Bacteriophage endolysins — extending their application to tissues and the bloodstream

TSPphg Lysin from the Extremophilic Thermus Bacteriophage TSP4 as a Potential Antimicrobial Agent against Both Gram-Negative and Gram-Positive Pathogenic Bacteria

(2020) Feng Wang et al.   Viruses-Basel

Phage Lytic Protein LysRODI Prevents Staphylococcal Mastitis in Mice

(2020) Diana Gutiérrez et al.   Frontiers in Microbiology

Staphylococcus aureus persistence properties associated with bovine mastitis and alternative therapeutic modalities

(2020) Nawel Zaatout et al.   JOURNAL OF APPLIED MICROBIOLOGY

Antibiofilm Activity of a Broad-Range Recombinant Endolysin LysECD7: In Vitro and In Vivo Study

(2020) Mikhail V. Fursov et al.   Viruses-Basel

Targeting Hidden Pathogens: Cell-Penetrating Enzybiotics Eradicate Intracellular Drug-Resistant Staphylococcus aureus

(2020) Christian Röhrig et al.   mBio

In vitro and in vivo efficacy of combinations of colistin and different endolysins against clinical strains of multi-drug resistant pathogens

(2020) Lucia Blasco et al.   Scientific Reports

Exebacase for patients with Staphylococcus aureus bloodstream infection and endocarditis

(2020) Vance G. Fowler et al.   JOURNAL OF CLINICAL INVESTIGATION

Engineering of Long-Circulating Peptidoglycan Hydrolases Enables Efficient Treatment of Systemic Staphylococcus aureus Infection

(2020) Anna M. Sobieraj et al.   mBio

A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment of Clostridioides difficile Infection in Mice

(2019) Zhong Peng et al.   Frontiers in Microbiology

Lysis of Staphylococcal Cells by Modular Lysin Domains Linked via a Non-covalent Barnase-Barstar Interaction Bridge

(2019) Linnea C. Hjelm et al.   Frontiers in Microbiology

The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole

(2019) Karim Abdelkader et al.   Viruses-Basel

Postantibiotic and Sub-MIC Effects of Exebacase (Lysin CF-301) Enhance Antimicrobial Activity Against Staphylococcus aureus

(2019) Jun Taek Oh et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Antistaphylococcal Lysin, CF-301, Activates Key Host Factors in Human Blood To Potentiate Methicillin-Resistant Staphylococcus aureus Bacteriolysis

(2019) Chiara Indiani et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Efficacy of Intranasal Administration of the Recombinant Endolysin SAL200 in a Lethal Murine Staphylococcus aureus Pneumonia Model

(2019) Ji Yun Bae et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Isolation of phage lysins that effectively kill Pseudomonas aeruginosa in mouse models of lung and skin infection

(2019) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Endolysin treatment against Staphylococcus aureus in adults with atopic dermatitis: a randomized controlled trial

(2019) Jill de Wit et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Influence of Dimerization on the Pharmacokinetics and Activity of an Antibacterial Enzyme Lysostaphin

(2019) Alexander V. Grishin et al.   MOLECULES

Bioactive Silk Coatings Reduce the Adhesion of Staphylococcus aureus while Supporting Growth of Osteoblast-like Cells

(2019) Linnea Nilebäck et al.   ACS Applied Materials & Interfaces

Exebacase in Addition to Daptomycin is More Active than Daptomycin or Exebacase Alone in Methicillin-Resistant Staphylococcus aureus Osteomyelitis in Rats

(2019) Melissa J. Karau et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synergy Between Two Chimeric Lysins to Kill Streptococcus pneumoniae

(2019) Roberto Vázquez et al.   Frontiers in Microbiology

Modular Assembly of Unique Chimeric Lytic Enzymes on a Protein Scaffold Possessing Anti-Staphylococcal Activity

(2019) Domyoung Kim et al.   BIOMACROMOLECULES

Non-antibiotic microbial solutions for bovine mastitis – live biotherapeutics, bacteriophage, and phage lysins

(2019) Angeliki Angelopoulou et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Fusion of Lysostaphin to an Albumin Binding Domain Prolongs Its Half-Life and Bactericidal Activity in the Systemic Circulation

