Optimization of BCG Therapy Targeting Neutrophil Extracellular Traps, Autophagy, and miRNAs in Bladder Cancer: Implications for Personalized Medicine

The vitals of NETs

(2020) Chuyi Tan et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Untangling “NETosis” from NETs

(2019) Shida Yousefi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

ATG7 Promotes Bladder Cancer Invasion via Autophagy-Mediated Increased ARHGDIB mRNA Stability

(2019) Junlan Zhu et al.   Advanced Science

Benzyl isothiocyanate suppresses IGF1R, FGFR3 and mTOR expression by upregulation of miR-99a-5p in human bladder cancer cells

(2019) Ji-Fan Lin et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

BCG-induced formation of neutrophil extracellular traps play an important role in bladder cancer treatment

(2019) Kangkang Liu et al.   CLINICAL IMMUNOLOGY

Neutrophils and neutrophil extracellular traps enhance venous thrombosis in mice bearing human pancreatic tumors

(2019) Yohei Hisada et al.   HAEMATOLOGICA

Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role?

(2019) Manuela Gonzalez-Aparicio et al.   Journal of Immunology Research

Transcriptomic insights into temporal expression pattern of autophagy genes during monocytic and granulocytic differentiation

(2018) Yan Huang et al.   Autophagy

miR-125b is downregulated in systemic lupus erythematosus patients and inhibits autophagy by targeting UVRAG

(2018) Wenting Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

MicroRNA-30a suppresses autophagy-mediated anoikis resistance and metastasis in hepatocellular carcinoma

(2018) Xiu-Tao Fu et al.   CANCER LETTERS

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

(2018) Eva Kaufmann et al.   CELL

Chemokines and cancer: new immune checkpoints for cancer therapy

(2018) Nathan Karin   CURRENT OPINION IN IMMUNOLOGY

Decreased neutrophil–associated miRNA and increased B-cell associated miRNA expression during tuberculosis

(2018) I.C. van Rensburg et al.   GENE

Mitochondrial Quality Control Mediated by PINK1 and PRKN: Links to Iron Metabolism and Tumor Immunity

(2018) Rui Kang et al.   Autophagy

MiR-125a-5p suppresses bladder cancer progression through targeting FUT4

(2018) Yuelong Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Cross-talk between lung cancer and bones results in neutrophils that promote tumor progression

(2018) Patrick O. Azevedo et al.   CANCER AND METASTASIS REVIEWS

Formyl-Peptide Receptors in Infection, Inflammation, and Cancer

(2018) Elisabeth Weiß et al.   TRENDS IN IMMUNOLOGY

Circulating miRNA panels for specific and early detection in bladder cancer

(2018) Wataru Usuba et al.   CANCER SCIENCE

Aging-related Atg5 defect impairs neutrophil extracellular traps formation

(2017) Fengying Xu et al.   IMMUNOLOGY

Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation

(2017) Nina Germic et al.   IMMUNOLOGY

Identification and bioinformatics analysis of miRNAs associated with human muscle invasive bladder cancer

(2017) Liang Chen et al.   Molecular Medicine Reports

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

Lysosome‑associated membrane protein 2 (LAMP‑2) expression induced by miR‑194‑5p downregulation contributes to sunitinib resistance in human renal cell carcinoma cells

(2017) Tetsuya Yumioka et al.   Oncology Letters

Retrograde signaling from autophagy modulates stress responses

(2017) Hans-Uwe Simon et al.   Science Signaling

miR-26b inhibits autophagy by targeting ULK2 in prostate cancer cells

(2016) Daguia Zambe John Clotaire et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neutrophil Extracellular Traps Promote the Development and Progression of Liver Metastases after Surgical Stress

(2016) Samer Tohme et al.   CANCER RESEARCH

Deconvoluting the complexity of microRNAs in autophagy to improve potential cancer therapy

(2016) Dahong Yao et al.   CELL PROLIFERATION

The CXCL8-CXCR1/2 pathways in cancer

(2016) Qian Liu et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Tumor-Associated Neutrophils Recruit Macrophages and T-Regulatory Cells to Promote Progression of Hepatocellular Carcinoma and Resistance to Sorafenib

(2016) Shao-Lai Zhou et al.   GASTROENTEROLOGY

MiR-20a and miR-20b negatively regulate autophagy by targeting RB1CC1/FIP200 in breast cancer cells

(2016) Shufeng Li et al.   LIFE SCIENCES

Neutrophil extracellular traps: protagonists of cancer progression?

