Treating Bacterial Infections with Bacteriophage-Based Enzybiotics: In Vitro, In Vivo and Clinical Application

Development of a Novel Chimeric Endolysin, Lys109 With Enhanced Lytic Activity Against Staphylococcus aureus

(2021) Bokyung Son et al.   Frontiers in Microbiology

Bacteriophage-resistant Acinetobacter baumannii are resensitized to antimicrobials

(2021) Fernando Gordillo Altamirano et al.   Nature Microbiology

Engineered Phage Endolysin Eliminates Gardnerella Biofilm without Damaging Beneficial Bacteria in Bacterial Vaginosis Ex Vivo

(2021) Christine Landlinger et al.   Pathogens

A Novel Acinetobacter baumannii Bacteriophage Endolysin LysAB54 With High Antibacterial Activity Against Multiple Gram-Negative Microbes

(2021) Fazal Mehmood Khan et al.   Frontiers in Cellular and Infection Microbiology

Phage φAB6-Borne Depolymerase Combats Acinetobacter baumannii Biofilm Formation and Infection

(2021) Md. Shahed-Al-Mahmud et al.   Antibiotics-Basel

Phage-Encoded Endolysins

(2021) Fatma Abdelrahman et al.   Antibiotics-Basel

Application of bacteriophage-derived endolysins to combat streptococcal disease: current state and perspectives

(2021) Sara B Linden et al.   CURRENT OPINION IN BIOTECHNOLOGY

Targeting biofilms using phages and their enzymes

(2021) Joana Azeredo et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Advantages and Challenges of Using Endolysins in a Clinical Setting

(2021) Ellen Murray et al.   Viruses-Basel

Phage Endolysin LysP108 Showed Promising Antibacterial Potential Against Methicillin-resistant Staphylococcus aureus

(2021) Yifei Lu et al.   Frontiers in Cellular and Infection Microbiology

Molecular basis for recognition of the Group A Carbohydrate backbone by the PlyC streptococcal bacteriophage endolysin

(2021) Harley King et al.   BIOCHEMICAL JOURNAL

Application of bacteriophages and endolysins in aquaculture as a biocontrol measure

(2021) Ramesh Nachimuthu et al.   BIOLOGICAL CONTROL

Cloning and expression analysis of fused holin-endolysin from RL bacteriophage; Exhibits broad activity against multi drug resistant pathogens

(2021) Abdul Basit et al.   ENZYME AND MICROBIAL TECHNOLOGY

Endolysin LysSTG2: Characterization and application to control Salmonella Typhimurium biofilm alone and in combination with slightly acidic hypochlorous water

(2021) Yu Zhang et al.   FOOD MICROBIOLOGY

Phage Therapy in the 21st Century: Is There Modern, Clinical Evidence of Phage-Mediated Efficacy?

(2021) Stephen Abedon et al.   Pharmaceuticals

A Novel Tail-Associated O91-Specific Polysaccharide Depolymerase from Podophage Reveals Lytic Efficacy of Shiga Toxin-Producing E. coli

(2020) Yibao Chen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

TSPphg Lysin from the Extremophilic Thermus Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria

(2020) Feng Wang et al.   Viruses-Basel

Diversity and Function of Phage Encoded Depolymerases

(2020) Leandra E. Knecht et al.   Frontiers in Microbiology

In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens

(2020) Lucia Blasco et al.   Scientific Reports

Predicting Bacteriophage Enzymes and Hydrolases by Using Combined Features

(2020) Hong-Fei Li et al.   Frontiers in Bioengineering and Biotechnology

Modulation of Endolysin LysECD7 Bactericidal Activity by Different Peptide Tag Fusion

(2020) Nataliia P. Antonova et al.   Biomolecules

Bacteriophage-Derived Endolysins Applied as Potent Biocontrol Agents to Enhance Food Safety

(2020) Yoonjee Chang   Microorganisms

Bacteriophages and associated endolysins in therapy and prevention of mastitis and metritis in cows: Current knowledge

