Phage-Encoded Endolysins

Construction and characterization of a chimeric lysin ClyV with improved bactericidal activity against Streptococcus agalactiae in vitro and in vivo

(2020) Li Huang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

(2020) Monika Reuter et al.   VIRUS GENES

Antimicrobial activity of LysSS, a novel phage endolysin, against Acinetobacter baumannii and Pseudomonas aeruginosa

(2020) Shukho Kim et al.   Journal of Global Antimicrobial Resistance

Structural and functional insights into a novel two-component endolysin encoded by a single gene in Enterococcus faecalis phage

(2020) Biao Zhou et al.   PLoS Pathogens

Phages for Biofilm Removal

(2020) Celia Ferriol-González et al.   Antibiotics-Basel

The Principles, Mechanisms, and Benefits of Unconventional Agents in the Treatment of Biofilm Infection

(2020) Jasminka Talapko et al.   Pharmaceuticals

Towards Inhaled Phage Therapy in Western Europe

(2019) Sandra-Maria Wienhold et al.   Viruses-Basel

The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole

(2019) Karim Abdelkader et al.   Viruses-Basel

The Concept of an Ideal Antibiotic: Implications for Drug Design

(2019) Márió Gajdács   MOLECULES

Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection

(2019) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Advantages and Limitations of Bacteriophages for the Treatment of Bacterial Infections

(2019) Nicola Principi et al.   Frontiers in Pharmacology

Non-traditional Antibacterial Therapeutic Options and Challenges

(2019) Ursula Theuretzbacher et al.   Cell Host & Microbe

Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo

(2019) Ichiro Imanishi et al.   Viruses-Basel

Linker editing of pneumococcal lysin ClyJ conveys improved bactericidal activity

(2019) Hang Yang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endolysins as emerging alternative therapeutic agent to counter drug resistant infections.

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Comprehensive evaluation of chitosan nanoparticle based phage lysin delivery system; a novel approach to counter S. pneumoniae infections

(2019) Vijay Singh Gondil et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Methicillin-Resistant Staphylococcus aureus in Hospitals: Latest Trends and Treatments Based on Bacteriophages

(2019) Andrea Álvarez et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Applications of bacteriophages versus phage enzymes to combat and cure bacterial infections: an ambitious and also a realistic application?

(2018) Barbara Maciejewska et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Synthetic biology of modular endolysins

(2018) Hans Gerstmans et al.   BIOTECHNOLOGY ADVANCES

Phage-derived lysins as potential agents for eradicating biofilms and persisters

(2018) Umender Sharma et al.   DRUG DISCOVERY TODAY

The Developmental Switch in Bacteriophage λ: A Critical Role of the Cro Protein

(2018) Sangmi Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Phage-Derived Peptidoglycan Degrading Enzymes: Challenges and Future Prospects for In Vivo Therapy

(2018) Hugo Oliveira et al.   Viruses-Basel

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

(2018) Vincent Fischetti   Viruses-Basel

Resistance Development to Bacteriophages Occurring during Bacteriophage Therapy

(2018) Frank Oechslin   Viruses-Basel

Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus?

(2018) Diana Gutiérrez et al.   mBio

Effects of Phage Endolysin SAL200 Combined with Antibiotics on Staphylococcus aureus Infection

(2018) Nak-Hyun Kim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bactericidal synergism between antibiotics and phage endolysin Cpl-711 to kill multidrug-resistant pneumococcus

(2018) Patricia Letrado et al.   Future Microbiology

Combination of endolysins and high pressure to inactivate Listeria monocytogenes

(2017) Tomas J. van Nassau et al.   FOOD MICROBIOLOGY

Characterization of a novel endolysin LysSA11 and its utility as a potent biocontrol agent against Staphylococcus aureus on food and utensils

(2017) Yoonjee Chang et al.   FOOD MICROBIOLOGY

Thermally triggered release of the bacteriophage endolysin CHAPK and the bacteriocin lysostaphin for the control of methicillin resistant Staphylococcus aureus (MRSA)

(2017) Hollie Hathaway et al.   JOURNAL OF CONTROLLED RELEASE

Targeting microbial biofilms: current and prospective therapeutic strategies

(2017) Hyun Koo et al.   NATURE REVIEWS MICROBIOLOGY

Bacteriophage therapy to combat bacterial infections in poultry

(2017) Andrzej Wernicki et al.   Virology Journal

A Novel Antimicrobial Endolysin, LysPA26, against Pseudomonas aeruginosa

(2017) Mingquan Guo et al.   Frontiers in Microbiology

The Human Microbiota in Health and Disease

(2017) Baohong Wang et al.   Engineering

Endolysin LysEF-P10 shows potential as an alternative treatment strategy for multidrug-resistant Enterococcus faecalis infections

(2017) Mengjun Cheng et al.   Scientific Reports

DUF3380 Domain from a Salmonella Phage Endolysin Shows PotentN-Acetylmuramidase Activity

(2016) Lorena Rodríguez-Rubio et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Chimeric LysK-Lysostaphin Fusion Enzyme Lysing Staphylococcus aureus Cells: a Study of Both Kinetics of Inactivation and Specifics of Interaction with Anionic Polymers