(2016) L Erpenbeck et al.   ONCOGENE

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps

(2016) J. Park et al.   Science Translational Medicine

Neutrophils in the Tumor Microenvironment

(2016) Davalyn R. Powell et al.   TRENDS IN IMMUNOLOGY

MiR-200c promotes bladder cancer cell migration and invasion by directly targeting RECK

(2016) Pengchao Li et al.   OncoTargets and Therapy

Neutrophils Discriminate between Lipopolysaccharides of Different Bacterial Sources and Selectively Release Neutrophil Extracellular Traps

(2016) Elmar Pieterse et al.   Frontiers in Immunology

Downregulation of ATG14 by EGR1-MIR152 sensitizes ovarian cancer cells to cisplatin-induced apoptosis by inhibiting cyto-protective autophagy

(2015) Jun He et al.   Autophagy

MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin

(2015) Nunu Huang et al.   CANCER BIOLOGY & THERAPY

The receptor for advanced glycation end products (RAGE) enhances autophagy and neutrophil extracellular traps in pancreatic cancer

(2015) B A Boone et al.   CANCER GENE THERAPY

Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways

(2015) Amrita Chatterjee et al.   CANCER LETTERS

Cisplatin-Based First-Line Therapy for Advanced Urothelial Carcinoma After Previous Perioperative Cisplatin-Based Therapy

(2015) Andrea Necchi et al.   Clinical Genitourinary Cancer

Screening biomarkers of bladder cancer using combined miRNA and mRNA microarray analysis

(2015) NING JIN et al.   Molecular Medicine Reports

Expression and clinical significance of microRNA-21, maspin and vascular endothelial growth factor-C in bladder cancer

(2015) HUI-HUI ZHANG et al.   Oncology Letters

miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG

(2015) Longtao Huangfu et al.   Oncotarget

MicroRNA-423-5p Promotes Autophagy in Cancer Cells and Is Increased in Serum From Hepatocarcinoma Patients Treated With Sorafenib

(2015) Paola Stiuso et al.   Molecular Therapy-Nucleic Acids

MicroRNA-25 regulates chemoresistance-associated autophagy in breast cancer cells, a process modulated by the natural autophagy inducer isoliquiritigenin

(2015) Zhiyu Wang et al.   Oncotarget

p62/SQSTM1 at the interface of aging, autophagy, and disease

(2014) Alessandro Bitto et al.   AGE

Regulation of autophagy by a beclin 1-targeted microRNA, miR-30a, in cancer cells

(2014) Hua Zhu et al.   Autophagy

Metabolic Control of Autophagy

(2014) Lorenzo Galluzzi et al.   CELL

Innate immune responses and neuroepithelial degeneration and regeneration in the mouse olfactory mucosa induced by intranasal administration of Poly(I:C)

(2014) Kaori Kanaya et al.   CELL AND TISSUE RESEARCH

The generation of neutrophils in the bone marrow is controlled by autophagy

(2014) S Rožman et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress and autophagy: the clash between damage and metabolic needs

(2014) G Filomeni et al.   CELL DEATH AND DIFFERENTIATION

Neutrophil extracellular traps in cancer progression

(2014) Jonathan Cools-Lartigue et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation

(2014) Valentina Cianfanelli et al.   NATURE CELL BIOLOGY

The mechanism of action of BCG therapy for bladder cancer—a current perspective

(2014) Gil Redelman-Sidi et al.   Nature Reviews Urology

miR-17-5p Downregulation Contributes to Paclitaxel Resistance of Lung Cancer Cells through Altering Beclin1 Expression

(2014) Abhisek Chatterjee et al.   PLoS One

miR-34a Modulates Angiotensin II-Induced Myocardial Hypertrophy by Direct Inhibition of ATG9A Expression and Autophagic Activity

(2014) Jionghua Huang et al.   PLoS One

NETosis: A New Factor in Tumor Progression and Cancer-Associated Thrombosis

(2014) Melanie Demers et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer

(2014) Kathrin Buffen et al.   PLoS Pathogens

Human polymorphonuclear neutrophils specifically recognize and kill cancerous cells