(2020) Sławomir Zduńczyk et al.   ANIMAL REPRODUCTION SCIENCE

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

(2020) Vance G. Fowler et al.   JOURNAL OF CLINICAL INVESTIGATION

Characterization of Endolysin LysECP26 Derived from rV5-like Phage vB_EcoM-ECP26 for Inactivation of Escherichia coli O157:H7

(2020) Do-Won Park et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

A VersaTile-driven platform for rapid hit-to-lead development of engineered lysins

(2020) H. Gerstmans et al.   Science Advances

The endolysin of the Acinetobacter baumannii phage vB_AbaP_D2 shows broad antibacterial activity

(2020) Yuyu Yuan et al.   Microbial Biotechnology

Encapsulation of the Antistaphylococcal Endolysin LysRODI in pH-Sensitive Liposomes

(2020) Silvia Portilla et al.   Antibiotics-Basel

Advanced engineering of third-generation lysins and formulation strategies for clinical applications

(2020) Vincent De Maesschalck et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Intravesical bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomised, placebo-controlled, double-blind clinical trial

(2020) Lorenz Leitner et al.   LANCET INFECTIOUS DISEASES

Bacteriophages: it's a medicine, Jim, but not as we know it

(2020) Jean-Paul Pirnay et al.   LANCET INFECTIOUS DISEASES

Characterization of a Lytic Bacteriophage vB_EfaS_PHB08 Harboring Endolysin Lys08 against Enterococcus faecalis Biofilms

(2020) Dan Yang et al.   Microorganisms

Bacillus-infecting bacteriophage Izhevsk harbors thermostable endolysin with broad range specificity

(2020) Anna V. Skorynina et al.   PLoS One

LysSAP26, a New Recombinant Phage Endolysin with a Broad Spectrum Antibacterial Activity

(2020) Shukho Kim et al.   Viruses-Basel

Lysins breaking down the walls of Gram-negative bacteria, no longer a no-go

(2020) Diana Gutiérrez et al.   CURRENT OPINION IN BIOTECHNOLOGY

Bacteriophage endolysins — extending their application to tissues and the bloodstream

(2020) Mathias Schmelcher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Phages to shape the gut microbiota?

(2020) Sofia Dahlman et al.   CURRENT OPINION IN BIOTECHNOLOGY

The Capsule Depolymerase Dpo48 Rescues Galleria mellonella and Mice From Acinetobacter baumannii Systemic Infections

(2019) Yannan Liu et al.   Frontiers in Microbiology

Broad Bactericidal Activity of the Myoviridae Bacteriophage Lysins LysAm24, LysECD7, and LysSi3 against Gram-Negative ESKAPE Pathogens

(2019) Nataliia Antonova et al.   Viruses-Basel

The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole

(2019) Karim Abdelkader et al.   Viruses-Basel

Protective and therapeutic application of the depolymerase derived from a novel KN1 genotype of Klebsiella pneumoniae bacteriophage in mice

(2019) Can Wang et al.   RESEARCH IN MICROBIOLOGY

In Vitro Activity of the Bacteriophage Endolysin HY-133 against Staphylococcus aureus Small-Colony Variants and Their Corresponding Wild Types

(2019) Nina Schleimer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The PlyB Endolysin of Bacteriophage vB_BanS_Bcp1 Exhibits Broad-Spectrum Bactericidal Activity against Bacillus cereus sensu lato Isolates

(2019) Raymond Schuch et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Postantibiotic and Sub-MIC Effects of Exebacase (Lysin CF-301) Enhance Antimicrobial Activity Against Staphylococcus aureus

(2019) Jun Taek Oh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis

(2019) Chiara Indiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophages, phage endolysins and antimicrobial peptides – the possibilities for their common use to combat infections and in the design of new drugs

(2019) Tomasz Mirski et al.   ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE

Lysocins: Bioengineered Antimicrobials That Deliver Lysins across the Outer Membrane of Gram-Negative Bacteria

(2019) Ryan D. Heselpoth et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Treatment with the Pseudomonas aeruginosa Glycoside Hydrolase PslG Combats Wound Infection by Improving Antibiotic Efficacy and Host Innate Immune Activity

(2019) Matthew J. Pestrak et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Characterization of the bacteriophage φEf11 ORF 28 endolysin: A multi-functional lytic enzyme with properties distinct from all other identified Enterococcus. faecalis phage endolysins

(2019) Hongming Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Endolysin treatment against Staphylococcus aureus in adults with atopic dermatitis: a randomized controlled trial

(2019) Jill de Wit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Bacteriophage Therapy of Chronic Nonhealing Wound: Clinical Study

(2019) Pooja Gupta et al.   International Journal of Lower Extremity Wounds

Emerging Strategies to Combat ESKAPE Pathogens in the Era of Antimicrobial Resistance: A Review

(2019) Mansura S. Mulani et al.   Frontiers in Microbiology

Phage-encoded K2 capsule depolymerase is highly stable, refractory to resistance and protects larvae and mice from Acinetobacter baumannii sepsis

(2019) Hugo Oliveira et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Non-traditional Antibacterial Therapeutic Options and Challenges

(2019) Ursula Theuretzbacher et al.   Cell Host & Microbe

Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends

(2019) Aleksi J. Hendricks et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Bacteriophages as adjuvant to antibiotics for the treatment of periprosthetic joint infection caused by multidrug-resistant Pseudomonas aeruginosa

(2019) Tamta Tkhilaishvili et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Non-antibiotic microbial solutions for bovine mastitis – live biotherapeutics, bacteriophage, and phage lysins

(2019) Angeliki Angelopoulou et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Inhibition of L. monocytogenes Biofilm Formation by the Amidase Domain of the Phage vB_LmoS_293 Endolysin

(2019) Pennone et al.   Viruses-Basel

Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Synergistic Activity of Exebacase (CF-301) in Addition to Daptomycin against Staphylococcus aureus in a Neutropenic Murine Thigh Infection Model

(2019) Tomefa E. Asempa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Biological challenges of phage therapy and proposed solutions: a literature review

(2019) Katherine M Caflisch et al.   Expert Review of Anti-Infective Therapy

Dendronized Silver Nanoparticles as Bacterial Membrane Permeabilizers and Their Interactions With P. aeruginosa Lipopolysaccharides, Lysozymes, and Phage-Derived Endolysins

(2019) Karol Ciepluch et al.   Frontiers in Microbiology

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

(2018) Barbara Maciejewska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthetic biology of modular endolysins

(2018) Hans Gerstmans et al.   BIOTECHNOLOGY ADVANCES

Autolysin mediated adherence of Staphylococcus aureus with Fibronectin, Gelatin and Heparin

(2018) Chandni Porayath et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Short communication: Recombinant bacteriophage endolysin PlyC is nontoxic and does not alter blood neutrophil oxidative response in lactating dairy cows

(2018) C.M. Scholte et al.   JOURNAL OF DAIRY SCIENCE

Restoration of sensitivity of a diverse set of drug-resistant Staphylococcus clinical strains by bactericidal protein P128

(2018) Sandhya Nair et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Characterisation of the antibacterial properties of the recombinant phage endolysins AP50-31 and LysB4 as potent bactericidal agents against Bacillus anthracis

(2018) Sangjin Park et al.   Scientific Reports

Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme

(2018) Stephanie A. Ragland et al.   PLoS Pathogens

Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

(2018) Nak-Hyun Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage spanins: diversity, topological dynamics and gene convergence

(2018) Rohit Kongari et al.   BMC BIOINFORMATICS

Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus

(2018) Patricia Letrado et al.   Future Microbiology

Bacteriophage Sb-1 enhances antibiotic activity against biofilm, degrades exopolysaccharide matrix and targets persisters of Staphylococcus aureus

(2018) Tamta Tkhilaishvili et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Efficacy of chimeric ectolysin P128 in drug-resistant Staphylococcus aureus bacteraemia in mice

(2018) Shankaramurthy Channabasappa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Innovations for the treatment of a complex bone and joint infection due to XDR Pseudomonas aeruginosa including local application of a selected cocktail of bacteriophages

(2018) Tristan Ferry et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Catalytic diversity and cell wall binding repeats in the phage encoded endolysins