(2016) Lyubov Y. Filatova et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Assessing the Immunogenicity of Biopharmaceuticals

(2016) Carlos Pineda et al.   BIODRUGS

Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period

(2016) Soo Youn Jun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Bacteriophage endolysins: applications for food safety

(2016) Mathias Schmelcher et al.   CURRENT OPINION IN BIOTECHNOLOGY

Preliminary treatment of bovine mastitis caused by Staphylococcus aureus, with trx-SA1, recombinant endolysin of S. aureus bacteriophage IME-SA1

(2016) Jindai Fan et al.   VETERINARY MICROBIOLOGY

Enhanced Antibacterial Activity of Acinetobacter baumannii Bacteriophage ØABP-01 Endolysin (LysABP-01) in Combination with Colistin

(2016) Rapee Thummeepak et al.   Frontiers in Microbiology

Triple-acting Lytic Enzyme Treatment of Drug-Resistant and Intracellular Staphylococcus aureus

(2016) Stephen C. Becker et al.   Scientific Reports

LysGH15 kills Staphylococcus aureus without being affected by the humoral immune response or inducing inflammation

(2016) Lei Zhang et al.   Scientific Reports

‘Artilysation’ of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci

(2016) Lorena Rodríguez-Rubio et al.   Scientific Reports

Novel Phage Lysin Capable of Killing the Multidrug-Resistant Gram-Negative Bacterium Acinetobacter baumannii in a Mouse Bacteremia Model

(2015) Rolf Lood et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage lytic proteins: biotechnological applications beyond clinical antimicrobials

(2015) Lorena Rodríguez-Rubio et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Evolutionarily distinct bacteriophage endolysins featuring conserved peptidoglycan cleavage sites protect mice from MRSA infection

(2015) Mathias Schmelcher et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Insights into the regulation of bacteriophage endolysin: multiple means to the same end

(2015) Amol Arunrao Pohane et al.   MICROBIOLOGY-SGM

Battling Phages: How Bacteria Defend against Viral Attack

(2015) Kimberley D. Seed   PLoS Pathogens

Antibacterial Activity of a Novel Peptide-Modified Lysin Against Acinetobacter baumannii and Pseudomonas aeruginosa

(2015) Hang Yang et al.   Frontiers in Microbiology

A chimeolysin with extended-spectrum streptococcal host range found by an induced lysis-based rapid screening method

(2015) Hang Yang et al.   Scientific Reports

Effects of Antibiotics on Human Microbiota and Subsequent Disease

(2014) Kristie M. Keeney et al.   Annual Review of Microbiology

Preclinical Safety Evaluation of Intravenously Administered SAL200 Containing the Recombinant Phage Endolysin SAL-1 as a Pharmaceutical Ingredient

(2014) Soo Youn Jun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Highly Active and Negatively Charged Streptococcus pyogenes Lysin with a Rare d-Alanyl-l-Alanine Endopeptidase Activity Protects Mice against Streptococcal Bacteremia

(2014) Rolf Lood et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Application ofLactobacillus johnsoniiexpressing phage endolysin for control ofClostridium perfringens

(2014) T. Gervasi et al.   LETTERS IN APPLIED MICROBIOLOGY

X-ray structure of a novel endolysin encoded by episomal phage phiSM101 ofClostridium perfringens

(2014) Eiji Tamai et al.   MOLECULAR MICROBIOLOGY

Rod-like bacterial shape is maintained by feedback between cell curvature and cytoskeletal localization

(2014) T. S. Ursell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Improving the Lethal Effect of Cpl-7, a Pneumococcal Phage Lysozyme with Broad Bactericidal Activity, by Inverting the Net Charge of Its Cell Wall-Binding Module

(2013) Roberto Díez-Martínez et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroCharacterization of PlySK1249, a Novel Phage Lysin, and Assessment of Its Antibacterial Activity in a Mouse Model of Streptococcus agalactiae Bacteremia

(2013) Frank Oechslin et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The secondary cell wall polysaccharide of Bacillus anthracis provides the specific binding ligand for the C-terminal cell wall-binding domain of two phage endolysins, PlyL and PlyG

(2013) J. Ganguly et al.   GLYCOBIOLOGY

Delivery of the endolysin Cpl-1 by inhalation rescues mice with fatal pneumococcal pneumonia

(2013) J. M. Doehn et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Lysins: the arrival of pathogen-directed anti-infectives

(2013) M. Pastagia et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Lysis Delay and Burst Shrinkage of Coliphage T7 by Deletion of Terminator T  Reversed by Deletion of Early Genes

(2013) H. M. Nguyen et al.   JOURNAL OF VIROLOGY

Molecular Aspects and Comparative Genomics of Bacteriophage Endolysins

(2013) H. Oliveira et al.   JOURNAL OF VIROLOGY

Functional requirements for bacteriophage growth: gene essentiality and expression in mycobacteriophage Giles