(2014) Jun Yan et al.   OncoImmunology

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells

(2013) Kwang Woon Kim et al.   Autophagy

Autophagy promotes hepatocellular carcinoma cell invasion through activation of epithelial–mesenchymal transition

(2013) Jun Li et al.   CARCINOGENESIS

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis

(2013) J. Y. Guo et al.   GENES & DEVELOPMENT

miR-106b Fine Tunes ATG16L1 Expression and Autophagic Activity in Intestinal Epithelial HCT116 Cells

(2013) Zili Zhai et al.   INFLAMMATORY BOWEL DISEASES

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis

(2013) Jonathan Cools-Lartigue et al.   JOURNAL OF CLINICAL INVESTIGATION

The not-so-neutral role of microRNAs in neutrophil biology

(2013) Michael P. Gantier   JOURNAL OF LEUKOCYTE BIOLOGY

Identification of microRNAs in blood and urine as tumour markers for the detection of urinary bladder cancer

(2013) ANGELIKA TÖLLE et al.   ONCOLOGY REPORTS

Targeting autophagy as a potential therapeutic approach for melanoma therapy

(2013) He Liu et al.   SEMINARS IN CANCER BIOLOGY

PMN and anti-tumor immunity—The case of bladder cancer immunotherapy

(2013) Erik L. Brincks et al.   SEMINARS IN CANCER BIOLOGY

Molecular mechanisms regulating NETosis in infection and disease

(2013) Nora Branzk et al.   Seminars in Immunopathology

microR-142-3p down-regulates IRAK-1 in response to Mycobacterium bovis BCG infection in macrophages

(2013) Guangxian Xu et al.   TUBERCULOSIS

Defective Stromal Remodeling and Neutrophil Extracellular Traps in Lymphoid Tissues Favor the Transition from Autoimmunity to Lymphoma

(2013) S. Sangaletti et al.   Cancer Discovery

A proposed role for neutrophil extracellular traps in cancer immunoediting

(2013) Sivan Berger-Achituv et al.   Frontiers in Immunology

microRNA30Apromotes autophagy in response to cancer therapy

(2012) Yan Yu et al.   Autophagy

Cisplatin-induced downregulation of miR-199a-5p increases drug resistance by activating autophagy in HCC cell

(2012) Ning Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Breast Cancer Cell Uptake of the Inflammatory Mediator Neutrophil Elastase Triggers an Anticancer Adaptive Immune Response

(2012) E. A. Mittendorf et al.   CANCER RESEARCH

Hypoxia-Induced Autophagy Promotes Tumor Cell Survival and Adaptation to Antiangiogenic Treatment in Glioblastoma

(2012) Y.-L. Hu et al.   CANCER RESEARCH

miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells

(2012) V. Kovaleva et al.   CANCER RESEARCH

Neutrophils Promote Liver Metastasis via Mac-1–Mediated Interactions with Circulating Tumor Cells

(2012) Jonathan D. Spicer et al.   CANCER RESEARCH

MiR-20a and miR-106b negatively regulate autophagy induced by leucine deprivation via suppression of ULK1 expression in C2C12 myoblasts

(2012) Hao Wu et al.   CELLULAR SIGNALLING

Autophagy in tumor suppression and cancer therapy

(2012) Che-Pei Kung et al.   CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION

Methylation of a Panel of MicroRNA Genes Is a Novel Biomarker for Detection of Bladder Cancer

(2012) Takashi Shimizu et al.   EUROPEAN UROLOGY

MicroRNA-modulated autophagic signaling networks in cancer

(2012) Lei-lei Fu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Randomized Phase III Study Comparing Paclitaxel/Cisplatin/ Gemcitabine and Gemcitabine/Cisplatin in Patients With Locally Advanced or Metastatic Urothelial Cancer Without Prior Systemic Therapy: EORTC Intergroup Study 30987

(2012) Joaquim Bellmunt et al.   JOURNAL OF CLINICAL ONCOLOGY

T Lymphocyte Priming by Neutrophil Extracellular Traps Links Innate and Adaptive Immune Responses

(2012) K. Tillack et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-155 Is Required for Mycobacterium bovis BCG-Mediated Apoptosis of Macrophages

