intertissue friction and active stress

(2019) S. Tlili et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice

(2019) Zhaoyang Liu et al.   PLoS Genetics

Gpr126/Adgrg6 contributes to the terminal Schwann cell response at the neuromuscular junction following peripheral nerve injury

(2019) Albina Jablonka‐Shariff et al.   GLIA

Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish

(2019) Gopi Shah et al.   Nature Communications

Linking wound response and inflammation to regeneration in the zebrafish larval fin

(2018) Henry Hamilton Roehl   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

Optimized knock-in of point mutations in zebrafish using CRISPR/Cas9

(2018) Sergey V Prykhozhij et al.   NUCLEIC ACIDS RESEARCH

An automated high-resolution in vivo screen in zebrafish to identify chemical regulators of myelination

(2018) Jason J Early et al.   eLife

Heritability and genome-wide association study of diffusing capacity of the lung

(2018) Natalie Terzikhan et al.   EUROPEAN RESPIRATORY JOURNAL

A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis

(2018) Ikuyo Kou et al.   Scientific Reports

GPR126 : A novel candidate gene implicated in autosomal recessive intellectual disability

(2018) Masoumeh Hosseini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

From Drosophila segmentation to human cancer therapy

(2018) Philip W. Ingham   DEVELOPMENT

High Prevalence of a Hotspot of Noncoding Somatic Mutations in Intron 6 of GPR126 in Bladder Cancer

(2018) Simon Garinet et al.   MOLECULAR CANCER RESEARCH

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population

(2017) Xiaodong Qin et al.   SPINE

Mini-G proteins: Novel tools for studying GPCRs in their active conformation

(2017) Rony Nehmé et al.   PLoS One

Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations

(2017) Christina A. Eichstaedt et al.   Scientific Reports

Gpr126/Adgrg6 Has Schwann Cell Autonomous and Nonautonomous Functions in Peripheral Nerve Injury and Repair

(2016) Amit Mogha et al.   JOURNAL OF NEUROSCIENCE

The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6

(2016) Alexander Küffer et al.   NATURE

Landscape of somatic mutations in 560 breast cancer whole-genome sequences

(2016) Serena Nik-Zainal et al.   NATURE

In vivo quantification of spatially varying mechanical properties in developing tissues

(2016) Friedhelm Serwane et al.   NATURE METHODS

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population

(2016) Jirouta Kitagaki et al.   PLoS One

Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation inMOCS3,IFIT3andSERPINA12

(2016) Victoria E Jackson et al.   THORAX

Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets

(2016) A Maiga et al.   Blood Cancer Journal

Mutations of GPR126 Are Responsible for Severe Arthrogryposis Multiplex Congenita

(2015) Gianina Ravenscroft et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2

(2015) Lilian M. Demberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Automated detection and quantification of single RNAs at cellular resolution in zebrafish embryos

(2015) L. Carine Stapel et al.   DEVELOPMENT

Association of GPR126 gene polymorphism with adolescent idiopathic scoliosis in Chinese populations

(2015) Ji-Feng Xu et al.   GENOMICS

Gpr126/Adgrg6deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice

(2015) Courtney M. Karner et al.   HUMAN MOLECULAR GENETICS

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequential Notch activation regulates ventricular chamber development

(2015) Gaetano D’Amato et al.   NATURE CELL BIOLOGY

The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211

(2015) Sarah C. Petersen et al.   NEURON

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

(2015) María Soler Artigas et al.   Nature Communications

New functions and signaling mechanisms for the class of adhesion G protein-coupled receptors

(2014) Ines Liebscher et al.   Annals of the New York Academy of Sciences

GPR126 Protein Regulates Developmental and Pathological Angiogenesis through Modulation of VEGFR2 Receptor Signaling

(2014) Hengxiang Cui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type IV collagen is an activating ligand for the adhesion G protein-coupled receptor GPR126

(2014) K. J. Paavola et al.   Science Signaling

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Analysis of Gpr126 function defines distinct mechanisms controlling the initiation and maturation of myelin

(2013) T. D. Glenn et al.   DEVELOPMENT

Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene

(2013) F.-S. Geng et al.   DEVELOPMENT

Gpr126 Functions in Schwann Cells to Control Differentiation and Myelination via G-Protein Activation

(2013) A. Mogha et al.   JOURNAL OF NEUROSCIENCE

Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis

(2013) Ikuyo Kou et al.   NATURE GENETICS

Organ-specific function of adhesion G protein-coupled receptor GPR126 is domain-dependent

(2013) C. Patra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Genome-Wide Association Studies IdentifyCHRNA5/3andHTR4in the Development of Airflow Obstruction

(2012) Jemma B. Wilk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Dissecting signaling and functions of adhesion G protein-coupled receptors

(2012) Demet Araç et al.   Annals of the New York Academy of Sciences

LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells

(2011) Y. Ward et al.   CANCER RESEARCH

Gpr126 is essential for peripheral nerve development and myelination in mammals

(2011) K. R. Monk et al.   DEVELOPMENT

The N Terminus of the Adhesion G Protein-coupled Receptor GPR56 Controls Receptor Signaling Activity

(2011) Kevin J. Paavola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature

(2010) Jianhua Zhao et al.   BMC Medical Genetics

Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing

(2010) Daisuke Okajima et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

The Orphan Adhesion-GPCR GPR126 Is Required for Embryonic Development in the Mouse

(2010) Helen Waller-Evans et al.   PLoS One

Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function

(2009) Dana B Hancock et al.   NATURE GENETICS

A G Protein-Coupled Receptor Is Essential for Schwann Cells to Initiate Myelination

(2009) K. R. Monk et al.   SCIENCE

Meta-Analysis of Genome-Wide Scans for Human Adult Stature Identifies Novel Loci and Associations with Measures of Skeletal Frame Size

(2009) Nicole Soranzo et al.   PLoS Genetics

Solution Structure and Sugar-Binding Mechanism of Mouse Latrophilin-1 RBL: a 7TM Receptor-Attached Lectin-Like Domain

(2008) Ioannis Vakonakis et al.   STRUCTURE