(2019) Alexander V. Grishin et al.   MOLECULES

Therapeutic Potential of an Endolysin Derived from Kayvirus S25-3 for Staphylococcal Impetigo

(2019) Ichiro Imanishi et al.   Viruses-Basel

Comparative in vitro activity of bacteriophage endolysin HY-133 against Staphylococcus aureus attached to vascular graft surface

(2019) Evgeny A. Idelevich et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

On the design principles of peptide–drug conjugates for targeted drug delivery to the malignant tumor site

(2018) Eirinaios I Vrettos et al.   Beilstein Journal of Organic Chemistry

Synthetic biology of modular endolysins

(2018) Hans Gerstmans et al.   BIOTECHNOLOGY ADVANCES

Short communication: Recombinant bacteriophage endolysin PlyC is nontoxic and does not alter blood neutrophil oxidative response in lactating dairy cows

(2018) C.M. Scholte et al.   JOURNAL OF DAIRY SCIENCE

Restoration of sensitivity of a diverse set of drug-resistant Staphylococcus clinical strains by bactericidal protein P128

(2018) Sandhya Nair et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Phage-Derived Peptidoglycan Degrading Enzymes: Challenges and Future Prospects for In Vivo Therapy

(2018) Hugo Oliveira et al.   Viruses-Basel

Activity of the Chimeric Lysin ClyR against Common Gram-Positive Oral Microbes and Its Anticaries Efficacy in Rat Models

(2018) Jingjing Xu et al.   Viruses-Basel

Are Phage Lytic Proteins the Secret Weapon To Kill Staphylococcus aureus?

(2018) Diana Gutiérrez et al.   mBio

Lysostaphin Lysibody Leads to Effective Opsonization and Killing of Methicillin-Resistant Staphylococcus aureus in a Murine Model

(2018) Assaf Raz et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Staphylococcus aureusvirulence attenuation and immune clearance mediated by a phage lysin‐derived protein

(2018) Hang Yang et al.   EMBO JOURNAL

Synergistic Removal of Static and Dynamic Staphylococcus aureus Biofilms by Combined Treatment with a Bacteriophage Endolysin and a Polysaccharide Depolymerase

(2018) Nanna Olsen et al.   Viruses-Basel

Safety Studies of Pneumococcal Endolysins Cpl-1 and Pal

(2018) Marek Harhala et al.   Viruses-Basel

Improved Biodistribution and Extended Serum Half-Life of a Bacteriophage Endolysin by Albumin Binding Domain Fusion

(2018) Johan Seijsing et al.   Frontiers in Microbiology

Phage Lysins for Fighting Bacterial Respiratory Infections: A New Generation of Antimicrobials

(2018) Roberto Vázquez et al.   Frontiers in Immunology

Update on Antimicrobial Resistance in Clostridium difficile: Resistance Mechanisms and Antimicrobial Susceptibility Testing

(2017) Zhong Peng et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation

(2016) Amy Langdon et al.   Genome Medicine

Adapting Drug Approval Pathways for Bacteriophage-Based Therapeutics

(2016) Callum J. Cooper et al.   Frontiers in Microbiology

Depletion of T Cell Epitopes in Lysostaphin Mitigates Anti-Drug Antibody Response and Enhances Antibacterial Efficacy In Vivo

(2015) Hongliang Zhao et al.   CHEMISTRY & BIOLOGY

An overview of FDA-approved biologics medicines

(2015) Michael S. Kinch   DRUG DISCOVERY TODAY

Prevention and treatment ofStaphylococcus aureusbiofilms

(2015) Mohini Bhattacharya et al.   Expert Review of Anti-Infective Therapy

Structure-based redesign of lysostaphin yields potent antistaphylococcal enzymes that evade immune cell surveillance

(2015) Kristina Blazanovic et al.   Molecular Therapy-Methods & Clinical Development

Management of Skin Abscesses in the Era of Methicillin-Resistant Staphylococcus aureus

(2014) Adam J. Singer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Peptides for cell-selective drug delivery

(2012) Nina Svensen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Intracellular staphylococcus aureus: Live-in and let die

(2012) Martin Fraunholz et al.   Frontiers in Cellular and Infection Microbiology