(2018) Sebastian S. Broendum et al.   MOLECULAR MICROBIOLOGY

Therapeutic Application of Bacteriophage PHB02 and Its Putative Depolymerase Against Pasteurella multocida Capsular Type A in Mice

(2018) Yibao Chen et al.   Frontiers in Microbiology

Bactericidal activity of bacteriophage endolysin HY-133 against Staphylococcus aureus in comparison to other antibiotics as determined by minimum bactericidal concentrations and time-kill analysis

(2018) Dennis Knaack et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Functional analysis and anti-virulent properties of a new depolymerase from a myovirus that infects Acinetobacter baumannii capsule K45

(2018) Hugo Oliveira et al.   JOURNAL OF VIROLOGY

Antibiotic Therapy Using Phage Depolymerases: Robustness Across a Range of Conditions

(2018) Han Lin et al.   Viruses-Basel

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

(2018) Marek Harhala et al.   Viruses-Basel

Antibiotic resistance: a rundown of a global crisis

(2018) Bilal Aslam et al.   Infection and Drug Resistance

Combination of endolysins and high pressure to inactivate Listeria monocytogenes

(2017) Tomas J. van Nassau et al.   FOOD MICROBIOLOGY

Characterization of a novel endolysin LysSA11 and its utility as a potent biocontrol agent against Staphylococcus aureus on food and utensils

(2017) Yoonjee Chang et al.   FOOD MICROBIOLOGY

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

(2017) Hollie Hathaway et al.   JOURNAL OF CONTROLLED RELEASE

Function of bacteriophage G7C esterase tailspike in host cell adsorption

(2017) Nikolai S. Prokhorov et al.   MOLECULAR MICROBIOLOGY

Ménage à trois in the human gut: interactions between host, bacteria and phages

(2017) Mohammadali Khan Mirzaei et al.   NATURE REVIEWS MICROBIOLOGY

Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: study protocol for a randomized controlled trial (MAAS trial)

(2017) Joan Totté et al.   Trials

Bacteriophage therapy to combat bacterial infections in poultry

(2017) Andrzej Wernicki et al.   Virology Journal

The Human Gut Phage Community and Its Implications for Health and Disease

(2017) Pilar Manrique et al.   Viruses-Basel

A Novel Chimeric Endolysin with Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus

(2017) Hamed Haddad Kashani et al.   Frontiers in Cellular and Infection Microbiology

Phages in the Human Body

(2017) Ferran Navarro et al.   Frontiers in Microbiology

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

(2017) Han Lin et al.   Frontiers in Microbiology

A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa

(2017) Mingquan Guo et al.   Frontiers in Microbiology

Highly potent antimicrobial modified peptides derived from the Acinetobacter baumannii phage endolysin LysAB2

(2017) Shih-Yi Peng et al.   Scientific Reports

The O-specific polysaccharide lyase from the phage LKA1 tailspike reduces Pseudomonas virulence

(2017) Tomasz Olszak et al.   Scientific Reports

Antibiofilm activity and synergistic inhibition ofS. aureusbiofilms by bactericidal protein P128 in combination with antibiotics

(2016) Sandhya Nair et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Artilysin Art-175 against Resistant and Persistent Acinetobacter baumannii

(2016) Valerie Defraine et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

DUF3380 Domain from a Salmonella Phage Endolysin Shows PotentN-Acetylmuramidase Activity

(2016) Lorena Rodríguez-Rubio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteriophage-encoded depolymerases: their diversity and biotechnological applications

(2016) Diana P. Pires et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

From endolysins to Artilysin(R)s: novel enzyme-based approaches to kill drug-resistant bacteria

(2016) H. Gerstmans et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period

(2016) Soo Youn Jun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Bacteriophage endolysins: applications for food safety

(2016) Mathias Schmelcher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1

(2016) Jindai Fan et al.   VETERINARY MICROBIOLOGY

Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5

(2016) Pengjuan Gong et al.   VIROLOGY

Capsule-Targeting Depolymerase, Derived from Klebsiella KP36 Phage, as a Tool for the Development of Anti-Virulent Strategy

