GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist

Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases

(2019) Christopher J. Folts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function

(2018) Oladapo E. Olaniru et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

GPR56/ADGRG1 regulates development and maintenance of peripheral myelin

(2018) Sarah D. Ackerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Gedunin- and Khivorin-Derivatives Are Small-Molecule Partial Agonists for Adhesion G Protein-Coupled Receptors GPR56/ADGRG1 and GPR114/ADGRG5

(2018) Hannah M. Stoveken et al.   MOLECULAR PHARMACOLOGY

Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells

(2018) Stefanie Giera et al.   eLife

Activation of Adhesion G Protein-coupled Receptors

(2017) Lilian M. Demberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region

(2017) Gabriel S. Salzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma

(2017) Marta Moreno et al.   Cell Reports

Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons

(2017) Nicole Scholz et al.   eLife

The Ecstasy and Agony of Assay Interference Compounds

(2017) Courtney Aldrich et al.   ACS Central Science

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo

(2016) C. Pabst et al.   BLOOD

Functional screen identifies regulators of murine hematopoietic stem cell repopulation

(2016) Per Holmfeldt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GPR56 contributes to the development of acute myeloid leukemia in mice

(2016) D Daria et al.   LEUKEMIA

Adhesion G protein-coupled receptors in nervous system development and disease

(2016) Tobias Langenhan et al.   NATURE REVIEWS NEUROSCIENCE

Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains

(2016) Gabriel S. Salzman et al.   NEURON

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

(2016) Gin-Wen Chang et al.   Cell Reports

Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1)

(2015) Ayush Kishore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development

(2015) Stefanie Giera et al.   Nature Communications

The adhesion GPCR Gpr56 regulates oligodendrocyte development via interactions with Gα12/13 and RhoA

(2015) Sarah D. Ackerman et al.   Nature Communications

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

Whole-transcriptome analysis of endothelial to hematopoietic stem cell transition reveals a requirement for Gpr56 in HSC generation

(2014) Parham Solaimani Kartalaei et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanism for Adhesion G Protein-Coupled Receptor GPR56-Mediated RhoA Activation Induced By Collagen III Stimulation

(2014) Rong Luo et al.   PLoS One

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

(2014) J. P. White et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolutionarily Dynamic Alternative Splicing of GPR56 Regulates Regional Cerebral Cortical Patterning

(2014) B.-I. Bae et al.   SCIENCE

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

GPR56 Inhibits Melanoma Growth by Internalizing and Degrading Its Ligand TG2

(2013) L. Yang et al.   CANCER RESEARCH

Maintenance of the hematopoietic stem cell pool in bone marrow niches by EVI1-regulated GPR56

(2013) Y Saito et al.   LEUKEMIA

GPR56 Functions Together with α3β1 Integrin in Regulating Cerebral Cortical Development

(2013) Sung-Jin Jeong et al.   PLoS One

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Disease-Associated Mutations Prevent GPR56-Collagen III Interaction

(2012) Rong Luo et al.   PLoS One

Loss of Col3a1, the Gene for Ehlers-Danlos Syndrome Type IV, Results in Neocortical Dyslamination

(2012) Sung-Jin Jeong et al.   PLoS One

G protein-coupled receptor 56 and collagen III, a receptor-ligand pair, regulates cortical development and lamination

(2011) R. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR56-related bilateral frontoparietal polymicrogyria: further evidence for an overlap with the cobblestone complex

(2010) Nadia Bahi-Buisson et al.   BRAIN

GPR56 is essential for testis development and male fertility in mice

(2010) Guangchun Chen et al.   DEVELOPMENTAL DYNAMICS

Regulation of Oligodendrocyte Differentiation and Myelination

(2010) B. Emery   SCIENCE

GPR56-Regulated Granule Cell Adhesion Is Essential for Rostral Cerebellar Development

(2009) S. Koirala et al.   JOURNAL OF NEUROSCIENCE

Regional Distribution of Cortical Interneurons and Development of Inhibitory Tone Are Regulated by Cxcl12/Cxcr4 Signaling

(2008) G. Li et al.   JOURNAL OF NEUROSCIENCE

Stoichiometry and Physical Chemistry of Promiscuous Aggregate-Based Inhibitors

(2008) Kristin E. D. Coan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Distinct Stages of Myelination Regulated by γ-Secretase and Astrocytes in a Rapidly Myelinating CNS Coculture System

(2008) Trent A. Watkins et al.   NEURON