The Preclinical and Clinical Progress of Bacteriophages and Their Lytic Enzymes: The Parts are Easier than the Whole

Synthetic biology of modular endolysins

(2018) Hans Gerstmans et al.   BIOTECHNOLOGY ADVANCES

A functional type II-A CRISPR–Cas system from Listeria enables efficient genome editing of large non-integrating bacteriophage

(2018) Mario Hupfeld et al.   NUCLEIC ACIDS RESEARCH

Comparative genome analysis of novel Podoviruses lytic for hypermucoviscous Klebsiella pneumoniae of K1, K2, and K57 capsular types

(2018) Ekaterina V. Solovieva et al.   VIRUS RESEARCH

The Magistral Phage

(2018) Jean-Paul Pirnay et al.   Viruses-Basel

Phage Therapy: What Have We Learned?

(2018) Andrzej Górski et al.   Viruses-Basel

Development of Phage Lysins as Novel Therapeutics: A Historical Perspective

(2018) Vincent Fischetti   Viruses-Basel

Efficacy of chimeric ectolysin P128 in drug-resistant Staphylococcus aureus bacteraemia in mice

(2018) Shankaramurthy Channabasappa et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

OUP accepted manuscript

(2018)   JOURNAL OF THE HISTORY OF MEDICINE AND ALLIED SCIENCES

Efficacy and tolerability of a cocktail of bacteriophages to treat burn wounds infected by Pseudomonas aeruginosa (PhagoBurn): a randomised, controlled, double-blind phase 1/2 trial

(2018) Patrick Jault et al.   LANCET INFECTIOUS DISEASES

A chemical defence against phage infection

(2018) Sarah Kronheim et al.   NATURE

Bacteriophage Therapy: Clinical Trials and Regulatory Hurdles

(2018) Lucy L. Furfaro et al.   Frontiers in Cellular and Infection Microbiology

Phage-Borne Depolymerases Decrease Klebsiella pneumoniae Resistance to Innate Defense Mechanisms

(2018) Grazyna Majkowska-Skrobek et al.   Frontiers in Microbiology

Explanation of the Nagoya Protocol on Access and Benefit Sharing and its implication for microbiology

(2017) David Smith et al.   MICROBIOLOGY-SGM

Pseudomonas predators: understanding and exploiting phage–host interactions

(2017) Jeroen De Smet et al.   NATURE REVIEWS MICROBIOLOGY

Targeted anti-staphylococcal therapy with endolysins in atopic dermatitis and the effect on steroid use, disease severity and the microbiome: study protocol for a randomized controlled trial (MAAS trial)

(2017) Joan Totté et al.   Trials

φBO1E, a newly discovered lytic bacteriophage targeting carbapenemase-producing Klebsiella pneumoniae of the pandemic Clonal Group 258 clade II lineage

(2017) Marco Maria D’Andrea et al.   Scientific Reports

Bacteriophages for treating urinary tract infections in patients undergoing transurethral resection of the prostate: a randomized, placebo-controlled, double-blind clinical trial

(2017) Lorenz Leitner et al.   BMC Urology

Therapeutic Application of Phage Capsule Depolymerases against K1, K5, and K30 Capsulated E. coli in Mice

(2017) Han Lin et al.   Frontiers in Microbiology

Pharmacokinetics of the phage endolysin-based candidate drug SAL200 in monkeys and its appropriate intravenous dosing period

(2016) Soo Youn Jun et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Alternatives to antibiotics—a pipeline portfolio review

(2016) Lloyd Czaplewski et al.   LANCET INFECTIOUS DISEASES

Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome

(2016) An Van den Bossche et al.   eLife

Oral Phage Therapy of Acute Bacterial Diarrhea With Two Coliphage Preparations: A Randomized Trial in Children From Bangladesh

(2016) Shafiqul Alam Sarker et al.   EBioMedicine

‘Artilysation’ of endolysin λSa2lys strongly improves its enzymatic and antibacterial activity against streptococci

(2016) Lorena Rodríguez-Rubio et al.   Scientific Reports

Effects of treatment with antimicrobial agents on the human colonic microflora

(2016) Fatemeh Rafii   Therapeutics and Clinical Risk Management

Complete genome sequence of novel T7-like virus vB_KpnP_KpV289 with lytic activity against Klebsiella pneumoniae

(2015) Nikolay V. Volozhantsev et al.   ARCHIVES OF VIROLOGY

Breaking barriers: expansion of the use of endolysins as novel antibacterials against Gram-negative bacteria