(2016) Grażyna Majkowska-Skrobek et al.   Viruses-Basel

Mechanisms of Antimicrobial Resistance in ESKAPE Pathogens

(2016) Sirijan Santajit et al.   Biomed Research International

A bacteriophage endolysin that eliminates intracellular streptococci

(2016) Yang Shen et al.   eLife

Enhanced Antibacterial Activity of Acinetobacter baumannii Bacteriophage ØABP-01 Endolysin (LysABP-01) in Combination with Colistin

(2016) Rapee Thummeepak et al.   Frontiers in Microbiology

Structural and Enzymatic Characterization of ABgp46, a Novel Phage Endolysin with Broad Anti-Gram-Negative Bacterial Activity

(2016) Hugo Oliveira et al.   Frontiers in Microbiology

PHYPred: a tool for identifying bacteriophage enzymes and hydrolases

(2016) Hui Ding et al.   VIROLOGICA SINICA

Exogenous Lytic Activity of SPN9CC Endolysin Against Gram-Negative Bacteria

(2016) Jeong-A Lim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

‘Artilysation’ of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci

(2016) Lorena Rodríguez-Rubio et al.   Scientific Reports

Bacteriophage PBC1 and Its Endolysin as an Antimicrobial Agent against Bacillus cereus

(2015) Minsuk Kong et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Synergistic streptococcal phage λSA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis

(2015) Mathias Schmelcher et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Phage lytic proteins: biotechnological applications beyond clinical antimicrobials

(2015) Lorena Rodríguez-Rubio et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Bacteriophages and Phage-Derived Proteins – Application Approaches

(2015) Zuzanna Drulis-Kawa et al.   CURRENT MEDICINAL CHEMISTRY

A novel and highly specific phage endolysin cell wall binding domain for detection of Bacillus cereus

(2015) Minsuk Kong et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

(2015) Yves Briers et al.   Future Microbiology

Increasing the stability of the bacteriophage endolysin PlyC using rationale-based FoldX computational modeling

(2015) Ryan D. Heselpoth et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Quantitative analysis of the thermal stability of the gamma phage endolysin PlyG: A biophysical and kinetic approach to assaying therapeutic potential

(2015) Ryan D. Heselpoth et al.   VIROLOGY

Fighting sinus-derivedStaphylococcus aureusbiofilms in vitro with a bacteriophage-derived muralytic enzyme

(2015) Amanda J. Drilling et al.   International Forum of Allergy & Rhinology

Role of the Pre-neck Appendage Protein (Dpo7) from Phage vB_SepiS-phiIPLA7 as an Anti-biofilm Agent in Staphylococcal Species

(2015) Diana Gutiérrez et al.   Frontiers in Microbiology

Lysozyme as an alternative to growth promoting antibiotics in swine production

(2015) W. T. Oliver et al.   Journal of Animal Science and Biotechnology

Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa

(2014) Yves Briers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Preclinical Safety Evaluation of Intravenously Administered SAL200 Containing the Recombinant Phage Endolysin SAL-1 as a Pharmaceutical Ingredient

(2014) Soo Youn Jun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intravitreal Injection of the Chimeric Phage Endolysin Ply187 Protects Mice from Staphylococcus aureus Endophthalmitis

(2014) Pawan Kumar Singh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identification of Capsular Types in Carbapenem-Resistant Klebsiella pneumoniae Strains bywzcSequencing and Implications for Capsule Depolymerase Treatment

(2014) Yi-Jiun Pan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Microbial Exo-xylanases: A Mini Review

(2014) Veeresh Juturu et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Biochemical and biophysical characterization of PlyGRCS, a bacteriophage endolysin active against methicillin-resistant Staphylococcus aureus

(2014) Sara B. Linden et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Peptidoglycan degrading activity of the broad-range Salmonella bacteriophage S-394 recombinant endolysin

(2014) Sergey A. Legotsky et al.   BIOCHIMIE

Saccharomyces cerevisiae expressing bacteriophage endolysins reduce Lactobacillus contamination during fermentation