(2012) D. S. Ghorpade et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-18a upregulates autophagy and ataxia telangiectasia mutated gene expression in HCT116 colon cancer cells

(2012) ABU BAKER QASED et al.   Molecular Medicine Reports

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

(2012) Mona Saffarzadeh et al.   PLoS One

Bacille Calmette-Guerin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

(2012) J. Kleinnijenhuis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

(2012) M. Demers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor Entrained Neutrophils Inhibit Seeding in the Premetastatic Lung

(2011) Zvi Granot et al.   CANCER CELL

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality

(2011) Q Remijsen et al.   CELL DEATH AND DIFFERENTIATION

Microautophagy: lesser-known self-eating

(2011) Wen-wen Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

On the dual roles and polarized phenotypes of neutrophils in tumor development and progression

(2011) H. Piccard et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The dual role of autophagy in cancer

(2011) Eeva-Liisa Eskelinen   CURRENT OPINION IN PHARMACOLOGY

microRNA-101 is a potent inhibitor of autophagy

(2011) Lisa B Frankel et al.   EMBO JOURNAL

EAU Guidelines on Non–Muscle-Invasive Urothelial Carcinoma of the Bladder, the 2011 Update

(2011) Marko Babjuk et al.   EUROPEAN UROLOGY

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Autophagy-deficient mice develop multiple liver tumors

(2011) A. Takamura et al.   GENES & DEVELOPMENT

Oncolytic Activities of Host Defense Peptides

(2011) Sammy Al-Benna et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Overcoming anoikis - pathways to anchorage-independent growth in cancer

(2011) M. C. Guadamillas et al.   JOURNAL OF CELL SCIENCE

The Role of Autophagy in Cancer: Therapeutic Implications

(2011) Z. J. Yang et al.   MOLECULAR CANCER THERAPEUTICS

MicroRNA Expression Signatures of Bladder Cancer Revealed by Deep Sequencing

(2011) Yonghua Han et al.   PLoS One

Regulation of Autophagy by Kinases

(2011) Savitha Sridharan et al.   Cancers

Interferon-γ Production by Neutrophils during Bacterial Pneumonia in Mice

(2010) Mitsuhiro Yamada et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

The paradox of tumor-associated neutrophils: Fueling tumor growth with cytotoxic substances

(2010) A. McGarry Houghton   CELL CYCLE

MiRNAs as biomarkers and therapeutic targets in cancer☆

(2010) Helen M Heneghan et al.   CURRENT OPINION IN PHARMACOLOGY

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Selective degradation of p62 by autophagy

(2010) Yoshinobu Ichimura et al.   Seminars in Immunopathology

The paradox of autophagy and its implication in cancer etiology and therapy

(2009) Avital Eisenberg-Lerner et al.   APOPTOSIS

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

Autophagy and metastasis: another double-edged sword

(2009) Candia M Kenific et al.   CURRENT OPINION IN CELL BIOLOGY

Mammalian autophagy: core molecular machinery and signaling regulation

(2009) Zhifen Yang et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of novel microRNA targets based on microRNA signatures in bladder cancer

(2009) Takahiro Ichimi et al.   INTERNATIONAL JOURNAL OF CANCER

Systemic inflammation increases cancer cell adhesion to hepatic sinusoids by neutrophil mediated mechanisms

(2009) Braedon McDonald et al.   INTERNATIONAL JOURNAL OF CANCER

Polymorphonuclear neutrophils and cancer: Intense and sustained neutrophilia as a treatment against solid tumors

(2009) Juan Carlos Souto et al.   MEDICINAL RESEARCH REVIEWS

Autophagy enhances the efficacy of BCG vaccine by increasing peptide presentation in mouse dendritic cells

(2009) Chinnaswamy Jagannath et al.   NATURE MEDICINE

Effects of the Tumor-Leukocyte Microenvironment on Melanoma–Neutrophil Adhesion to the Endothelium in a Shear Flow

(2008) Shile Liang et al.   Cellular and Molecular Bioengineering

Temsirolimus downregulates p21 without altering cyclin D1 expression and induces autophagy and synergizes with vorinostat in mantle cell lymphoma

(2008) Victor Y. Yazbeck et al.   EXPERIMENTAL HEMATOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Role of neutrophils in BCG immunotherapy for bladder cancer

(2008) Mark P. Simons et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS