Activation of Adhesion GPCR EMR2/ADGRE2 Induces Macrophage Differentiation and Inflammatory Responses via Gα16/Akt/MAPK/NF-κB Signaling Pathways

GPR56/ADGRG1 Activation Promotes Melanoma Cell Migration via NTF Dissociation and CTF-Mediated Gα 12/13 /RhoA Signaling

(2017) Nien-Yi Chiang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Phagocytosis: An Immunobiologic Process

(2016) Siamon Gordon   IMMUNITY

Vibratory Urticaria Associated with a Missense Variant in ADGRE2

(2016) Steven E. Boyden et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased EMR2 expression on neutrophils correlates with disease severity and predicts overall mortality in cirrhotic patients

(2016) Chien-Hao Huang et al.   Scientific Reports

The Adhesion G Protein-Coupled Receptor GPR56/ADGRG1 Is an Inhibitory Receptor on Human NK Cells

(2016) Gin-Wen Chang et al.   Cell Reports

Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation

(2015) S. M. Lewis et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Tethered agonists: a new mechanism underlying adhesion G protein-coupled receptor activation

(2015) Torsten Schöneberg et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Adhesion G protein-coupled receptors are activated by exposure of a cryptic tethered agonist

(2015) Hannah M. Stoveken et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How to wake a giant

(2015) Ines Liebscher et al.   Oncotarget

The Adhesion GPCR Latrophilin/CIRL Shapes Mechanosensation

(2015) Nicole Scholz et al.   Cell Reports

From the Reticuloendothelial to Mononuclear Phagocyte System – The Unaccounted Years

(2015) Simon Yona et al.   Frontiers in Immunology

CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity - role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments

(2014) Cheng-Chih Hsiao et al.   FEBS Journal

A Tethered Agonist within the Ectodomain Activates the Adhesion G Protein-Coupled Receptors GPR126 and GPR133

(2014) Ines Liebscher et al.   Cell Reports

Adhesion family of G protein-coupled receptors and cancer

(2014) Hsi-Hsien Lin   Biomedical Journal

Lysophosphatidylethanolamine utilizes LPA1 and CD97 in MDA-MB-231 breast cancer cells

(2013) Soo-Jin Park et al.   CELLULAR SIGNALLING

Shear Stress-Dependent Downregulation of the Adhesion-G Protein-Coupled Receptor CD97 on Circulating Leukocytes upon Contact with Its Ligand CD55

(2013) O. N. Karpus et al.   JOURNAL OF IMMUNOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis

(2012) Demet Araç et al.   EMBO JOURNAL

Signaling property study of adhesion G-protein-coupled receptors

(2012) Jamila Gupte et al.   FEBS LETTERS

Activation of Myeloid Cell-Specific Adhesion Class G Protein-Coupled Receptor EMR2 via Ligation-Induced Translocation and Interaction of Receptor Subunits in Lipid Raft Microdomains

(2012) Y.-S. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

LPA Receptor Heterodimerizes with CD97 to Amplify LPA-Initiated RHO-Dependent Signaling and Invasion in Prostate Cancer Cells

(2011) Y. Ward et al.   CANCER RESEARCH

F4/80 and the related adhesion-GPCRs

(2011) Siamon Gordon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease

(2010) Marco van Eijk et al.   IMMUNOLOGY LETTERS

The Identification of Markers of Macrophage Differentiation in PMA-Stimulated THP-1 Cells and Monocyte-Derived Macrophages

(2010) Marc Daigneault et al.   PLoS One

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Akt-dependent regulation of NF- B is controlled by mTOR and Raptor in association with IKK

(2008) H. C. Dan et al.   GENES & DEVELOPMENT

Adhesion-GPCRs: emerging roles for novel receptors

(2008) Simon Yona et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function

(2007) Simon Yona et al.   FASEB JOURNAL