(2014) Piyum A Khatibi et al.   Biotechnology for Biofuels

Antibacterial properties of Acinetobacter baumanniiphage Abp1 endolysin (PlyAB1)

(2014) Guangtao Huang et al.   BMC INFECTIOUS DISEASES

Functional elucidation of antibacterial phage ORFans targetingPseudomonas aeruginosa

(2014) Jeroen Wagemans et al.   CELLULAR MICROBIOLOGY

Bacteriophages and their Enzymes in Biofilm Control

(2014) Benjamin Chan et al.   CURRENT PHARMACEUTICAL DESIGN

The Prophage-encoded Hyaluronate Lyase Has Broad Substrate Specificity and Is Regulated by the N-terminal Domain

(2014) Sudhir Kumar Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phage lysis: Three steps, three choices, one outcome

(2014) Ryland Young   JOURNAL OF MICROBIOLOGY

Application ofLactobacillus johnsoniiexpressing phage endolysin for control ofClostridium perfringens

(2014) T. Gervasi et al.   LETTERS IN APPLIED MICROBIOLOGY

Bacteriophage-derived CHAP domain protein, P128, kills Staphylococcus cells by cleaving interpeptide cross-bridge of peptidoglycan

(2014) S. Sundarrajan et al.   MICROBIOLOGY-SGM

X-ray structure of a novel endolysin encoded by episomal phage phiSM101 ofClostridium perfringens

(2014) Eiji Tamai et al.   MOLECULAR MICROBIOLOGY

Effective Removal of Staphylococcal Biofilms by the Endolysin LysH5

(2014) Diana Gutiérrez et al.   PLoS One

A Thermostable Salmonella Phage Endolysin, Lys68, with Broad Bactericidal Properties against Gram-Negative Pathogens in Presence of Weak Acids

(2014) Hugo Oliveira et al.   PLoS One

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

The CD27L and CTP1L Endolysins Targeting Clostridia Contain a Built-in Trigger and Release Factor

(2014) Matthew Dunne et al.   PLoS Pathogens

Improving the Lethal Effect of Cpl-7, a Pneumococcal Phage Lysozyme with Broad Bactericidal Activity, by Inverting the Net Charge of Its Cell Wall-Binding Module

(2013) Roberto Díez-Martínez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage Polysaccharide Depolymerases and Biomedical Applications

(2013) Jianlong Yan et al.   BIODRUGS

Bacteriophage-encoded lytic enzymes control growth of contaminating Lactobacillus found in fuel ethanol fermentations

(2013) Dwayne R Roach et al.   Biotechnology for Biofuels

Learning from Bacteriophages - Advantages and Limitations of Phage and Phage-Encoded Protein Applications

(2013) Zuzanna Drulis-Kawa et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

The tail-associated depolymerase ofErwinia amylovoraphage L1 mediates host cell adsorption and enzymatic capsule removal, which can enhance infection by other phage

(2013) Yannick Born et al.   ENVIRONMENTAL MICROBIOLOGY

Bactericidal synergism between daptomycin and the phage lysin Cpl-1 in a mouse model of pneumococcal bacteraemia

(2013) Jacques Vouillamoz et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Rapid degradation of Streptococcus pyogenes biofilms by PlyC, a bacteriophage-encoded endolysin

(2013) Yang Shen et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Aeromonas punctataderived depolymerase that disrupts the integrity ofKlebsiella pneumoniaecapsule: optimization of depolymerase production

(2013) Shruti Bansal et al.   JOURNAL OF BASIC MICROBIOLOGY

Combination Therapy With Lysin CF-301 and Antibiotic Is Superior to Antibiotic Alone for Treating Methicillin-Resistant Staphylococcus aureus–Induced Murine Bacteremia

(2013) Raymond Schuch et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

(2013) H. Oliveira et al.   JOURNAL OF VIROLOGY

Potential of the Virion-Associated Peptidoglycan Hydrolase HydH5 and Its Derivative Fusion Proteins in Milk Biopreservation