(2013) Rebekah M. Dedrick et al.   MOLECULAR MICROBIOLOGY

Sources of Antimicrobial Resistance

(2013) M. E. J. Woolhouse et al.   SCIENCE

Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma: potential applications

(2013) Raghu Patil Junjappa et al.   VETERINARY RESEARCH COMMUNICATIONS

A brief multi-disciplinary review on antimicrobial resistance in medicine and its linkage to the global environmental microbiota

(2013) L. Cantas et al.   Frontiers in Microbiology

Chimeric Phage Lysins Act Synergistically with Lysostaphin To Kill Mastitis-Causing Staphylococcus aureus in Murine Mammary Glands

(2012) Mathias Schmelcher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Protection against human papillomavirus type 16-induced tumors in mice using non-genetically modified lactic acid bacteria displaying E7 antigen at its surface

(2012) Pedro Ribelles et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Antistaphylococcal activity of bacteriophage derived chimeric protein P128

(2012) Aradhana A Vipra et al.   BMC MICROBIOLOGY

Isolation and lytic activity of the Listeria bacteriophage endolysin LysZ5 against Listeria monocytogenes in soya milk

(2012) Hui Zhang et al.   FOOD MICROBIOLOGY

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Antibacterial properties of a pre-formulated recombinant phage endolysin, SAL-1

(2012) Soo Youn Jun et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

A conformational switch controls cell wall-remodelling enzymes required for bacterial cell division

(2012) Desirée C. Yang et al.   MOLECULAR MICROBIOLOGY

Mycobacteriophage Endolysins: Diverse and Modular Enzymes with Multiple Catalytic Activities

(2012) Kimberly M. Payne et al.   PLoS One

Interaction of fishes with pathogenic micro-organisms and application of phages for their control: a review

(2012) Swapnil G. Sanmukh et al.   REVIEWS IN FISH BIOLOGY AND FISHERIES

Comparison of the Antibacterial Properties of Phage Endolysins SAL-1 and LysK

(2011) Soo Youn Jun et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Application of a Bacteriophage Lysin To Disrupt Biofilms Formed by the Animal Pathogen Streptococcus suis

(2011) Xiangpeng Meng et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Necrotic enteritis in broilers: an updated review on the pathogenesis

(2011) L. Timbermont et al.   AVIAN PATHOLOGY

Food Animals and Antimicrobials: Impacts on Human Health

(2011) B. M. Marshall et al.   CLINICAL MICROBIOLOGY REVIEWS

Structure-Based Modification of a Clostridium difficile-Targeting Endolysin Affects Activity and Host Range

(2011) M. J. Mayer et al.   JOURNAL OF BACTERIOLOGY

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Synergism between a Novel Chimeric Lysin and Oxacillin Protects against Infection by Methicillin-Resistant Staphylococcus aureus

(2010) A. Daniel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Identifying Active Phage Lysins through Functional Viral Metagenomics

(2010) J. E. Schmitz et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens

(2010) Vincent A. Fischetti   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Complicated skin and soft tissue infection

(2010) M. S. Dryden   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Regulation of a Phage Endolysin by Disulfide Caging

(2010) G. F. Kuty et al.   JOURNAL OF BACTERIOLOGY

Cpl-7, a Lysozyme Encoded by a Pneumococcal Bacteriophage with a Novel Cell Wall-binding Motif

(2010) Noemí Bustamante et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal Regulation of Gene Expression of the Thermus thermophilus Bacteriophage P23-45

(2010) Zhanna Berdygulova et al.   JOURNAL OF MOLECULAR BIOLOGY

The Phage Therapy Paradigm: Prêt-à-Porter or Sur-mesure?

(2010) Jean-Paul Pirnay et al.   PHARMACEUTICAL RESEARCH

Use of a Bacteriophage Lysin, PlyC, as an Enzyme Disinfectant against Streptococcus equi

(2009) J. T. Hoopes et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Antibacterial and biofilm removal activity of a podoviridae Staphylococcus aureus bacteriophage SAP-2 and a derived recombinant cell-wall-degrading enzyme

(2009) Jee-Soo Son et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The high-affinity peptidoglycan binding domain of Pseudomonas phage endolysin KZ144

(2009) Yves Briers et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia*

(2009) Martin Witzenrath et al.   CRITICAL CARE MEDICINE

Purified Recombinant Phage Lysin LySMP: An Extensive Spectrum of Lytic Activity for Swine Streptococci

(2009) Y. Wang et al.   CURRENT MICROBIOLOGY

Current insights into phage biodiversity and biogeography

(2009) Rebecca Vega Thurber   CURRENT OPINION IN MICROBIOLOGY

Industrial Food Animal Production, Antimicrobial Resistance, and Human Health

(2008) Ellen K. Silbergeld et al.   Annual Review of Public Health

Bacteriophage lysins as effective antibacterials

(2008) Vincent A Fischetti   CURRENT OPINION IN MICROBIOLOGY

The phage K lytic enzyme LysK and lysostaphin act synergistically to kill MRSA

(2008) Stephen C. Becker et al.   FEMS MICROBIOLOGY LETTERS

Phage Lytic Enzyme Cpl‐1 for Antibacterial Therapy in Experimental Pneumococcal Meningitis

(2008) Denis Grandgirard et al.   JOURNAL OF INFECTIOUS DISEASES