(2015) Yves Briers et al.   Future Microbiology

Pre-adapting parasitic phages to a pathogen leads to increased pathogen clearance and lowered resistance evolution withPseudomonas aeruginosacystic fibrosis bacterial isolates

(2015) V-P. Friman et al.   JOURNAL OF EVOLUTIONARY BIOLOGY

Antibacterial phage ORFans of Pseudomonas aeruginosa phage LUZ24 reveal a novel MvaT inhibiting protein

(2015) Jeroen Wagemans et al.   Frontiers in Microbiology

Art-175 Is a Highly Efficient Antibacterial against Multidrug-Resistant Strains and Persisters of Pseudomonas aeruginosa

(2014) Yves Briers et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Biofilm Formation by T7 Bacteriophages Producing Quorum-Quenching Enzymes

(2014) Ruoting Pei et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Depolymerase improves gentamicin efficacy during Klebsiella pneumoniae induced murine infection

(2014) Shruti Bansal et al.   BMC INFECTIOUS DISEASES

Functional elucidation of antibacterial phage ORFans targetingPseudomonas aeruginosa

(2014) Jeroen Wagemans et al.   CELLULAR MICROBIOLOGY

Isolation of a Bacteriophage and Its Depolymerase Specific for K1 Capsule of Klebsiella pneumoniae: Implication in Typing and Treatment

(2014) Tzu-Lung Lin et al.   JOURNAL OF INFECTIOUS DISEASES

Systematic Identification of Hypothetical Bacteriophage Proteins Targeting Key Protein Complexes of Pseudomonas aeruginosa

(2014) An Van den Bossche et al.   JOURNAL OF PROTEOME RESEARCH

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

(2014) Robert J Citorik et al.   NATURE BIOTECHNOLOGY

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Engineered Endolysin-Based "Artilysins" To Combat Multidrug-Resistant Gram-Negative Pathogens

(2014) Y. Briers et al.   mBio

Bacteriophage therapy of venous leg ulcers in humans: results of a phase I safety trial

(2014) D.D. Rhoads et al.   Journal of Wound Care

Novel Bacteriophage Lysin with Broad Lytic Activity Protects against Mixed Infection by Streptococcus pyogenes and Methicillin-Resistant Staphylococcus aureus

(2013) Daniel B. Gilmer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phage lysis: do we have the hole story yet?

(2013) Ry Young   CURRENT OPINION IN MICROBIOLOGY

World Medical Association Declaration of Helsinki

(2013)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Bacteriophage endolysins as novel antimicrobials

(2012) Mathias Schmelcher et al.   Future Microbiology

Introducing yesterday’s phage therapy in today’s medicine

(2012) Jean-Paul Pirnay et al.   Future Virology

A T3 and T7 Recombinant Phage Acquires Efficient Adsorption and a Broader Host Range

(2012) Tiao-Yin Lin et al.   PLoS One

Combinatorial targeting and discovery of ligand-receptors in organelles of mammalian cells

(2012) Roberto Rangel et al.   Nature Communications

Purification of phage display-modified bacteriophage T4 by affinity chromatography

(2011) Anna Oślizło et al.   BMC BIOTECHNOLOGY

Rapid Multiplex Detection and Differentiation of Listeria Cells by Use of Fluorescent Phage Endolysin Cell Wall Binding Domains

(2010) M. Schmelcher et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Phage Therapy Pharmacology

(2010) Stephen Abedon et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Phage Therapy in Clinical Practice: Treatment of Human Infections

(2010) Elizabeth Kutter et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bacteriophage endolysins: A novel anti-infective to control Gram-positive pathogens

(2010) Vincent A. Fischetti   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Systemic combinatorial peptide selection yields a non-canonical iron-mimicry mechanism for targeting tumors in a mouse model of human glioblastoma

(2010) Fernanda I. Staquicini et al.   JOURNAL OF CLINICAL INVESTIGATION

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistantPseudomonas aeruginosa; a preliminary report of efficacy

(2009) A. Wright et al.   CLINICAL OTOLARYNGOLOGY

Site-specific recombination of T2 phage using IP008 long tail fiber genes provides a targeted method for expanding host range while retaining lytic activity

(2009) Faezeh Mahichi et al.   FEMS MICROBIOLOGY LETTERS

BRED: A Simple and Powerful Tool for Constructing Mutant and Recombinant Bacteriophage Genomes

(2008) Laura J. Marinelli et al.   PLoS One