(2013) Lorena Rodríguez-Rubio et al.   PLoS One

Hurdles in bacteriophage therapy: Deconstructing the parameters

(2013) Jessica Tsonos et al.   VETERINARY MICROBIOLOGY

Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications

(2013) Raghu Patil Junjappa et al.   VETERINARY RESEARCH COMMUNICATIONS

Rethinking Antibiotic Research and Development: World War II and the Penicillin Collaborative

(2012) Roswell Quinn   AMERICAN JOURNAL OF PUBLIC HEALTH

Chimeric Phage Lysins Act Synergistically with Lysostaphin To Kill Mastitis-Causing Staphylococcus aureus in Murine Mammary Glands

(2012) Mathias Schmelcher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Enhanced Staphylolytic Activity of the Staphylococcus aureus Bacteriophage vB_SauS-phiIPLA88 HydH5 Virion-Associated Peptidoglycan Hydrolase: Fusions, Deletions, and Synergy with LysH5

(2012) Lorena Rodríguez-Rubio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Characterization of five novel endolysins from Gram-negative infecting bacteriophages

(2012) Maarten Walmagh et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antistaphylococcal activity of bacteriophage derived chimeric protein P128

(2012) Aradhana A Vipra et al.   BMC MICROBIOLOGY

Bacteriophage virion-associated peptidoglycan hydrolases: potential new enzybiotics

(2012) Lorena Rodríguez-Rubio et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Isolation and lytic activity of the Listeria bacteriophage endolysin LysZ5 against Listeria monocytogenes in soya milk

(2012) Hui Zhang et al.   FOOD MICROBIOLOGY

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Introducing yesterday’s phage therapy in today’s medicine

(2012) Jean-Paul Pirnay et al.   Future Virology

Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1

(2012) Soo Youn Jun et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Bacteriocins — a viable alternative to antibiotics?

(2012) Paul D. Cotter et al.   NATURE REVIEWS MICROBIOLOGY

Mycobacteriophage Endolysins: Diverse and Modular Enzymes with Multiple Catalytic Activities

(2012) Kimberly M. Payne et al.   PLoS One

Characterization of Modular Bacteriophage Endolysins from Myoviridae Phages OBP, 201φ2-1 and PVP-SE1

(2012) Maarten Walmagh et al.   PLoS One

Structural engineering of a phage lysin that targets Gram-negative pathogens

(2012) P. Lukacik et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of endolysin from a Salmonella Typhimurium-infecting bacteriophage SPN1S

(2012) Jeong-A. Lim et al.   RESEARCH IN MICROBIOLOGY

Identification of EPS-degrading activity within the tail spikes of the novel Pseudomonas putida phage AF

(2012) Anneleen Cornelissen et al.   VIROLOGY

In VitroDestruction of Streptococcus pneumoniae Biofilms with Bacterial and Phage Peptidoglycan Hydrolases

(2011) Mirian Domenech et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Comparison of the Antibacterial Properties of Phage Endolysins SAL-1 and LysK

(2011) Soo Youn Jun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Features and applications of bacterial sialidases

(2011) Seonghun Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antibacterial activity of Acinetobacter baumannii phage ϕAB2 endolysin (LysAB2) against both Gram-positive and Gram-negative bacteria

(2011) Meng-Jiun Lai et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Necrotic enteritis in broilers: an updated review on the pathogenesis

(2011) L. Timbermont et al.   AVIAN PATHOLOGY

Microbial xylanases: Engineering, production and industrial applications

(2011) Veeresh Juturu et al.   BIOTECHNOLOGY ADVANCES

Alginate lyase: Structure, property, and application

(2011) Hee Sook Kim et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

A novel bacteriophage Tail-Associated Muralytic Enzyme (TAME) from Phage K and its development into a potent antistaphylococcal protein

(2011) Vivek Paul et al.   BMC MICROBIOLOGY

P-27/HP Endolysin as Antibacterial Agent for Antibiotic Resistant Staphylococcus aureus of Human Infections

(2011) Ragini Gupta et al.   CURRENT MICROBIOLOGY

Use of bacteriophage endolysin EL188 and outer membrane permeabilizers against Pseudomonas aeruginosa

(2011) Y. Briers et al.   JOURNAL OF APPLIED MICROBIOLOGY

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Bacillus subtilis σ V Confers Lysozyme Resistance by Activation of Two Cell Wall Modification Pathways, Peptidoglycan O-Acetylation and d-Alanylation of Teichoic Acids

(2011) Veronica Guariglia-Oropeza et al.   JOURNAL OF BACTERIOLOGY

The T7-Related Pseudomonas putida Phage φ15 Displays Virion-Associated Biofilm Degradation Properties

(2011) Anneleen Cornelissen et al.   PLoS One

PEGylating a bacteriophage endolysin inhibits its bactericidal activity

(2011) Gregory Resch et al.   AMB Express

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Novel Chimeric Lysin Shows Superiority to Mupirocin for Skin Decolonization of Methicillin-Resistant and -SensitiveStaphylococcus aureusStrains

(2010) Mina Pastagia et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The perspectives of the application of phage therapy in chronic bacterial prostatitis

(2010) Sławomir Letkiewicz et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Modifications to the Peptidoglycan Backbone Help Bacteria To Establish Infection

(2010) Kimberly M. Davis et al.   INFECTION AND IMMUNITY

Synergy between the phage endolysin LysH5 and nisin to kill Staphylococcus aureus in pasteurized milk

(2010) Pilar García et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens

(2010) Vincent A. Fischetti   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

LysGH15, a Novel Bacteriophage Lysin, Protects a Murine Bacteremia Model Efficiently against Lethal Methicillin-Resistant Staphylococcus aureus Infection

(2010) J. Gu et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Characterization of Staphylococcus aureus derived from bovine mastitis and isolation of two lytic bacteriophages

(2010) Jee Soo Son et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

Pathogen-Associated Molecular Pattern-Triggered Immunity: Veni, Vidi...?

(2010) C. Zipfel et al.   PLANT PHYSIOLOGY

Orally Administered P22 Phage Tailspike Protein Reduces Salmonella Colonization in Chickens: Prospects of a Novel Therapy against Bacterial Infections

(2010) Shakeeba Waseh et al.   PLoS One

α-l-Rhamnosidase: A review

(2010) Vinita Yadav et al.   PROCESS BIOCHEMISTRY

Food biopreservation: promising strategies using bacteriocins, bacteriophages and endolysins

(2010) Pilar García et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

Use of a Bacteriophage Lysin, PlyC, as an Enzyme Disinfectant against Streptococcus equi

(2009) J. T. Hoopes et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144

(2009) Yves Briers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The use of antibiotics to improve phage detection and enumeration by the double-layer agar technique

(2009) Sílvio B Santos et al.   BMC MICROBIOLOGY

Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia*

(2009) Martin Witzenrath et al.   CRITICAL CARE MEDICINE

Purified Recombinant Phage Lysin LySMP: An Extensive Spectrum of Lytic Activity for Swine Streptococci

(2009) Y. Wang et al.   CURRENT MICROBIOLOGY

Nasal Delivery of High Molecular Weight Drugs

(2009) Yıldız Ozsoy et al.   MOLECULES

Dextranase in sugar industry: A review

(2009) Efraín Rodríguez Jiménez   Sugar Tech

The Use of Phages for the Removal of Infectious Biofilms

(2008) J. Azeredo et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The phage K lytic enzyme LysK and lysostaphin act synergistically to kill MRSA

(2008) Stephen C. Becker et al.   FEMS MICROBIOLOGY LETTERS

Lytic activity of the recombinant staphylococcal bacteriophage ΦH5 endolysin active against Staphylococcus aureus in milk

(2008) José María Obeso et al.   INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY

A list of enzyme preparations covered by the term enzybiotics should not be restricted to bacteriophage-encoded peptidoglycan hydrolases (lysins)

(2008) Gediminas A. Biziulevičius et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Phage therapy experience at the Eliava Institute

(2008) M. Kutateladze et al.   MEDECINE ET MALADIES INFECTIEUSES

Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae

(2008) Kimberly M. Davis et al.   PLoS Pathogens